Photocatalytic Synthesis of Isoquinolinediones via the Cascade Reaction of N-Alkyl-N-methylacrylamides with Diazo Compounds DOI

Chenyue Zhao,

Heran Yang, Kai Xu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Carbon radicals generated from acceptor diazo compounds prefer to add electron-rich olefins and heteroarenes due their containing electron-withdrawing groups. Herein, a cascade reaction of with electron-deficient is developed. In the presence visible light Ru catalyst, generate carbon via proton-coupled electron transfer process, followed by addition various N-alkyl-N-methylacrylamides subsequent cyclization give series acyl-substituted isoquinolinediones.

Язык: Английский

Synthesis of α-SF5 Ketones by Oxypentafluorosulfanylation of Alkynes with SF5Cl and Oxygen DOI
Xinqiang Tan,

Yuezhen Li,

Ziyou Hao

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Herein for the first time, we disclose a practical and straightforward approach to access α-SF5 ketones via direct oxypentafluorosulfanylation of alkynes with SF5Cl oxygen under acidic conditions by one step. The protocol features mild reaction conditions, broad substrate scope, good functional group compatibility can be applied late-state functionalization complex natural products pharmaceuticals. A radical mechanism involving SF5 addition triple bonds followed O2 capture is proposed.

Язык: Английский

Процитировано

0
Substrate-Controlled Pentafluorosulfanylation of Activated Alkenes Containing the Benzimidazole Moiety with SF5Cl DOI
Xinqiang Tan,

Yuezhen Li,

Shijie Liu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

We report herein a method of substrate-controlled pentafluorosulfanylation activated alkenes containing the benzimidazole moiety with SF5Cl, which provides highly efficient way to access SF5-containing benzo[4,5]imidazole[2,1-a]isoquinolin-6(5H)-ones, as well N-benzoyl benzimidazoles. Besides pentafluorosulfanyl group (-SF5), current can be applied tetrafluorosulfanyl (-SF4-) incorporation. A radical mechanism involving single electron transfer (SET) or atom addition (ATRA) process is proposed.

Язык: Английский

Процитировано

0
Photocatalytic Synthesis of Isoquinolinediones via the Cascade Reaction of N-Alkyl-N-methylacrylamides with Diazo Compounds DOI

Chenyue Zhao,

Heran Yang, Kai Xu

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Carbon radicals generated from acceptor diazo compounds prefer to add electron-rich olefins and heteroarenes due their containing electron-withdrawing groups. Herein, a cascade reaction of with electron-deficient is developed. In the presence visible light Ru catalyst, generate carbon via proton-coupled electron transfer process, followed by addition various N-alkyl-N-methylacrylamides subsequent cyclization give series acyl-substituted isoquinolinediones.

Язык: Английский

Процитировано

0