Photoredox-Catalyzed Regioselective 1,3-Alkoxypyridylation of gem-Difluorocyclopropanes DOI
Jiaxuan Shen, Meijun Chen, Xiangwei Du

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Difluoromethylene and pyridine cores are very important structural units in medicinal chemistry. Herein, we report the development of photoredox-catalyzed ring-opening 1,3-alkoxypyridylation gem-difluorinated cyclopropanes using 4-cyanopyrines alcohols, employing cyclopropane radical cations as key intermediate. The reaction exhibits high regioselectivity under mild conditions can also be practiced on gram-scale synthesis, telescoped reaction, late-stage functionalization biological molecules.

Язык: Английский

Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines DOI
Ao-Long Li,

R.-Q. Xie,

Quan Zhou

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A photochemical radical cascade cyclization reaction of isocyanides with α-carbonyl bromides under mild conditions is disclosed for accessing 1,4-dibenzodiazepines, demonstrating good tolerance towards various functional groups.

Язык: Английский

Процитировано

0
Photoredox-Catalyzed Regioselective 1,3-Alkoxypyridylation of gem-Difluorocyclopropanes DOI
Jiaxuan Shen, Meijun Chen, Xiangwei Du

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Difluoromethylene and pyridine cores are very important structural units in medicinal chemistry. Herein, we report the development of photoredox-catalyzed ring-opening 1,3-alkoxypyridylation gem-difluorinated cyclopropanes using 4-cyanopyrines alcohols, employing cyclopropane radical cations as key intermediate. The reaction exhibits high regioselectivity under mild conditions can also be practiced on gram-scale synthesis, telescoped reaction, late-stage functionalization biological molecules.

Язык: Английский

Процитировано

1