Tryptophan-specific modification and diversification of peptides and proteins
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
provides
an
account
of
the
tryptophan-specific
conjugation
peptides
and
proteins
its
extensive
application
in
imaging
living
cells,
radiolabelling
proteins,
protein
engineering,
etc
.
Язык: Английский
Unlocking Diversity: From Simple to Cutting-Edge Synthetic Methodologies of Bis(indolyl)methanes
Topics in Current Chemistry,
Год журнала:
2024,
Номер
382(1)
Опубликована: Фев. 25, 2024
Язык: Английский
Metal-Free Late-Stage Alkylation of Tryptophan and Tryptophan-Containing Peptides with 1,3-Dithiane Derivatives
Mingming Mao,
Jia Li,
Kang Dong
и другие.
Organic Letters,
Год журнала:
2023,
Номер
25(31), С. 5784 - 5789
Опубликована: Июль 28, 2023
Late-stage
diversification
of
structurally
complex
peptides
has
enormous
potential
for
drug
discovery
and
molecular
imaging.
We
report
a
simple,
metal-free,
late-stage
reductive
C2
alkylation
tryptophan
tryptophan-containing
using
readily
available
1,3-dithianes.
This
protocol
wide
substrate
scope
an
excellent
tolerance
reactive
functional
groups.
Язык: Английский
A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation
ACS Central Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
A
multidisciplinary
platform
is
presented
to
address
aryl
hydrocarbon
receptor
(AhR)
modulation.
rewired
Yonemitsu
multicomponent
reaction
with
indole
2-carboxaldehydes
and
nucleophilic
species
was
designed
access
a
family
of
6-substituted
indolocarbazoles.
The
conformational
behavior
these
compounds
examined
rationalize
their
axial
chirality.
In
silico
docking
molecular
simulations
highlighted
key
features
implicated
in
binding
AhR.
Furthermore,
the
synthesis
linkable
derivatives
allowed
direct
development
conjugated
entities.
Reporter
gene
target
expression
analyses
identified
novel
structures
as
potent
noncytotoxic
activating
AhR
ligands,
that
can
be
extended
bifunctional
molecules.
anti-inflammatory
properties
agonists
were
assessed
interleukin-13
treated
keratinocytes.
Altogether,
synergistic
research
synthetic
computational
chemistry
integrated
biological
studies
opens
avenues
toward
understanding
roles
targeted
therapeutics.
Язык: Английский
Divergent Synthesis of 3-Pyrrolidin-2-yl-1H-indoles, Symmetric and Unsymmetric Bis(Indolyl)Methanes (BIMs) through Photocatalyzed Decarboxylative Coupling/Friedel–Crafts Alkylation Reaction
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(7), С. 4052 - 4065
Опубликована: Март 7, 2023
This
paper
reports
the
acid-controlled
divergent
synthesis
of
3-pyrrolidin-2-yl-1H-indoles
and
symmetric
unsymmetrical
bis(indolyl)methanes
(BIMs)
through
photocatalyzed
decarboxylative
coupling
Friedel-Crafts
alkylation
reactions,
respectively.
The
protocol
involves
C-H
functionalization,
switching
formation
two
products,
room-temperature
conditions,
low
photocatalyst
loadings,
without
strong
oxidant,
moderate
to
excellent
yields.
method
has
been
applied
for
natural
product
vibrindole
A
1,1-bis(1H-indol-3-yl)-2-phenylethane.
Язык: Английский