Electro-induced C-H/S-H Cross-Coupling for the Functionalization/Macrocyclization of Cysteine-Containing Peptides
Опубликована: Апрель 7, 2025
Abstract
The
electrochemical
platform
that
underpins
the
promising
future
of
selective
modifications
peptides
and
proteins,
however,
is
still
rather
underdeveloped.
Here
in,
an
electro-induced
umpolung
approach
enables
efficient
functionalization/macrocyclization
cysteine-containing
reported.
Notably,
this
method
utilizes
simple
halogen
source
takes
metal-mediated
atom
transfer
as
main
pathway
to
enable
in-situ
polarity
reversal,
highlighting
unique
possibilities
associated
with
activation
methods.
Under
mild
conditions,
cysteine
residue
can
be
well-labelled
high
chemo-selectivity
excellent
conversion.
This
transformation
tolerate
a
wide
range
valuable
enamines,
azoles,
partners,
also
utilized
macrocyclization
tactic
for
cyclic
peptide
synthesis
other
areas.
Язык: Английский
Iodine-mediated thio-arylation under electrochemical conditions
RSC Advances,
Год журнала:
2025,
Номер
15(15), С. 12042 - 12046
Опубликована: Янв. 1, 2025
An
efficient
iodine-mediated
electrochemical
construction
of
C–S
bonds
under
metal-free
and
chemical
oxidant-free
conditions.
Язык: Английский
Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ1–42 aggregation inhibition in Alzheimer's disease
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Sulfenylated
amino
pyrazoles:
inhibitors
of
acetylcholinesterase
and
butyrylcholinesterase.
Язык: Английский
Sodium Iodide-Promoted Construction of Fully Substituted 4-Sulfenyl-5-aminopyrazole Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
Transition-metal-free
synthesis
of
diversely
substituted
4-sulfenyl-5-aminopyrazoles
was
developed
under
mild
conditions
through
NaI-mediated
three-component
reaction
β-ketonitriles,
disulfides,
and
hydrazines.
The
pyrazole
products
were
constructed
via
consecutive
cleavage
C-O
S-S
bonds
recombination
C-N
C-S
bonds.
methodology
features
broad
substrate
scope,
transition-metal-free
conditions,
easy
manipulation.
Язык: Английский
tert‐Butyl Nitrite‐Mediated Deaminative Chalcogenation of Substituted 5‐Aminopyrazoles via Diaryl Dichalcogenides
Farman Moh Abbasi,
Aritra Ghosh,
Ruchir Kant
и другие.
ChemistrySelect,
Год журнала:
2025,
Номер
10(21)
Опубликована: Май 31, 2025
Abstract
An
expedited
route
to
the
synthesis
of
substituted
5‐(arylselanyl)‐1
H
‐pyrazoles
and
5‐(arylthio)‐1
via
reaction
between
5‐amino‐1
bearing
an
electron
withdrawing
group
(EWG)
at
C‐4
diaryl
dichalcogenides
in
presence
tert
‐butyl
nitrite
is
described.
The
protocol
compatible
with
substrates
different
EWGs,
such
as
carboxylate,
nitrile
or
phenylsulfonyl.
strategy
works
even
‐1,2,3‐triazoles
furnish
corresponding
chalcogenides.
mechanism
postulated
involve
a
radical
pathway.
Язык: Английский