Pd-Catalyzed Domino Heck Cyclization/Cross-coupling of Indoles with β-Chlorovinyl Ketones: Synthesis of Antifungal Active Furan-bearing Indolo[2,1-α]isoquinolines
Yongqi Bai,
Xingrui Qi,
Hanjing Li
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
reaction
enabling
the
rapid
construction
of
three
bonds
to
form
furan-bearing
indolo[2,1-
α
]isoquinolines,
which
exhibit
certain
antifungal
activity
in
vitro
,
is
presented.
Язык: Английский
Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs
Feifei Jin,
Qing Wu,
Shuaijie Wu
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
A
novel
and
highly
efficient
Pd-catalyzed
approach
for
the
synthesis
of
bis-heterocycles
featuring
both
isoxazoline
methyleneindole
motifs
is
demonstrated.
The
in
situ
formation
vinyl
Pd(II)
species
through
an
alkyne-tethered
carbamoyl
chloride
cyclization
crucial,
innovative
carboetherification
β,γ-unsaturated
oximes
with
has
been
developed.
This
method
not
only
operationally
straightforward
but
also
exhibits
a
broad
substrate
scope
excellent
functional
group
tolerance.
Язык: Английский