Construction of Spiro[pyrrolidine-azlactone] via [2 + 3] Cycloaddition of Alkylidene Azlactone with Trifluoromethylated Imine DOI

Lesong Li,

Xia Wang, Yang Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

A Ag-catalyzed [2 + 3] cycloaddition of alkylidene azlactones with trifluoromethylated imines has been documented, providing spiro[pyrrolidine-azlactones] bearing four adjacent stereogenic centers good yields and excellent diastereoselectivities. Catalytic asymmetric also developed enantioselectivities. Further gram-scale preparation synthetic transformation to pyrrolidine derivative showed the practicality applicability this reaction.

Language: Английский

Dehydrogenation of Aromatic Alcohols, Aldehydes, and Ketones Catalyzed by Cu(I) Complexes DOI
Yangyang Shen, Xiaobin Li,

Fei Chen

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Herein, we report that binuclear copper complexes used as dehydrogenative catalysts, combined with oxygen an oxidant and 2,2,6,6-tetramethylpiperidinyl-1-oxide (TEMPO) additive, are capable of effectively catalyzing the successive dehydrogenation aromatic propanols to produce α,β-unsaturated aldehydes. This method has advantages high efficiency, simple operation, oxidant. The reaction mechanism continuous was investigated by in situ infrared spectroscopy control experiments. process suggested phenylpropanol first oxidized arylpropanals then underwent α,β-selective carbonyl group yield protocol provides insights into design synthesis efficient catalysts for preparation aldehydes propanols.

Language: Английский

Citations

0
Photoinduced Site-Selective Alkylation Enabling Synthesis of C-3-Alkylated Quinoxalinone on DNA DOI

Kyeong Seop Kim,

Junseok Ra,

Madala Hari Babu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

A mild and biocompatible strategy for the site-selective alkylation of quinoxalinones via photoinduced dehydrogenative has been developed. This protocol enables functionalization both unprotected quinoxalinone nonreactive dihydroquinoxalinone under DNA-compatible conditions. The optimized reaction proceeds efficiently while tolerating a diverse range alkyl donors from various radical precursors. Given its simplicity DNA compatibility, this methodology offers platform construction DNA-encoded libraries incorporating privileged scaffold.

Language: Английский

Citations

0
Efficient CuOAc/DMAP/DEAD‐Catalyzed Aerobic Oxidative Synthesis of Quinazolines DOI
Yue Ji,

Ze‐Lin Dang,

Menglong Niu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(39)

Published: Oct. 1, 2024

Abstract Efficient approaches toward the synthesis of quinazolines and dihydroisoquinolines have been developed through copper‐catalyzed aerobic oxidative dehydrogenation N ‐heterocycles. The was achieved azodicarboxylate esters‐mediated amines. Azodicarboxylate esters could be regenerated from corresponding hydrazodicarboxylate esters, which made this catalytic process more efficient reactive.

Language: Английский

Citations

0
Enhanced catalytic performance for aerobic dehydrogenation of N-heterocycles over bimetallic CoOX-CeO2 catalysts derived from Ce-based MOFs DOI
Zhixian Wang,

Ruibi Zhao,

Wenjing Li

et al.

Molecular Catalysis, Journal Year: 2024, Volume and Issue: 567, P. 114450 - 114450

Published: Aug. 15, 2024

Language: Английский

Citations

0
Construction of Spiro[pyrrolidine-azlactone] via [2 + 3] Cycloaddition of Alkylidene Azlactone with Trifluoromethylated Imine DOI

Lesong Li,

Xia Wang, Yang Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

A Ag-catalyzed [2 + 3] cycloaddition of alkylidene azlactones with trifluoromethylated imines has been documented, providing spiro[pyrrolidine-azlactones] bearing four adjacent stereogenic centers good yields and excellent diastereoselectivities. Catalytic asymmetric also developed enantioselectivities. Further gram-scale preparation synthetic transformation to pyrrolidine derivative showed the practicality applicability this reaction.

Language: Английский

Citations

0