Reactivities of tertiary phosphines towards allenic, acetylenic, and vinylic Michael acceptors DOI Creative Commons
Feng An, Jan Brossette, Harish Jangra

и другие.

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Combined experimental and quantum-chemical studies were used to characterise the philicity/fugality features of tertiary phosphines Michael acceptors in phospha-Michael reactions, which are key steps phosphine-catalysed organic reactions.

Язык: Английский

Phosphine‐Catalyzed Synthesis and Cytotoxic Evaluation of Michael Adducts of the Sesquiterpene Lactone Arglabin DOI
Alexey V. Salin,

Andrey A. Shabanov,

Khasan R. Khayarov

и другие.

ChemMedChem, Год журнала: 2024, Номер 19(12)

Опубликована: Март 22, 2024

A general method for chemo- and diastereoselective modification of anticancer natural product arglabin with nitrogen- carbon-centered pronucleophiles under the influence nucleophilic phosphine catalysts was developed. The locked s-cis-geometry α-methylene-γ-butyrolactone moiety favors additional stabilization zwitterionic intermediate by electrostatic interaction between phosphonium enolate oxygen centers, leading to unprecedentedly high efficiency phosphine-catalyzed Michael additions this sesquiterpene lactone. Using n-Bu

Язык: Английский

Процитировано

2
Reactivities of tertiary phosphines towards allenic, acetylenic, and vinylic Michael acceptors DOI Creative Commons
Feng An, Jan Brossette, Harish Jangra

и другие.

Chemical Science, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Combined experimental and quantum-chemical studies were used to characterise the philicity/fugality features of tertiary phosphines Michael acceptors in phospha-Michael reactions, which are key steps phosphine-catalysed organic reactions.

Язык: Английский

Процитировано

1