Total Synthesis of (±)-Rubriflordilactone A

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(11), С. 7198 - 7203

Опубликована: Март 8, 2024

A new and efficient synthesis of rubriflordilactone has been realized. The key transformations include the following: (1) an intramolecular Prins cyclization to establish seven-membered ring containing two contiguous stereocenters; (2) a Mukaiyama hydration/oxa-Michael cascade construct B-ring; (3) unprecedented stereocontrol intermolecular o-QM type [4 + 2]-cycloaddition rapidly assemble core structure A.

Язык: Английский

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Brønsted Acid Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of 2-Vinylchromans

Synlett, Год журнала: 2024, Номер 35(18), С. 2148 - 2152

Опубликована: Апрель 8, 2024

Abstract Brønsted acid catalyzed intramolecular allylic substitution reaction of secondary and tertiary alcohols has been developed. A variety 2-vinylchromans were efficiently prepared in moderate to excellent yields. The given method features wide substrate scope, operational simplicity, mild, metal-free conditions. practicability the was demonstrated by a gram-scale further derivations product. Preliminarily studies on catalytic asymmetric also undertaken.

Язык: Английский

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Seven-membered rings

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 569 - 628

Опубликована: Янв. 1, 2023

Язык: Английский

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Six-membered ring systems: With O and/or S atoms

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 493 - 568

Опубликована: Янв. 1, 2023

Язык: Английский

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