A Domino Decarboxylative Alkylation/Annulation for the Synthesis of Pyrrolo-benzimidazolones

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The reaction of N -propiolyl-benzimidazole with aliphatic carboxylic acids in the presence ammonium persulfate leading to pyrrolo-benzimidazolones is presented.

Язык: Английский

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Dearomatization of Aromatic Compounds: A Decade Review

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Dearomatization offers an efficient strategy for directly converting arenes into cyclic molecules. In this review, we discuss representative examples of dearomatization reactions through five modes: (1) radical dearomatization, (2) halofunctionalization‐dearomatization, in which three‐membered intermediates were frequently involved, (3) nucleophilic mainly about electron‐rich arenes, (4) oxidative and (5) reductive dearomatization. Compared to heteroarenes, simple benzene are more challenging participate reactions. recent years, fewer reports have focused on benzene. Heteroarenes, inherently or easily activated, tend undergo readily. This review highlights a decade progress including indoles, benzofurans, benzothiophenes, thiophenes, furans, naphthols, naphthalenes, quinolines, pyridines, nitrobenzenes, benzenes. It also analyzes their mechanisms strategies. We hope will aid future research field.

Язык: Английский

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Electrochemical selenylative ipso-Annulation of N-benzylacrylamides to seleno-azaspiro[4.5]decadienones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(30), С. 6141 - 6148

Опубликована: Янв. 1, 2024

Construction of seleno azaspiro[4.5]decadienones using an electrochemical approach is achieved via domino selenylation/ ipso -annulation.

Язык: Английский

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Reactions of alkynes with C–S bond formation: recent developments

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(32), С. 6443 - 6484

Опубликована: Янв. 1, 2024

Alkynes are important in organic synthesis. This review mainly focuses on the recent advances (2013–2023) alkynes with C–S bond formation, based more than 30 kinds of sulfur reagents.

Язык: Английский

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Carbonylative Cyclization of Biaryl Enones with Aldehydes and Oxamic Acids

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(24), С. 4901 - 4911

Опубликована: Янв. 1, 2024

An oxidative radical-promoted carbonylative cyclization strategy for the synthesis of phenanthren-9-(10

Язык: Английский

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A Review on Functionalization of Benzo‐5,6‐Fused Bicyclic Heteroaromatic Compounds

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(22)

Опубликована: Июль 16, 2024

Abstract Over the decades, functionalized heteroaromatic compounds and their scaffolds have drawn significant attention in synthetic organic chemistry as well interdisciplinary sciences due to prevalence natural products, hormones, vitamins, applications pharmaceuticals, agrochemicals, veterinary dyes pigments, bio‐imaging, semiconductors, optoelectronics, etc. This review explores various strategies for functionalization of numerous 5,6 benzo‐fused derivatives such indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, benzothiazole benzotriazole through methods including C−H activation, cross‐coupling, metal catalysis, photo‐catalysis, electrocatalysis organocatalysis recent years (2019–2023). Highly heterocyclic are important precursors synthesizing many bioactive drugs like fenbendazole, viozan, griseofulvin, zileuton, flunoxaprofen, optoelectronic materials,

Язык: Английский

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Entry to 4,5-Fused Coumarin frameworks via Radical-Promoted Alkylative Intramolecular C5-Annulation

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(31), С. 6385 - 6392

Опубликована: Янв. 1, 2024

A silver-catalyzed oxidative protocol for the synthesis of previously unfamiliar 4,5-fused coumarins is disclosed.

Язык: Английский

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Iodo-Annulations of N-Benzyl-propiolamides Leading To Azaspiro[5.5]undecatrienones or Benzo[c]azepinones

Synthesis, Год журнала: 2024, Номер 56(19), С. 3037 - 3044

Опубликована: Июнь 20, 2024

Abstract Iodine-mediated oxidative annulations of N-benzyl-propiolamides are disclosed for the first time, providing either azaspiro[5.5]undecatrienones via dearomative ipso-annulation or benzo[c]azepinones through ortho-annulation. The selective construction aforementioned products is based on ceric ammonium nitrate (CAN)-promoted divergent reactivity propiolamide, directed by substituents phenyl ring N-benzyl group.

Язык: Английский

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Acid-Mediated Intramolecular Cyclizations of (N-Aryl)-acetylenic Sulfonamides: Synthesis of Fused and Spirocyclic Sultams

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 14, 2024

Herein, we report acid-mediated divergent annulations of (

Язык: Английский

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Highly Selective Synthesis of Selenium-Containing (E)-N-Propenolquinazolinones via FeCl3-Mediated Cascade Reaction of Propargyl Quinazoline-4-yl Ethers with Diselenides

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

An effective approach for the highly selective synthesis of selenium-containing ( E )- N -propenolquinazolinones via an FeCl 3 ·6H 2 O mediated cascade reaction propargyl quinazoline-4-yl ethers and diselenides has been developed.

Язык: Английский

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