Oxygen-Dependent Ligand-Controlled Iron-Catalyzed Chemoselective Synthesis of Olefins and Vinyl Nitriles

Organic Letters, Год журнала: 2024, Номер 26(13), С. 2540 - 2545

Опубликована: Март 28, 2024

An oxygen-dependent ligand-controlled chemoselective synthesis of vinyl nitriles and E-olefins by coupling a variety alcohols benzyl cyanides, catalyzed well-characterized, air-stable, easy-to-prepare Fe(II) catalyst (1a) bearing redox-active arylazo pincer (L1a) is reported. The azo-moiety the ligand backbone acts as an electron hydrogen reservoir, enabling 1a to efficiently produce broad spectrum in moderate good yields selectively under oxygen argon atmosphere, respectively.

Язык: Английский

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Green Chemistry’s Contribution to the Kamal Qureshi Protocol: Comparing Various Activating Modes, the Use of Bentonitic Clay as the Catalyst, and the Use of a Green Solvent

Catalysts, Год журнала: 2025, Номер 15(3), С. 238 - 238

Опубликована: Март 1, 2025

After attending both the “Decade to Educate in Sustainable Development and Agenda 30 of UNESCO” “ACS GCI Pharmaceutical Roundtable”, which focused on sustainable chemistry, this article, a green chemistry contribution Kamal Qureshi protocol is offered; thus, DIM® several its analogs (3,3′-diindolylmethanes) were suitably produced under protocol. In first stage, substrate indol-3-yl carbinol was evaluated using mechanochemistry (the best mode) comparison other activating methods (near-infrared microwave electromagnetic irradiation ultrasound), wishing highlight employment TAFF®, an excellent well-characterized natural catalyst (bentonitic clay), acetone, solvent, addition analysis procedures real-time. second mechanochemical methodology extended produce set fifteen DIMs, last use metric exhibited greenness approach, with it being important that, our knowledge, after search literature, time that process has been demonstrate greenness.

Язык: Английский

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Hydrogen-Bond-Assisted Ru(III)-Catalyzed C–C Bond Activation in 1,3-Dicarbonyls: A Direct Route to Multi-Substituted Pyrroles

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Unprecedented CO-Cα bond cleavage of 1,3-dicarbonyls and enaminone, catalyzed by a well-defined Ru(III)-complex (1) featuring redox-active triamine ligand (L1) with free -NH2 arm, opening new route to accessing substituted pyrroles broad substrate scope functional group tolerance in good isolated yields via multicomponent coupling 1,3-dicarbonyls, amines, diol, is reported. The hydrogen bonding interaction offered 1 facilitates the formation critical reaction intermediates, favoring pyrroles.

Язык: Английский

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MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

ChemistrySelect, Год журнала: 2024, Номер 9(33)

Опубликована: Авг. 28, 2024

Abstract Herein, we present an efficient, one‐pot reaction for accessing 3‐benzylated indoles via the coupling of benzyl alcohols with under heterogeneous catalysis by manganese ferrite (MnFe 2 O 4 ) nanoparticles. Notably, this reaction, first time, employs MnFe nanoparticles prepared using a simple grinding method. The high compatibility enables broad substrate scope and regioselectivity. Moreover, approach offers several attractive highlights including use recyclable oxide catalyst green cost‐effective alkylating reagents solvent‐free conditions.

Язык: Английский

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Fe(II)-Catalyzed Metal-Ligand Cooperative Approach for Selective C3-Alkylation of Indoles

Synlett, Год журнала: 2024, Номер 35(20), С. 2508 - 2514

Опубликована: Авг. 12, 2024

Abstract Herein, we report a straightforward approach for synthesizing C3-alkylated indoles selectively via an iron-catalyzed alkylation of using alcohols as the alkylating agents. A well-defined, air-stable, and easy-to-prepare Fe(II) catalyst redox-active tridentate arylazo scaffold was used catalyst. Various were prepared in moderate to good isolated yields by coupling with different substituted alcohols. The methodology is compatible gram-scale synthesis. Control experiments performed unveil mechanism, which revealed that reaction proceeds borrowing-hydrogen pathway where coordinated azo-aromatic ligand actively participates during catalysis, acting electron hydrogen reservoir.

Язык: Английский

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An effective alliance for successful coupling: electrochemical alcohol oxidation mediated conversion of indoles to bis(indolyl)methanes

Journal of Applied Electrochemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Язык: Английский

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Ruthenium catalyzed dehydrogenative α-C–H functionalization of β-naphthol using alcohols: a metal–ligand cooperative borrowing hydrogen approach

Catalysis Science & Technology, Год журнала: 2024, Номер 14(12), С. 3540 - 3549

Опубликована: Янв. 1, 2024

Chemoselective α-C–H functionalization of β-naphthol is achieved with inexpensive and readily available alcohols using a well-defined, air-stable, easy-to-prepare Ru( ii )-catalyst (1a) bearing redox-active tridentate pincer ( L 1a).

Язык: Английский

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