tert‐Butyl Nitrite‐Mediated Deaminative Chalcogenation of Substituted 5‐Aminopyrazoles via Diaryl Dichalcogenides DOI

Farman Moh Abbasi,

Aritra Ghosh,

Ruchir Kant

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(21)

Published: May 31, 2025

Abstract An expedited route to the synthesis of substituted 5‐(arylselanyl)‐1 H ‐pyrazoles and 5‐(arylthio)‐1 via reaction between 5‐amino‐1 bearing an electron withdrawing group (EWG) at C‐4 diaryl dichalcogenides in presence tert ‐butyl nitrite is described. The protocol compatible with substrates different EWGs, such as carboxylate, nitrile or phenylsulfonyl. strategy works even ‐1,2,3‐triazoles furnish corresponding chalcogenides. mechanism postulated involve a radical pathway.

Language: Английский

Electro-induced C-H/S-H Cross-Coupling for the Functionalization/Macrocyclization of Cysteine-Containing Peptides DOI
Meng Gao,

Fang Xiang,

Jia Deng

et al.

Published: April 7, 2025

Abstract The electrochemical platform that underpins the promising future of selective modifications peptides and proteins, however, is still rather underdeveloped. Here in, an electro-induced umpolung approach enables efficient functionalization/macrocyclization cysteine-containing reported. Notably, this method utilizes simple halogen source takes metal-mediated atom transfer as main pathway to enable in-situ polarity reversal, highlighting unique possibilities associated with activation methods. Under mild conditions, cysteine residue can be well-labelled high chemo-selectivity excellent conversion. This transformation tolerate a wide range valuable enamines, azoles, partners, also utilized macrocyclization tactic for cyclic peptide synthesis other areas.

Language: Английский

Citations

0
Iodine-mediated thio-arylation under electrochemical conditions DOI Creative Commons
Jiajia Yu,

Tong Li,

Qi Sun

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(15), P. 12042 - 12046

Published: Jan. 1, 2025

An efficient iodine-mediated electrochemical construction of C–S bonds under metal-free and chemical oxidant-free conditions.

Language: Английский

Citations

0
Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ1–42 aggregation inhibition in Alzheimer's disease DOI
Payal Rani, Sandhya Chahal,

Anju Ranolia

et al.

RSC Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Sulfenylated amino pyrazoles: inhibitors of acetylcholinesterase and butyrylcholinesterase.

Language: Английский

Citations

0
Sodium Iodide-Promoted Construction of Fully Substituted 4-Sulfenyl-5-aminopyrazole Derivatives DOI
Zhongming Huang, Hao Wu,

Meiqi Geng

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Transition-metal-free synthesis of diversely substituted 4-sulfenyl-5-aminopyrazoles was developed under mild conditions through NaI-mediated three-component reaction β-ketonitriles, disulfides, and hydrazines. The pyrazole products were constructed via consecutive cleavage C-O S-S bonds recombination C-N C-S bonds. methodology features broad substrate scope, transition-metal-free conditions, easy manipulation.

Language: Английский

Citations

0
tert‐Butyl Nitrite‐Mediated Deaminative Chalcogenation of Substituted 5‐Aminopyrazoles via Diaryl Dichalcogenides DOI

Farman Moh Abbasi,

Aritra Ghosh,

Ruchir Kant

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(21)

Published: May 31, 2025

Abstract An expedited route to the synthesis of substituted 5‐(arylselanyl)‐1 H ‐pyrazoles and 5‐(arylthio)‐1 via reaction between 5‐amino‐1 bearing an electron withdrawing group (EWG) at C‐4 diaryl dichalcogenides in presence tert ‐butyl nitrite is described. The protocol compatible with substrates different EWGs, such as carboxylate, nitrile or phenylsulfonyl. strategy works even ‐1,2,3‐triazoles furnish corresponding chalcogenides. mechanism postulated involve a radical pathway.

Language: Английский

Citations

0