Green Chemistry’s Contribution to the Kamal Qureshi Protocol: Comparing Various Activating Modes, the Use of Bentonitic Clay as the Catalyst, and the Use of a Green Solvent

Catalysts, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238

Published: March 1, 2025

After attending both the “Decade to Educate in Sustainable Development and Agenda 30 of UNESCO” “ACS GCI Pharmaceutical Roundtable”, which focused on sustainable chemistry, this article, a green chemistry contribution Kamal Qureshi protocol is offered; thus, DIM® several its analogs (3,3′-diindolylmethanes) were suitably produced under protocol. In first stage, substrate indol-3-yl carbinol was evaluated using mechanochemistry (the best mode) comparison other activating methods (near-infrared microwave electromagnetic irradiation ultrasound), wishing highlight employment TAFF®, an excellent well-characterized natural catalyst (bentonitic clay), acetone, solvent, addition analysis procedures real-time. second mechanochemical methodology extended produce set fifteen DIMs, last use metric exhibited greenness approach, with it being important that, our knowledge, after search literature, time that process has been demonstrate greenness.

Language: Английский

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Oxygen-Dependent Ligand-Controlled Iron-Catalyzed Chemoselective Synthesis of Olefins and Vinyl Nitriles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(13), P. 2540 - 2545

Published: March 28, 2024

An oxygen-dependent ligand-controlled chemoselective synthesis of vinyl nitriles and E-olefins by coupling a variety alcohols benzyl cyanides, catalyzed well-characterized, air-stable, easy-to-prepare Fe(II) catalyst (1a) bearing redox-active arylazo pincer (L1a) is reported. The azo-moiety the ligand backbone acts as an electron hydrogen reservoir, enabling 1a to efficiently produce broad spectrum in moderate good yields selectively under oxygen argon atmosphere, respectively.

Language: Английский

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Hydrogen-Bond-Assisted Ru(III)-Catalyzed C–C Bond Activation in 1,3-Dicarbonyls: A Direct Route to Multi-Substituted Pyrroles

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Unprecedented CO-Cα bond cleavage of 1,3-dicarbonyls and enaminone, catalyzed by a well-defined Ru(III)-complex (1) featuring redox-active triamine ligand (L1) with free -NH2 arm, opening new route to accessing substituted pyrroles broad substrate scope functional group tolerance in good isolated yields via multicomponent coupling 1,3-dicarbonyls, amines, diol, is reported. The hydrogen bonding interaction offered 1 facilitates the formation critical reaction intermediates, favoring pyrroles.

Language: Английский

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Mn(I)‐NNSe Pincer Complex Catalyzed Regioselective Synthesis of Bisindolylmethanes under Base and Solvent‐Free Conditions

Asian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract Here, we present a catalytic, regioselective synthesis of bisindolylmethanes through the reaction indoles and benzyl alcohol derivatives mediated by metal‐ligand cooperative catalysis. The is catalyzed an earth‐abundant manganese‐NNSe pincer complex without need for base, solvent, additives, or hydrogen acceptors yielding water dihydrogen as environmentally friendly by‐products. Notably, C‐3 N ‐alkylation indole, commonly observed in similar reactions were not detected. Mechanistic studies suggest that catalysis Mn(I)‐NNSe initiates conversion to benzaldehyde elimination, which subsequently facilitates bisindolylmethane derivatives. To highlight practical utility this method, wide range substrates can be activated with low catalyst loading under mild conditions.

Language: Английский

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MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(33)

Published: Aug. 28, 2024

Abstract Herein, we present an efficient, one‐pot reaction for accessing 3‐benzylated indoles via the coupling of benzyl alcohols with under heterogeneous catalysis by manganese ferrite (MnFe 2 O 4 ) nanoparticles. Notably, this reaction, first time, employs MnFe nanoparticles prepared using a simple grinding method. The high compatibility enables broad substrate scope and regioselectivity. Moreover, approach offers several attractive highlights including use recyclable oxide catalyst green cost‐effective alkylating reagents solvent‐free conditions.

Language: Английский

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Fe(II)-Catalyzed Metal-Ligand Cooperative Approach for Selective C3-Alkylation of Indoles

Synlett, Journal Year: 2024, Volume and Issue: 35(20), P. 2508 - 2514

Published: Aug. 12, 2024

Abstract Herein, we report a straightforward approach for synthesizing C3-alkylated indoles selectively via an iron-catalyzed alkylation of using alcohols as the alkylating agents. A well-defined, air-stable, and easy-to-prepare Fe(II) catalyst redox-active tridentate arylazo scaffold was used catalyst. Various were prepared in moderate to good isolated yields by coupling with different substituted alcohols. The methodology is compatible gram-scale synthesis. Control experiments performed unveil mechanism, which revealed that reaction proceeds borrowing-hydrogen pathway where coordinated azo-aromatic ligand actively participates during catalysis, acting electron hydrogen reservoir.

Language: Английский

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Ruthenium catalyzed dehydrogenative α-C–H functionalization of β-naphthol using alcohols: a metal–ligand cooperative borrowing hydrogen approach

Catalysis Science & Technology, Journal Year: 2024, Volume and Issue: 14(12), P. 3540 - 3549

Published: Jan. 1, 2024

Chemoselective α-C–H functionalization of β-naphthol is achieved with inexpensive and readily available alcohols using a well-defined, air-stable, easy-to-prepare Ru( ii )-catalyst (1a) bearing redox-active tridentate pincer ( L 1a).

Language: Английский

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An effective alliance for successful coupling: electrochemical alcohol oxidation mediated conversion of indoles to bis(indolyl)methanes

Journal of Applied Electrochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

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