B/Cu Synergistic Catalysis for the Asymmetric Mannich Reaction between β,γ-Alkynyl-α-ketimino Esters and Ortho-Hydroxy Aryl Ketones DOI

Jiani Sun,

Chao‐Guo Yan, Qiao Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Herein, we present a B/Cu-catalyzed asymmetric Mannich reaction, utilizing β,γ-alkynyl-α-ketimino esters and ortho-hydroxy aryl ketones. The reaction initiates with the activation of ketones via borinic acid to form tetracoordinated enol boronate complex, followed by chiral Cu complex-assisted an electrophilic ketimino ester. also works alkyl-chained ketones, producing adducts moderate good diastereoselectivity. practical applicability is evidenced gram-scale subsequent elaboration adduct.

Язык: Английский

B/Cu Synergistic Catalysis for the Asymmetric Mannich Reaction between β,γ-Alkynyl-α-ketimino Esters and Ortho-Hydroxy Aryl Ketones DOI

Jiani Sun,

Chao‐Guo Yan, Qiao Wang

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Herein, we present a B/Cu-catalyzed asymmetric Mannich reaction, utilizing β,γ-alkynyl-α-ketimino esters and ortho-hydroxy aryl ketones. The reaction initiates with the activation of ketones via borinic acid to form tetracoordinated enol boronate complex, followed by chiral Cu complex-assisted an electrophilic ketimino ester. also works alkyl-chained ketones, producing adducts moderate good diastereoselectivity. practical applicability is evidenced gram-scale subsequent elaboration adduct.

Язык: Английский

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