Ni-Catalyzed Regioselective Alkylarylation of Unactivated Alkenes in Amines Enabled by Cooperative Ligand Effects of Nitriles and Electron-Deficient Alkenes
Vivek Aryal,
Supuni I. N. Hewa Inaththappulige,
Ayush Acharya
и другие.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(2), С. 1667 - 1676
Опубликована: Янв. 7, 2025
We
report
a
Ni-catalyzed
vicinal
alkylarylation
of
unactivated
alkenes
in
γ,δ-
and
δ,ε-alkenylamines
with
aryl
halides
alkylzinc
reagents.
The
reaction
is
enabled
by
amine
coordination
can
use
all
primary,
secondary,
tertiary
amines.
constructs
two
new
C(sp3)-C(sp3)
C(sp3)-C(sp2)
bonds
produces
δ-
ε-arylamines
C(sp3)-branching
at
the
γ-
δ-positions.
A
variety
heteroaryl
iodides
both
primary
secondary
reagents
be
used
as
coupling
carbon
sources.
Mechanistic
studies
suggest
that
cooperative
effect
organic
nitriles
electron-deficient
(EDAs)
ligands.
Язык: Английский
Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
photochemical
radical
cascade
cyclization
reaction
of
isocyanides
with
α-carbonyl
bromides
under
mild
conditions
is
disclosed
for
accessing
1,4-dibenzodiazepines,
demonstrating
good
tolerance
towards
various
functional
groups.
Язык: Английский
Alkylcyanation of unactivated alkenes via photoinduced hydrogen atom transfer and 1,4-cyano migration
Tetrahedron Letters,
Год журнала:
2025,
Номер
159, С. 155516 - 155516
Опубликована: Фев. 27, 2025
Язык: Английский
Visible‐Light‐Mediated Catalyst and Additive‐Free C(sp3)−H Phosphorylation of Glycine Ester Derivatives
Shan Wang,
Xuefei Sha,
Zhaotian Wu
и другие.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(32)
Опубликована: Май 20, 2024
Abstract
We
herein
report
a
visible
light
induced
dehydrogenative
phosphonylation
reaction
of
glycine
derivatives
and
di‐aryl
phosphine
oxides.
A
diverse
range
phosphine‐glycine
were
constructed
under
ambient
condition
in
the
absence
catalyst
additives.
plausible
mechanism
was
also
proposed.
Язык: Английский
Photochemical Radical Cascade 6‐endo Cyclization of Dienes with α‐Carbonyl Bromides for the Synthesis of Six‐Membered Benzo‐Fused Lactams
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(19), С. 2323 - 2328
Опубликована: Май 22, 2024
Comprehensive
Summary
A
novel
visible‐light‐induced
radical
cascade
6‐
endo
cyclization
of
dienes
(
N
‐(2‐vinylphenyl)acryl
amides)
is
developed
utilizing
α‐carbonyl
bromides
as
alkyl
reagents.
This
approach
affords
an
efficient
way
for
synthesizing
six‐membered
benzo‐fused
lactam
derivatives
with
chemo‐
and
regio‐selectivity
good
functional
group
tolerance.
Primary,
secondary,
tertiary
are
well‐compatible
this
reaction.
Язык: Английский