Pd-Catalyzed Domino Heck Cyclization/Cross-coupling of Indoles with β-Chlorovinyl Ketones: Synthesis of Antifungal Active Furan-bearing Indolo[2,1-α]isoquinolines
Yongqi Bai,
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Xingrui Qi,
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Hanjing Li
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et al.
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
reaction
enabling
the
rapid
construction
of
three
bonds
to
form
furan-bearing
indolo[2,1-
α
]isoquinolines,
which
exhibit
certain
antifungal
activity
in
vitro
,
is
presented.
Language: Английский
Palladium-Catalyzed Domino Carboetherification Reactions: Synthesis of Bis-Heterocycles Bearing Isoxazoline and Methyleneindole Motifs
Feifei Jin,
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Qing Wu,
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Shuaijie Wu
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et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
A
novel
and
highly
efficient
Pd-catalyzed
approach
for
the
synthesis
of
bis-heterocycles
featuring
both
isoxazoline
methyleneindole
motifs
is
demonstrated.
The
in
situ
formation
vinyl
Pd(II)
species
through
an
alkyne-tethered
carbamoyl
chloride
cyclization
crucial,
innovative
carboetherification
β,γ-unsaturated
oximes
with
has
been
developed.
This
method
not
only
operationally
straightforward
but
also
exhibits
a
broad
substrate
scope
excellent
functional
group
tolerance.
Language: Английский