Metal(loid)s, nitrate, polycyclic aromatic hydrocarbons, and radioactive contaminants in Nigerian water resources: state-of-the-art of their ecological and health risk assessments

Environment Development and Sustainability, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Язык: Английский

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Green synthesis of copper doped bismuth oxide: A novel inorganic material for photocatalytic mineralization of Trypan blue dye

Inorganic Chemistry Communications, Год журнала: 2024, Номер 163, С. 112270 - 112270

Опубликована: Март 12, 2024

Язык: Английский

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Thiosemicarbazone derivatives as potent antidiabetic agents: Synthesis, in vitro, molecular docking and DFT investigations

Journal of Molecular Structure, Год журнала: 2024, Номер 1311, С. 138459 - 138459

Опубликована: Апрель 28, 2024

Язык: Английский

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Magnetic nanomaterials as green and recoverable nanocatalysts: Research on synthesis of benzimidazole derivatives

Synthetic Communications, Год журнала: 2024, Номер 54(9), С. 709 - 734

Опубликована: Март 28, 2024

Research on benzimidazole derivatives is always an attractive challenge among synthetic chemists because are very key and important components in the structure of many drugs, biological active molecules, natural products. Benzimidazole interesting their valuable medicinal activities, such as anti-bacterial, anti-cancer, anti-tuberculosis, anti-fungal, pain killer, anti-HIV activities. During last decade, most reports field catalysts have been related to magnetic nanocatalysts, which shows high popularity remarkable efficiency this type catalyst performing chemical reactions. Magnetic nanocatalysts ideal both from point view green chemistry economically they easily separated reaction mixture significant catalytic activity. In review article, we summarized methods presented synthesis various based use nanomaterials recoverable catalysts.

Язык: Английский

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Electrochemical and Photocatalytic Synthesis of Organic Compounds Utilizing a Greener Approach. A review

Molecular Catalysis, Год журнала: 2024, Номер 559, С. 114087 - 114087

Опубликована: Апрель 1, 2024

Язык: Английский

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Designing and Synthesis of Novel Fexofenadine‐Derived Hydrazone‐Schiff bases as Potential Urease Inhibitors: In‐Vitro, Molecular Docking and DFT Investigations

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(8)

Опубликована: Май 23, 2024

Thirteen novel hydrazone-Schiff bases (3-15) of fexofenadine were succesfully synthesized, structurally deduced and finally assessed their capability to inhibit urease enzyme (in vitro). In the series, six compounds 12 (IC

Язык: Английский

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Design, synthesis, molecular docking study, and α-glucosidase inhibitory evaluation of novel hydrazide–hydrazone derivatives of 3,4-dihydroxyphenylacetic acid

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 18, 2024

Abstract A series of novel Schiff base derivatives (1–28) 3,4-dihydroxyphenylacetic acid were synthesized in a multi-step reaction. All the bases obtained high yields and their structures determined by 1 HNMR, 13 CNMR, HR-ESI–MS spectroscopy. Except for compounds 22 , 26 27, 28, all show excellent to moderate α-glucosidase inhibition. Compounds 5 (IC 50 = 12.84 ± 0.52 µM), 4 13.64 0.58 12 15.73 0.71 16.62 0.47 15 17.40 0.74 3 18.45 1.21 7 19.68 0.82 2 20.35 1.27 µM) shows outstanding inhibition as compared standard acarbose 873.34 1.67 µM). Furthermore, docking study was performed find out interaction between enzyme most active compounds. With this research work, have been introduced potential class inhibitors that remained elusive till now.

Язык: Английский

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Construction and characterization of a magnetic nanoparticle-supported Cu complex: a stable and active nanocatalyst for synthesis of heteroaryl-aryl and di-heteroaryl sulfides

RSC Advances, Год журнала: 2024, Номер 14(2), С. 812 - 830

Опубликована: Янв. 1, 2024

Growing demand for eco-friendly catalysts in drug synthesis. Fe 3 O 4 @AMBA-CuI nanomaterials, a reusable catalyst, enable synthesis of diaryl and di-heteroaryl sulfides from diverse substrates. Reusability tests confirm stability, maintaining magnetic properties through six uses, yielding sulfides.

Язык: Английский

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Green Synthesis and Characterization of Silver Nanoparticles Using Azadirachta indica Seeds Extract: In Vitro and In Vivo Evaluation of Anti-Diabetic Activity

Pharmaceuticals, Год журнала: 2023, Номер 16(12), С. 1677 - 1677

Опубликована: Дек. 1, 2023

Diabetes mellitus (DM) is a non-communicable, life-threatening syndrome that present all over the world. The use of eco-friendly, cost-effective, and green-synthesised nanoparticles as medicinal therapy in treatment DM an attractive option.In study, silver (AI-AgNPs) were biosynthesized through green synthesis method using Azadirachta indica seed extract to evaluate their anti-diabetic potentials.These characterized by UV-visible spectroscopy, Fourier transform infrared spectrophotometers (FTIR), scanning electron microscopy (SEM), DLS, X-ray diffraction (XRD). AI-AgNPs crude extracts seeds evaluated for potentials glucose adsorption assays, uptake yeast cells alpha-amylase inhibitory assays.Al-AgNPs showed highest activity (75 ± 1.528%), while (63 2.5%) at 80 µg/mL. In assay, Al-AgNPs was 10.65 1.58%, 8.32 0.258% 30 mM, whereas exhibited maximum 73.85 1.114% 65.85 2.101% 100 assay results substantial dose-dependent activities. Further, also investigated streptozotocin-induced diabetic mice. Mice administered with (10 40 mg/kg b.w) days.The considerable drop blood sugar levels, including pancreatic liver cell regeneration, demonstrating have strong potential.

Язык: Английский

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Discovering the anti-diabetic potential of thiosemicarbazone derivatives: In vitro α-glucosidase, α-amylase inhibitory activities with molecular docking and DFT investigations

Journal of Molecular Structure, Год журнала: 2024, Номер 1312, С. 138671 - 138671

Опубликована: Май 19, 2024

Язык: Английский

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