Electrochemical Oxidative Reassembly of 1,3-Diketones with Aryl Alkenes and Water via Carbon–Carbon Bond Cleavage Rearrangement
Wei Wu,
R.K. Linghu,
Bingjie Jian
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
We
report
the
electrochemical
cleavage
and
reassembly
of
1,3-diketones
with
aryl
alkenes
water
for
synthesis
1,4-ketoalcohol
derivatives.
This
approach
represents
first
example
formal
carbon-carbon
alkene
insertion
via
electro-oxidation,
enabling
direct
diverse
derivatives
in
good
to
high
yields.
The
developed
strategy
employs
an
using
inexpensive
commercial
carbon
electrodes
undivided
cell
under
mild
operationally
simple
conditions.
Язык: Английский
Cu(I)-Catalyzed Three-Component Annulation for the Synthesis of 3-Acyl Imidazo[1, 5-a]Pyridines from 2-Pyridinyl-Substituted p-Quinone Methides, Terminal Alkynes, and TsN3 Using O2 as the Oxygen Source
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(8), С. 5423 - 5433
Опубликована: Апрель 1, 2024
Currently,
most
conventional
methods
to
achieve
imidazo[1,5-a]pyridines
have
limitations
for
the
synthesis
of
3-acyl
imidazo[1,5-a]pyridines.
Herein,
a
novel
and
efficient
Cu(I)-catalyzed
three-component
annulation
method
valuable
by
reaction
2-pyridinyl-substituted
p-QMs,
terminal
alkynes,
TsN3
in
presence
O2
under
mild
conditions
successfully
been
developed.
The
investigation
indicated
that
molecular
oxygen
(O2)
TsN3,
respectively,
serving
as
nitrogen
sources,
were
essential
successful
completion
system.
Язык: Английский