Direct Synthesis of α-Ketothioamide Derivatives through a One-Pot Reaction of Sulfur Ylides, Nitrosobenzenes, and Thioacetic Acid

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8878 - 8887

Опубликована: Июнь 7, 2024

A one-pot approach has been developed for the synthesis of α-ketothioamide derivatives from sulfur ylides, nitrosobenzenes, and thioacetic acid. This protocol is carried out under mild reaction conditions in generally moderate to excellent yields without any precious catalysts, affording with structural diversity. Additionally, a possible mechanism this chemical transformation proposed.

Язык: Английский

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Au(PPh₃)Cl/AgOTf/TsOH-Catalyzed Cascade Reaction between 1-(2-Hydroxyphenyl)-propargyl Alcohols and β-Oxoketones (Amides, Acid): Diastereoselective Construction of cis-3a,8a-Dihydrofuro[2,3-b]benzofuran Framework

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

In the Au(PPh

Язык: Английский

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The Synthesis of Benzazepines via Sequential [3 + 2]-Annulation and [3,3]-Sigmatropic Rearrangement

Organic Letters, Год журнала: 2024, Номер 26(48), С. 10224 - 10228

Опубликована: Ноя. 22, 2024

A novel annulation reaction of prop-2-ynylsulfonium salts with sulfur ylides and nitrosobenzenes has been developed, affording various benzazepines in moderate to good yields. Prop-2-ynylsulfonium act as C

Язык: Английский

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Synthesis of 4-Hydroxy-5-phenylaminoimidazoles through a Three-Component Reaction of Sulfur Ylides, Nitrosobenzenes, and Amidines

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(24), С. 18227 - 18234

Опубликована: Ноя. 27, 2024

A novel annulation reaction of amidines with sulfur ylides and nitrobenzenes has been developed, affording various 4-hydroxy-5-phenylaminoimidazoles in moderate to excellent yields. The have further converted into α-ketoamide imidazol-4-imine derivatives. Moreover, a plausible mechanism for this multicomponent is proposed.

Язык: Английский

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