Regioselective [3 + 2] Annulation of β,γ-Alkynyl-α-ketimino Esters with 1,3-Dicarbonyls: The Synthesis of Highly Functionalized Dihydrofurans

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

A regioselective [3 + 2] annulation of β,γ-alkynyl-α-ketimino esters with 1,3-dicarbonyls is disclosed. series Z-selective dihydrofurans bearing an exocyclic double bond and a quaternary carbon center are accessed without the usage base. Control deuterium-labeling experiments have been investigated to probe into reaction mechanism. The catalyst base-free nucleophilic addition highlights transformation.

Язык: Английский

DABCO-catalyzed mono- and bisallylation of β,γ-unsaturated ketones with Morita-Baylis-Hillman carbonates

New Journal of Chemistry, Год журнала: 2024, Номер 48(35), С. 15446 - 15451

Опубликована: Янв. 1, 2024

Mono- and bisallylation of β,γ-unsaturated ketones with MBH carbonates in the presence DABCO at rt, offered α-2-alkoxycarbonyl, α,α-di(2-alkoxycarbonyl) α,γ-di(2-alkoxycarbonyl) α,β-unsaturated moderate to excellent yields.

Язык: Английский