Dehydrogenation of Aromatic Alcohols, Aldehydes, and Ketones Catalyzed by Cu(I) Complexes
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Herein,
we
report
that
binuclear
copper
complexes
used
as
dehydrogenative
catalysts,
combined
with
oxygen
an
oxidant
and
2,2,6,6-tetramethylpiperidinyl-1-oxide
(TEMPO)
additive,
are
capable
of
effectively
catalyzing
the
successive
dehydrogenation
aromatic
propanols
to
produce
α,β-unsaturated
aldehydes.
This
method
has
advantages
high
efficiency,
simple
operation,
oxidant.
The
reaction
mechanism
continuous
was
investigated
by
in
situ
infrared
spectroscopy
control
experiments.
process
suggested
phenylpropanol
first
oxidized
arylpropanals
then
underwent
α,β-selective
carbonyl
group
yield
protocol
provides
insights
into
design
synthesis
efficient
catalysts
for
preparation
aldehydes
propanols.
Язык: Английский
Photoinduced Site-Selective Alkylation Enabling Synthesis of C-3-Alkylated Quinoxalinone on DNA
Kyeong Seop Kim,
Junseok Ra,
Madala Hari Babu
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
A
mild
and
biocompatible
strategy
for
the
site-selective
alkylation
of
quinoxalinones
via
photoinduced
dehydrogenative
has
been
developed.
This
protocol
enables
functionalization
both
unprotected
quinoxalinone
nonreactive
dihydroquinoxalinone
under
DNA-compatible
conditions.
The
optimized
reaction
proceeds
efficiently
while
tolerating
a
diverse
range
alkyl
donors
from
various
radical
precursors.
Given
its
simplicity
DNA
compatibility,
this
methodology
offers
platform
construction
DNA-encoded
libraries
incorporating
privileged
scaffold.
Язык: Английский
Enhanced catalytic performance for aerobic dehydrogenation of N-heterocycles over bimetallic CoOX-CeO2 catalysts derived from Ce-based MOFs
Molecular Catalysis,
Год журнала:
2024,
Номер
567, С. 114450 - 114450
Опубликована: Авг. 15, 2024
Язык: Английский
Efficient CuOAc/DMAP/DEAD‐Catalyzed Aerobic Oxidative Synthesis of Quinazolines
ChemistrySelect,
Год журнала:
2024,
Номер
9(39)
Опубликована: Окт. 1, 2024
Abstract
Efficient
approaches
toward
the
synthesis
of
quinazolines
and
dihydroisoquinolines
have
been
developed
through
copper‐catalyzed
aerobic
oxidative
dehydrogenation
N
‐heterocycles.
The
was
achieved
azodicarboxylate
esters‐mediated
amines.
Azodicarboxylate
esters
could
be
regenerated
from
corresponding
hydrazodicarboxylate
esters,
which
made
this
catalytic
process
more
efficient
reactive.
Язык: Английский
Construction of Spiro[pyrrolidine-azlactone] via [2 + 3] Cycloaddition of Alkylidene Azlactone with Trifluoromethylated Imine
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
A
Ag-catalyzed
[2
+
3]
cycloaddition
of
alkylidene
azlactones
with
trifluoromethylated
imines
has
been
documented,
providing
spiro[pyrrolidine-azlactones]
bearing
four
adjacent
stereogenic
centers
good
yields
and
excellent
diastereoselectivities.
Catalytic
asymmetric
also
developed
enantioselectivities.
Further
gram-scale
preparation
synthetic
transformation
to
pyrrolidine
derivative
showed
the
practicality
applicability
this
reaction.
Язык: Английский