Recent Advances in Photo-promoted Generalized C3-H Alkylation of Quinoxalin-2(1H)-ones

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Recent advances in the photo-promoted C3–H alkylation reaction of quinoxalin-2(1 H )-ones with different agents.

Язык: Английский

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Metal and catalyst-free strategy to access 1,3-thio-heteroaryl BCP derivatives

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(40), С. 8136 - 8140

Опубликована: Янв. 1, 2023

The widespread presence of bicyclo[1.1.1]pentane (BCP) and sulfur motifs in pharmaceutical compounds underscores the significance synthesizing suitably functionalized BCP thioethers. In response, we have developed a metal-free photocatalyst-free strategy that harnesses visible light-induced radical cascades. This approach culminates synthesis essential thio-BCP derivatives, which serve as crucial precursors for formation corresponding sulfoxides, sulfones, sulfoximines. Importantly, this methodology exhibits potential large-scale applications, displaying commendable tolerance towards various functional groups while operating under mild reaction conditions.

Язык: Английский

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Lewis Acid-Mediated Isothiocyanation and Chlorination of Quinoxalin-2(1H)-ones under Visible Light Conditions

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10760 - 10772

Опубликована: Июль 11, 2024

Lewis acid-mediated selective C3-isothiocyanation of quinoxalin-2(1

Язык: Английский

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Synthetic Routes to Access Dicarbonylated Aryls and Heteroaryls

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The regioselective 1,2-dicarbonylation of aryls and heteroaryls offers access to functionalized dicarbonylated heteroaryls, which opens pharmaceuticals bioactive molecules with diverse synthetic utility.

Язык: Английский

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Metal-Free Addition of Alkyl Bromides to Access 3,3-Disubstituted Quinoxalinones Enabled by Visible-Light Photoredox Catalysis

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(16), С. 11762 - 11766

Опубликована: Авг. 9, 2023

A metal-free addition of unactivated alkyl bromides to quinoxalin-2(1H)-ones is described. This method enables the construction valuable 3,3-disubstituted dihydroquinoxalin-2(1H)-ones bearing quaternary carbon centers under mild, visible-light photoredox catalysis. High functional group tolerance observed in both quinoxalinone and bromide partners. The ability scale up this was demonstrated photo-flow conditions enable gram-scale synthesis.

Язык: Английский

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Ionic liquid-catalysed regioselective oxygenation of quinoxalin-2(1H)-ones under visible-light conditions

New Journal of Chemistry, Год журнала: 2023, Номер 47(47), С. 21596 - 21599

Опубликована: Янв. 1, 2023

Ionic liquid-catalysed oxygenation of quinoxalin-2(1 H )-one utilizing aerobic oxygen as a green oxidant under visible light conditions at room temperature is described.

Язык: Английский

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Photoinduced Alkenylation of Alkenyl Sulfones with EDA Complexes between NHPI Esters and HE

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(7)

Опубликована: Апрель 17, 2024

Abstract A novel alkenylation reaction between N ‐hydroxyphthalimide (NHPI) esters and alkenyl sulfones is reported. It undergoes the formation of electron donor‐acceptor (EDA) complex a series alkenes are obtained in good to excellent yields. has advantages simple operation, mild conditions, metal‐free.

Язык: Английский

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Catalyst-free decarboxylative cross-coupling of N-hydroxyphthalimide esters with tert-butyl 2-(trifluoromethyl)acrylate and its application

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(11), С. 2279 - 2283

Опубликована: Янв. 1, 2024

Here, we demonstrate a practical method toward the facile synthesis of CF

Язык: Английский

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Metal- and photocatalyst-free approach to visible-light-induced acylation of quinoxalinones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(29), С. 5924 - 5929

Опубликована: Янв. 1, 2024

A transition-metal- and photocatalyst-free photochemical acylation strategy driven by the photoexcitation of an electron donor–acceptor (EDA) complex has been developed.

Язык: Английский

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Photoredox Cross Dehydrogenative C(sp²)-C(sp³) Coupling of Heteroarenes with Secondary Amines through 1,5-HAT

Chemical Communications, Год журнала: 2024, Номер 60(72), С. 9757 - 9760

Опубликована: Янв. 1, 2024

The functionalization of α-C(sp

Язык: Английский

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