Site-selective cleavage of peptides and proteins targeting aromatic amino acid residues
RSC Advances,
Год журнала:
2025,
Номер
15(12), С. 9159 - 9179
Опубликована: Янв. 1, 2025
This
review
provides
an
account
of
the
site-selective
cleavage
peptides
and
proteins
at
aromatic
amino
acid
residues,
developed
over
last
seven
decades
(1958–2024).
Язык: Английский
Residue-Specific Protein-Glycan Conjugation Strategies for the Development of Pharmaceutically Promising Glycoconjugate Vaccines: A Recent Update
Carbohydrate Research,
Год журнала:
2025,
Номер
unknown, С. 109476 - 109476
Опубликована: Апрель 1, 2025
Язык: Английский
Late-Stage N-Arylation of Tryptophan-Containing Peptides and Drug Molecules via Arylthianthrenium Salts
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
We
report
herein
a
mild
and
efficient
method
for
the
late-stage
N-arylation
of
tryptophan
tryptophan-containing
peptides
using
readily
accessible
arylthianthrenium
salts
through
dual
photoredox/copper
catalysis.
Applying
this
protocol,
library
noncanonical
amino
acids
N-arylated
was
facilely
prepared.
Moreover,
protocol
enables
peptide
ligation
conjugation,
offering
convenient
access
to
ligated
peptide/drug
conjugates.
Remarkably,
strategy
can
also
be
applied
modification
complex
drug
molecules.
Язык: Английский