Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
A
simple
and
efficient
strategy
for
the
synthesis
of
structurally
diverse
β,β-diarylmethine
substituted
isoxazoline
derivatives
have
been
developed.
This
approach
employs
a
manganese-promoted
oxidative
cyclization
coupled
with
1,6-conjugate
addition
unsaturated
oximes
to
p-quinone
methides.
The
key
features
this
study
include
formation
C-O
C-C
bonds
through
intramolecular
intermolecular
interactions,
facilitated
by
in
situ
generated
iminoxyl
radicals.
isoxazolines,
bearing
wide
range
functional
groups,
were
isolated
high
yields.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10614 - 10623
Опубликована: Июль 25, 2024
A
photocatalyst-free
and
EDA
complex-enabled
radical
cascade
cyclization
reaction
of
inactive
alkenes
with
bromodifluoroacetamides
was
reported
for
the
divergent
synthesis
fluorine-containing
tetralones
quinazolinones.
In
this
transformation,
persulfates
as
electron
donors
difluoro
bromamide
acceptors
generate
complex.
This
is
a
promising
photochemical
method
advantages
such
mild
conditions,
simple
operation,
being
metal-free,
excellent
functional
group
tolerance.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(6)
Опубликована: Апрель 18, 2024
Abstract
Electron‐donor
acceptor
(EDA)
complex
has
been
an
integral
part
of
visible‐light
photocatalysis
and
is
different
from
the
traditional
photoredox
catalysis,
which
requires
exogenous
photocatalyst,
typically
a
colored
compound
to
initiate
photocatalytic
cycle.
Interestingly,
EDA‐complex
photochemistry
found
profound
use
in
activating
inert
α‐C−H
bonds
amines.
The
strategy
relied
upon
formation
between
donor
(amine)
(Lewis
acid),
harvesting
light
energy
perform
SET
process
generate
radical
cation
anion
intermediates.
then
loses
activated
acidic
proton
(because
SET,
acidity
α‐proton
increases
by
lowering
BDE)
form
α‐amino
radical,
participates
various
C−C
coupling
cascades.
In
this
review,
conceptual
approaches
for
generation
radicals
their
bond‐forming
reaction
under
triggered
will
be
discussed
with
particular
emphasis
on
mechanism
2018
onwards.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 13, 2024
Abstract
A
visible‐light‐promoted
strategy
for
the
decarboxylative
C‐3
carbamoylation
of
quinoxalinone
scaffolds
is
developed.
This
approach
initiates
through
formation
an
EDA
complex
between
oxamic
acid
and
quinoxalinone.
Successive
SET
construct
C−C
bond.
method
utilizes
aerial
oxygen
as
green
oxidant
eradicates
process
from
use
external
photocatalysts
transition
metals.
Detailed
synthetic
photophysical
studies
enlighten
reaction
pathway.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Herein,
an
efficient
aerobic
cross-coupling
of
quinoxazolines
with
electron-rich
thiophenes
was
presented.
It's
easy
and
effective
access
to
3-thiophenyl
quinoxalinones
without
external
photo-catalyst
or
transition-metal
catalyst.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(8)
Опубликована: Май 22, 2024
Abstract
The
formation
of
carbon‐nitrogen
bonds
holds
paramount
importance
in
the
realm
synthetic
organic
chemistry,
finding
extensive
applications
synthesis
pharmaceuticals,
agrochemicals,
and
materials.
Herein,
we
describe
a
novel
EDA
complex
mediated,
metal‐
photocatalyst‐free,
visible‐light‐initiated
direct
C‐3
amination
biologically
important,
quinoxalin‐2(1
H
)‐one
moiety.
key
to
success
lies
photoactivated
electron
donor‐acceptor
between
amine,
which
undergo
subsequent
transfer
reaction
effect
desired
transformation.
A
diverse
array
3‐aminoquinoxalin‐2(1
)‐ones
were
prepared
employing
this
process
yields
are
up
87%.
This
work
represents
significant
advancement
toward
more
environmentally
friendly
efficient
approach,
characterized
by
mild
conditions
high
atom
economy.
Abstract
A
widely
used
method
to
obtain
tetrazoles
is
through
the
azide
and
nitrile
[3+2]
cycloaddition.
However,
this
process
often
involves
using
non‐recyclable
transition
metals
or
Lewis
acid
catalysts
stoichiometric
amounts
of
oxidants
additives,
which
reduces
atom
efficiency.
We
have
discovered
a
convergent
paired
electrochemical
reaction
perform
cycloaddition
reaction,
without
need
for
metal
oxidants.
This
tetrazolation
strategy
uses
azidotrimethylsilane
(TMSN
3
)
N
‐heterocycles
in
an
undivided
cell
at
constant
current.
use
mixture
CH
CN
equivalent
H
2
O
as
co‐solvent
room
temperature.
It
crucial
produce
amount
active
hydroxyl
ions
cathodic
reduction
water.
Cyclic
voltammetry
(CV)
studies
control
experiments
confirm
that
specific
electrode
electron
transfer
process,
eliminating
mediator
shuttle
electrons.
metal‐
oxidant‐free
highly
compatible
with
different
functional
groups
produces
products
moderate
good
yields.
successfully
tetrazolated
bioactive
compounds
late
stage,
scaled
up
batches
efficiently,
synthesized
free
amino‐containing
via
denitrogenation
tetrazoles.
