Construction of isoindolin-1-ones via tandem reaction of ester-functionalized aziridines with amines

Synthetic Communications, Год журнала: 2024, Номер unknown, С. 1 - 8

Опубликована: Ноя. 21, 2024

We have developed a tandem reaction of ester-functionalized aziridines with secondary amines for the construction isoindolin-1-ones. Its mechanism involves sequential ring opening and lactamization. The novel features this include high efficiency, broad substrate scope mild conditions.

Язык: Английский

Recent Breakthroughs in Ring-Opening Annulation Reactions of Aziridines

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Aziridine is a fascinating core which enables synthesis of diverse N-heterocycles comprising natural product analogs and pharmaceutical candidates.

Язык: Английский