Six-membered ring systems: Diazines and benzo derivatives DOI

K. Alison Rinderspacher

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393

Published: Jan. 1, 2024

Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets DOI
Alia Mushtaq, Peng Wu, Muhammad Moazzam Naseer

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 254, P. 108579 - 108579

Published: Dec. 30, 2023

Language: Английский

Citations

19
Efficient and Sustainable Electrosynthesis of N-Sulfonyl Iminophosphoranes by the Dehydrogenative P–N Coupling Reaction DOI Creative Commons

Jessica C. Bieniek,

Darryl Nater,

Sara L. Eberwein

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(6), P. 2188 - 2196

Published: April 18, 2024

Iminophosphoranes are commonly used reagents in organic synthesis and are, therefore, of great interest. An efficient sustainable iodide-mediated electrochemical N-sulfonyl iminophosphoranes from readily available phosphines sulfonamides is reported. This method features low amounts supporting electrolytes, inexpensive electrode materials, a simple galvanostatic setup, high conversion rates. The broad applicability could be demonstrated by synthesizing 20 examples yields up to 90%, having diverse functional groups including chiral moieties biologically relevant species. Furthermore, electrolysis was performed on g scale run repetitive mode recycling the electrolyte, which illustrates suitability for large-scale production. A reaction mechanism involving mediation iodide-based electrolyte proposed, completely agreeing with all results.

Language: Английский

Citations

3
One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline DOI Creative Commons

Jiawei Niu,

Yu‐Hui Wang,

Shenghu Yan

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 912 - 920

Published: April 23, 2024

A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via performance one-pot Ugi-azide Heck cyclization reactions. The integration multicomponent post-condensation reactions in maximizes pot-, atom-, step-economy (PASE).

Language: Английский

Citations

3
One-pot Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones via a Sequential Ugi-4CR and Nucleophilic Substitution Reaction DOI

Hong‐Ling Pan,

Han‐Han Kong, Ming‐Wu Ding

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134609 - 134609

Published: March 1, 2025

Language: Английский

Citations

0
New efficient synthesis of polysubstituted benzo[d]pyrido[1′,2':1,2]imidazo[4,5-f][1,3]diazepines and pyrido[2′,1':2,3]imidazo[1,5-c]quinazolin-7-ium salts via Groebke-Blackburn-Bienaymé/Staudinger/aza-Wittig/carbodiimide-mediated annulation sequence DOI

Long Zhao,

Mao-Lin Yang,

Hao Chen

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 152, P. 133834 - 133834

Published: Jan. 9, 2024

Language: Английский

Citations

2
Synthesis of Luminescent Indolo[2,1-b]quinazolin-6(12H)-ones via a Sequential Ugi/Iodine-Promoted Cyclization/Staudinger/Aza-Wittig Reaction DOI

Mao-Lin Yang,

Long Zhao,

Hao Chen

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(23), P. 16424 - 16434

Published: Nov. 9, 2023

A new efficient synthesis of indolo[2,1-b]quinazolin-6(12H)-ones via a sequential Ugi/iodine-promoted cyclization/Staudinger/aza-Wittig reaction was developed. The acid catalyzed three-component reactions 2-azidobenzaldehydes, 2-[2-(trimethylsilyl)ethynyl]benzenamines (or o-aminoacetophenones), and isocyanides gave Ugi-3CR intermediates, which reacted subsequently with I2/DMSO triphenylphosphine to produce in good overall yields. obtained were all colored bright red or orange. Their luminescent property studied preliminarily some them showed high molar absorption coefficients, strong fluorescence emission intensity, absolute light quantum

Language: Английский

Citations

4
Triflic-acid promoted post-Ugi condensation for the assembly of 2,6-diarylmorpholin-3-ones DOI

Niyaz Amire,

Kamila M. Almagambetova,

Assel Turlykul

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A two-step one-pot synthesis of 2,6-diarylmorpholin-3-ones involving Ugi reaction followed by a triflic acid-promoted intramolecular condensation accompanied loss the isocyanide-originated amide moiety is described.

Language: Английский

Citations

1
Diversification of 4-bromo-1H-indole-3-carbaldehyde-derived Ugi adducts: Access to the azepino[3,4,5-cd]indoles and spiroindolines DOI

Manzoor Zaman,

Muhammad Hasan, Anatoly A. Peshkov

et al.

Tetrahedron Letters, Journal Year: 2023, Volume and Issue: 130, P. 154769 - 154769

Published: Sept. 26, 2023

Language: Английский

Citations

2
One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline DOI Creative Commons

Jiawei Niu,

Yu‐Hui Wang,

Shenghu Yan

et al.

Published: Jan. 18, 2024

A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via performance one-pot Ugi-azide Heck cyclization reactions. The integration multicomponent post-condensation reactions in maximizes pot-, atom-, step-economy (PASE).

Language: Английский

Citations

0
Facile Synthesis of Dihydroisobenzofuran Derivatives Via a One-Pot Sequential Passerini-Azide/Ag(I)-Catalyzed Cyclization Process DOI

Yan Luo,

Haifeng Yu,

Yang Li-na

et al.

Published: Jan. 1, 2024

A facile one-pot synthesis of dihydroisobenzofuran derivatives by Passerini-azide/Ag(I)-catalyzed cyclization sequence has been developed. The Passerini-azide reactions 2-(alkynyl)benzaldehydes, trimethylsilyl azide, and isocyanides gave tetrazole intermediates, which were transformed to the dihydroisobenzofurans in moderate good yields via Ag(I)-catalyzed 5-exo-dig reaction.

Language: Английский

Citations

0