Chemodivergent dearomatization of benzene-linked O-oxime esters via EnT-induced radical cross-coupling
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Radical-mediated
dearomatization
strategies
offer
a
blueprint
for
building
value-added
and
synthetically
valuable
three-dimensional
skeletons
from
readily
available
aromatic
starting
materials.
Язык: Английский
Unification of Ru and carbon support in catalytic aqueous 1,6-hexanediol amination
Molecular Catalysis,
Год журнала:
2025,
Номер
578, С. 115030 - 115030
Опубликована: Март 20, 2025
Язык: Английский
Development of N-centered radical scavengers that enables photoredox-catalyzed transition-metal-free radical amination of alkyl pinacol boronates
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 4, 2025
In
recent
years,
amination
of
alkylboronates
through
ionic
copper
catalysis
or
boron-ate
complex
1,2-metalation
has
been
well
established,
but
complementary
radical
processes
remain
less
studied
before.
Herein,
based
on
rational
design,
we
develop
several
imine-type
N-centered
scavengers
and
apply
them
to
the
alkylboronates.
The
reaction
proceeds
under
mild
photoredox-catalyzed
transition-metal-free
conditions
features
excellent
functional
group
tolerance.
It
also
enables
preparation
a
range
medicinally
valuable
amine
derivatives
from
natural
products.
Further
application
this
reagent
in
C-H
amination,
deoxygenative
decarboxylative
three
component
trifluoromethylative/sulfonylative
aminations
are
realized.
mechanistic
studies
DFT
calculations
conducted
provide
detailed
evidence
for
mechanism.
Язык: Английский
Red Light and Supersilane: A Novel Pathway for Hydrofunctionalizations and Giese Reactions
ACS Organic & Inorganic Au,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 10, 2025
Язык: Английский
Photocatalyzed Formation of gem‐Difluoroalkenes Using Oxime Esters
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(16), С. 3430 - 3437
Опубликована: Апрель 10, 2024
Abstract
In
this
manuscript
a
general
photocatalytic
approach
for
the
synthesis
of
alkyl‐substituted
gem
‐difluoroalkenes
using
readily
available
oxime
esters
and
1‐bromo‐1,1‐difluoroprop‐2‐ene
(BDFP)
has
been
established.
This
strategy
involving
radical
bromo
elimination
provides
access
to
large
variety
value‐added
fluorinated
molecules.
The
mild
reaction
conditions
are
compatible
with
many
functional
groups
including
complex
natural
products
or
drug
Experimental
theoretical
mechanistic
investigations
indicate
that
efficiency
process
relies
on
crucial
role
imine
radical,
which
is
formed
after
photoexcitation
via
energy
transfert
(EnT)
decarboxylation
ester.
Indeed,
would
either
behave
as
bromine
scavenger
an
XAT
promoter
in
reaction.
Язык: Английский
Metal‐Free Decarboxylative Allylation of Oxime Esters under Light Irradiation
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(43)
Опубликована: Май 24, 2024
Allylation
reactions,
often
used
as
a
key
step
for
constructing
complex
molecules
and
drug
candidates,
typically
rely
on
transition-metal
(TM)
catalysts.
Even
though
TM-free
radical
allylations
have
been
developed
using
allyl-stannanes,
-sulfides,
-silanes
or
-sulfones,
much
less
procedures
reported
simple
commercially
available
allyl
halides,
that
are
the
preparation
of
before-mentioned
derivatives.
Here,
we
present
straightforward
photocatalytic
protocol
decarboxylative
allylation
oxime
esters
bromide
derivatives
under
metal-free
mild
conditions.
This
methodology
yields
diverse
variety
functionalized
including
several
pharmaceutically
relevant
molecules.
Язык: Английский
Light-assisted functionalization of aryl radicals towards metal-free cross-coupling
Nature Reviews Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 15, 2024
Язык: Английский
Recent advances in photoorganocatalysis (2019–2023)
Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 199 - 236
Опубликована: Дек. 18, 2024
From
2008
until
now,
the
advent
of
photochemistry
has
offered
a
plethora
synthetic
opportunities
to
chemists
worldwide.
The
ability
light
generate
reactive
species
under
mild
reaction
conditions
provided
access
unexplored
pathways.
Lately,
development
photochemical
reactions
employing
small
organic
molecules
as
catalysts
increased.
Serving
basic
principles
Green
Chemistry,
have
proven
be
an
excellent
alternative
use
metal-based
complexes,
performing
elegant
transformations.
Their
is
based
on
their
mediate
events,
such
Single
Electron
Transfer
(SET),
Energy
(EnT)
and
Hydrogen
Atom
(HAT).
Furthermore,
there
been
reports
capability
form
Donor–Acceptor
(EDA)
complexes
facilitating
challenging
Herein,
we
will
focus
promoted
by
during
last
5
years
(2019–2023).
Язык: Английский