Current Organic Synthesis,
Год журнала:
2023,
Номер
21(8), С. 965 - 975
Опубликована: Авг. 29, 2023
Abstract:
Visible
light-induced
reactions
are
a
rapidly
developing
and
powerful
technique
to
pro-mote
organic
transformations.
They
provide
green
sustainable
chemistry
have
recently
re-ceived
increasing
attention
from
chemists
due
their
wide
application
in
synthesis.
Light
energy
is
eco-friendly,
cheap,
green,
inexhaustible
with
potential
industrial
pharmaceutical
applications.
In
this
review,
the
most
recent
advances
visible
(2021-till
date)
been
highlighted.
We
present
a
Pd-IPent-catalyzed
ring-opening
defluorinative
annulation
reaction
of
gem-difluorocyclopropanes
with
enamides,
which
provides
convenient
and
efficient
strategy
for
the
synthesis
multisubstituted
N-H
pyrrole
derivatives.
This
transformation
selectively
cleaves
C1-C3
bond,
two
C-F
bonds,
C-N
bond
in
one-pot
procedure.
Additionally,
this
protocol
allows
modification
several
bioactive
molecules.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(17), С. 12744 - 12754
Опубликована: Авг. 23, 2023
A
switchable
synthesis
of
alcohols
and
ketones
bearing
a
CF2-OR
scaffold
using
visible-light
promotion
is
described.
The
method
PDI
catalysis
characterized
by
its
ease
operation,
broad
substrate
scopes,
the
ability
to
switch
between
desired
products
without
need
for
transition
metal
catalysts.
addition
or
absence
base
plays
key
role
in
controlling
major
products.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 30, 2024
The
selective
incorporation
of
a
deuterium
atom
into
small
molecules
with
high
selectivity
is
highly
valuable
for
medical
and
chemical
research.
Unfortunately,
this
remains
challenging
due
to
the
complete
deuteration
caused
by
commonly
used
hydrogen
isotope
exchange
strategies.
We
report
development
photocatalytic
monodeuteration
protocol
utilizing
C-C
bond
as
unconventional
functional
handle.
synergistic
combination
radical-mediated
scission
transfer
processes
enables
effective
constructions
benzylic
CDH
moieties
monodeuteration.
combinational
use
bisphosphonium
photocatalyst,
thiol
catalyst,
CH
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(30), С. 14162 - 14170
Опубликована: Июль 17, 2024
Aromaticity
is
a
fundamental
concept
in
organic
chemistry.
Hyperconjugative
aromaticity,
also
known
as
hyperconjugation-induced
has
evolved
from
its
origin
main
group
substituents
to
transition
metal
analogues,
establishing
itself
an
important
category
of
aromaticity.
Additionally,
aromatic
compounds
comprising
two
Difluoromethylene
and
pyridine
cores
are
very
important
structural
units
in
medicinal
chemistry.
Herein,
we
report
the
development
of
photoredox-catalyzed
ring-opening
1,3-alkoxypyridylation
gem-difluorinated
cyclopropanes
using
4-cyanopyrines
alcohols,
employing
cyclopropane
radical
cations
as
key
intermediate.
The
reaction
exhibits
high
regioselectivity
under
mild
conditions
can
also
be
practiced
on
gram-scale
synthesis,
telescoped
reaction,
late-stage
functionalization
biological
molecules.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(23)
Опубликована: Фев. 27, 2024
Abstract
A
novel
enantioselective
Tsuji–Trost‐type
cross
coupling
reaction
between
gem
‐difluorinated
cyclopropanes
and
N
‐unprotected
amino
acid
esters
enabled
by
synergistic
Pd/Ni/chiral
aldehyde
catalysis
is
presented
herein.
This
transformation
streamlined
the
diversity‐oriented
synthesis
(DOS)
of
optically
active
α‐quaternary
α‐amino
bearing
a
linear
2‐fluoroallylic
motif,
which
served
as
an
appealing
platform
for
construction
other
valuable
enantioenriched
compounds.
The
key
intermediates
were
confirmed
HRMS
detection,
while
DFT
calculations
revealed
that
excellent
enantioselectivity
was
attributed
to
stabilizing
non‐covalent
interactions
Pd(II)‐π‐fluoroallyl
species
Ni(II)‐Schiff
base
complex.
Current Organic Synthesis,
Год журнала:
2023,
Номер
21(8), С. 965 - 975
Опубликована: Авг. 29, 2023
Abstract:
Visible
light-induced
reactions
are
a
rapidly
developing
and
powerful
technique
to
pro-mote
organic
transformations.
They
provide
green
sustainable
chemistry
have
recently
re-ceived
increasing
attention
from
chemists
due
their
wide
application
in
synthesis.
Light
energy
is
eco-friendly,
cheap,
green,
inexhaustible
with
potential
industrial
pharmaceutical
applications.
In
this
review,
the
most
recent
advances
visible
(2021-till
date)
been
highlighted.
