The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: June 2, 2025
Herein, we present a B/Cu-catalyzed asymmetric Mannich reaction, utilizing β,γ-alkynyl-α-ketimino esters and ortho-hydroxy aryl ketones. The reaction initiates with the activation of ketones via borinic acid to form tetracoordinated enol boronate complex, followed by chiral Cu complex-assisted an electrophilic ketimino ester. also works alkyl-chained ketones, producing adducts moderate good diastereoselectivity. practical applicability is evidenced gram-scale subsequent elaboration adduct.
Language: Английский