Construction of isoindolin-1-ones via tandem reaction of ester-functionalized aziridines with amines

Synthetic Communications, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Nov. 21, 2024

We have developed a tandem reaction of ester-functionalized aziridines with secondary amines for the construction isoindolin-1-ones. Its mechanism involves sequential ring opening and lactamization. The novel features this include high efficiency, broad substrate scope mild conditions.

Language: Английский

Recent Breakthroughs in Ring-Opening Annulation Reactions of Aziridines

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Aziridine is a fascinating core which enables synthesis of diverse N-heterocycles comprising natural product analogs and pharmaceutical candidates.

Language: Английский