Photochemical Radical Cascade 6‐endo Cyclization of Dienes with α‐Carbonyl Bromides for the Synthesis of Six‐Membered Benzo‐Fused Lactams DOI

Jia‐Li Sui,

Yang Guo, Biquan Xiong

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(19), P. 2323 - 2328

Published: May 22, 2024

Comprehensive Summary A novel visible‐light‐induced radical cascade 6‐ endo cyclization of dienes ( N ‐(2‐vinylphenyl)acryl amides) is developed utilizing α‐carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six‐membered benzo‐fused lactam derivatives with chemo‐ and regio‐selectivity good functional group tolerance. Primary, secondary, tertiary are well‐compatible this reaction.

Language: Английский

Ni-Catalyzed Regioselective Alkylarylation of Unactivated Alkenes in Amines Enabled by Cooperative Ligand Effects of Nitriles and Electron-Deficient Alkenes DOI

Vivek Aryal,

Supuni I. N. Hewa Inaththappulige,

Ayush Acharya

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(2), P. 1667 - 1676

Published: Jan. 7, 2025

We report a Ni-catalyzed vicinal alkylarylation of unactivated alkenes in γ,δ- and δ,ε-alkenylamines with aryl halides alkylzinc reagents. The reaction is enabled by amine coordination can use all primary, secondary, tertiary amines. constructs two new C(sp3)-C(sp3) C(sp3)-C(sp2) bonds produces δ- ε-arylamines C(sp3)-branching at the γ- δ-positions. A variety heteroaryl iodides both primary secondary reagents be used as coupling carbon sources. Mechanistic studies suggest that cooperative effect organic nitriles electron-deficient (EDAs) ligands.

Language: Английский

Citations

0
Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines DOI
Ao-Long Li,

R.-Q. Xie,

Quan Zhou

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A photochemical radical cascade cyclization reaction of isocyanides with α-carbonyl bromides under mild conditions is disclosed for accessing 1,4-dibenzodiazepines, demonstrating good tolerance towards various functional groups.

Language: Английский

Citations

0
Alkylcyanation of unactivated alkenes via photoinduced hydrogen atom transfer and 1,4-cyano migration DOI

Meichen Xu,

Pandaram Sakthivel, Zeyu Ma

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: 159, P. 155516 - 155516

Published: Feb. 27, 2025

Language: Английский

Citations

0
Visible‐Light‐Mediated Catalyst and Additive‐Free C(sp3)−H Phosphorylation of Glycine Ester Derivatives DOI

Shan Wang,

Xuefei Sha,

Zhaotian Wu

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(32)

Published: May 20, 2024

Abstract We herein report a visible light induced dehydrogenative phosphonylation reaction of glycine derivatives and di‐aryl phosphine oxides. A diverse range phosphine‐glycine were constructed under ambient condition in the absence catalyst additives. plausible mechanism was also proposed.

Language: Английский

Citations

2
Photochemical Radical Cascade 6‐endo Cyclization of Dienes with α‐Carbonyl Bromides for the Synthesis of Six‐Membered Benzo‐Fused Lactams DOI

Jia‐Li Sui,

Yang Guo, Biquan Xiong

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(19), P. 2323 - 2328

Published: May 22, 2024

Comprehensive Summary A novel visible‐light‐induced radical cascade 6‐ endo cyclization of dienes ( N ‐(2‐vinylphenyl)acryl amides) is developed utilizing α‐carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six‐membered benzo‐fused lactam derivatives with chemo‐ and regio‐selectivity good functional group tolerance. Primary, secondary, tertiary are well‐compatible this reaction.

Language: Английский

Citations

2