The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Herein,
we
report
a
sustainable
and
efficient
method
for
the
synthesis
of
structurally
diverse
phthalimidines
from
2-formylbenzoic
acid
primary
amines
using
an
iridium-catalyzed
reductive
lactamization
strategy.
The
advantages
this
method,
such
as
use
water–ethanol
solvent,
broad
substrate
scope,
high
catalyst
efficiency
(S/C
up
to
10000),
good
scalability,
easy
purification,
enable
it
be
practical
approach
phthalimidines.
It
is
suggested
that
iridium
hydride
formation
involved
in
rate-limiting
step.
Synthetic
applications
late-stage
functionalization
medicinally
relevant
molecules
are
also
demonstrated.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
In
this
study,
a
novel
approach
that
combines
photoinduced
electron
transfer
(ET)
with
hydrogen
atom
(HAT)
has
been
introduced
for
the
selective
β-C(sp3)–H
pyridination
of
carbonyl
compounds.
This
method
is
notable
its
absence
transition
metals
and
ability
to
function
under
benign
reaction
conditions,
resulting
in
range
pyridinated
derivatives
consistently
moderate
good
yields.
The
significance
technique
further
underscored
by
potential
late-stage
functionalization
pharmaceutically
significant
molecules.
Mechanistic
investigations
confirmed
proceeds
via
radical-mediated
pathway.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Herein,
the
first
example
of
self-catalyzed
sono-photoinduced
carbon-carbon
bond
formation
was
described.
Combining
advantages
phototriggered
self-catalysis
and
ultrasonic
catalysis,
a
wide
range
3-arylquinoxalin-2(1
A
100%
atom
economical
construction
of
hydroxyalkylated
N-heteroarenes
through
decatungstate-catalyzed
tandem
cyclization/self-hydrogenation
isocyanides
and
aldehydes
under
exogenous
hydrogen
reagent-
byproduct-free
conditions
was
developed.
Organic Chemistry Frontiers,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
study
reports
a
photocatalytic
nitrene
transfer
reaction
of
1,3-dicarbonyl.
A
broad
range
substrates
and
iodinanes
are
shown,
enabling
direct
C–H
functionalization
without
the
need
for
pre-formed
nucleophilic
enolate
equivalents.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
The
first
example
of
heterogeneous
photoredox-catalyzed
fluoroalkylation
4H-pyrido[1,2-a]pyrimidin-4-ones
has
been
developed.
With
low-cost
commercial
g-C3N4
as
the
recyclable
photocatalyst
and
cheap
sodium
fluoroalkyl
sulfonates
source,
a
variety
fluoroalkylated
pyridopyrimidinones
were
constructed
in
moderate
to
high
yields.
present
reaction
can
be
easily
scaled
up
with
good
efficiency,
catalytic
system
reused
5
times
slight
loss
activities.
Furthermore,
biological
activity
synthesized
compounds
was
preliminarily
investigated.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(6)
Опубликована: Май 19, 2025
ABSTRACT
AgOTf‐catalysed
regioselective
C1‐amination
of
pyrrolo[1,2‐
a
]quinoxaline
has
been
developed.
The
reaction
allowed
the
use
various
]quinoxalines
and
azodicarboxylates
as
coupling
partners
to
afford
C1‐aminated
products
with
good
excellent
yields.
synthetic
strategy
showed
regioselectivity,
functional
group
tolerance
well
gram‐scale
synthesis.
amination
were
further
modified
furnish
structurally
diverse
compounds.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 29, 2025
An
additive-free
approach
has
been
developed
for
the
synthesis
of
allylic
phosphorodithioates
through
tandem
phosphorodithiolation/rearrangement
alcohols
with
P4S10
and
alcohols.
The
reaction
proceeds
under
mild
conditions
provides
a
practical
protocol
to
prepare
series
in
moderate
good
yields.
