Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

Pharmacology & Therapeutics, Год журнала: 2023, Номер 254, С. 108579 - 108579

Опубликована: Дек. 30, 2023

Язык: Английский

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Efficient and Sustainable Electrosynthesis of N-Sulfonyl Iminophosphoranes by the Dehydrogenative P–N Coupling Reaction

JACS Au, Год журнала: 2024, Номер 4(6), С. 2188 - 2196

Опубликована: Апрель 18, 2024

Iminophosphoranes are commonly used reagents in organic synthesis and are, therefore, of great interest. An efficient sustainable iodide-mediated electrochemical N-sulfonyl iminophosphoranes from readily available phosphines sulfonamides is reported. This method features low amounts supporting electrolytes, inexpensive electrode materials, a simple galvanostatic setup, high conversion rates. The broad applicability could be demonstrated by synthesizing 20 examples yields up to 90%, having diverse functional groups including chiral moieties biologically relevant species. Furthermore, electrolysis was performed on g scale run repetitive mode recycling the electrolyte, which illustrates suitability for large-scale production. A reaction mechanism involving mediation iodide-based electrolyte proposed, completely agreeing with all results.

Язык: Английский

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One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline

Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 912 - 920

Опубликована: Апрель 23, 2024

A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via performance one-pot Ugi-azide Heck cyclization reactions. The integration multicomponent post-condensation reactions in maximizes pot-, atom-, step-economy (PASE).

Язык: Английский

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One-pot Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones via a Sequential Ugi-4CR and Nucleophilic Substitution Reaction

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134609 - 134609

Опубликована: Март 1, 2025

Язык: Английский

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New efficient synthesis of polysubstituted benzo[d]pyrido[1′,2':1,2]imidazo[4,5-f][1,3]diazepines and pyrido[2′,1':2,3]imidazo[1,5-c]quinazolin-7-ium salts via Groebke-Blackburn-Bienaymé/Staudinger/aza-Wittig/carbodiimide-mediated annulation sequence

Tetrahedron, Год журнала: 2024, Номер 152, С. 133834 - 133834

Опубликована: Янв. 9, 2024

Язык: Английский

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Synthesis of Luminescent Indolo[2,1-b]quinazolin-6(12H)-ones via a Sequential Ugi/Iodine-Promoted Cyclization/Staudinger/Aza-Wittig Reaction

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(23), С. 16424 - 16434

Опубликована: Ноя. 9, 2023

A new efficient synthesis of indolo[2,1-b]quinazolin-6(12H)-ones via a sequential Ugi/iodine-promoted cyclization/Staudinger/aza-Wittig reaction was developed. The acid catalyzed three-component reactions 2-azidobenzaldehydes, 2-[2-(trimethylsilyl)ethynyl]benzenamines (or o-aminoacetophenones), and isocyanides gave Ugi-3CR intermediates, which reacted subsequently with I2/DMSO triphenylphosphine to produce in good overall yields. obtained were all colored bright red or orange. Their luminescent property studied preliminarily some them showed high molar absorption coefficients, strong fluorescence emission intensity, absolute light quantum

Язык: Английский

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Triflic-acid promoted post-Ugi condensation for the assembly of 2,6-diarylmorpholin-3-ones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A two-step one-pot synthesis of 2,6-diarylmorpholin-3-ones involving Ugi reaction followed by a triflic acid-promoted intramolecular condensation accompanied loss the isocyanide-originated amide moiety is described.

Язык: Английский

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Diversification of 4-bromo-1H-indole-3-carbaldehyde-derived Ugi adducts: Access to the azepino[3,4,5-cd]indoles and spiroindolines

Tetrahedron Letters, Год журнала: 2023, Номер 130, С. 154769 - 154769

Опубликована: Сен. 26, 2023

Язык: Английский

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One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline

Опубликована: Янв. 18, 2024

A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via performance one-pot Ugi-azide Heck cyclization reactions. The integration multicomponent post-condensation reactions in maximizes pot-, atom-, step-economy (PASE).

Язык: Английский

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Facile Synthesis of Dihydroisobenzofuran Derivatives Via a One-Pot Sequential Passerini-Azide/Ag(I)-Catalyzed Cyclization Process

Опубликована: Янв. 1, 2024

A facile one-pot synthesis of dihydroisobenzofuran derivatives by Passerini-azide/Ag(I)-catalyzed cyclization sequence has been developed. The Passerini-azide reactions 2-(alkynyl)benzaldehydes, trimethylsilyl azide, and isocyanides gave tetrazole intermediates, which were transformed to the dihydroisobenzofurans in moderate good yields via Ag(I)-catalyzed 5-exo-dig reaction.

Язык: Английский

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