Total Synthesis of (±)-Rubriflordilactone A

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(11), P. 7198 - 7203

Published: March 8, 2024

A new and efficient synthesis of rubriflordilactone has been realized. The key transformations include the following: (1) an intramolecular Prins cyclization to establish seven-membered ring containing two contiguous stereocenters; (2) a Mukaiyama hydration/oxa-Michael cascade construct B-ring; (3) unprecedented stereocontrol intermolecular o-QM type [4 + 2]-cycloaddition rapidly assemble core structure A.

Language: Английский

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Brønsted Acid Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of 2-Vinylchromans

Synlett, Journal Year: 2024, Volume and Issue: 35(18), P. 2148 - 2152

Published: April 8, 2024

Abstract Brønsted acid catalyzed intramolecular allylic substitution reaction of secondary and tertiary alcohols has been developed. A variety 2-vinylchromans were efficiently prepared in moderate to excellent yields. The given method features wide substrate scope, operational simplicity, mild, metal-free conditions. practicability the was demonstrated by a gram-scale further derivations product. Preliminarily studies on catalytic asymmetric also undertaken.

Language: Английский

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Seven-membered rings

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 569 - 628

Published: Jan. 1, 2023

Language: Английский

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Six-membered ring systems: With O and/or S atoms

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 493 - 568

Published: Jan. 1, 2023

Language: Английский

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