ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4804 - 4814
Опубликована: Июнь 27, 2024
Protein
cages
are
promising
tools
for
the
controlled
delivery
of
therapeutics
and
imaging
agents
when
endowed
with
programmable
disassembly
strategies.
Here,
we
produced
hybrid
nanocomposites
made
tobacco
mosaic
virus
(TMV)
magnetic
iron
oxide
nanoparticles
(IONPs),
designed
to
disrupt
viral
protein
using
magnetically
induced
release
heat.
We
studied
effects
this
hyperthermia
on
capsid
(1)
elongated
TMV
coated
heterogeneously
(TMV@IONPs)
(2)
spherical
polystyrene
(PS)
which
deposited
presynthesized
IONPs
via
layer-by-layer
self-assembly
(PS@IONPs/TMV).
Notably,
found
that
extent
is
contingent
upon
specific
absorption
rate
(SAR)
nanoparticles,
is,
heating
efficiency,
relative
position
cage
within
nanocomposite
concerning
sources.
This
implies
spatial
arrangement
components
nanostructure
has
a
significant
impact
process.
Understanding
optimizing
relationship
will
contribute
critical
spatiotemporal
control
targeted
drug
gene
cages.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 931 - 931
Опубликована: Март 13, 2023
Cancer
is
a
multifaceted
disease
that
results
from
the
complex
interaction
between
genetic
and
environmental
factors.
mortal
with
biggest
clinical,
societal,
economic
burden.
Research
on
better
methods
of
detection,
diagnosis,
treatment
cancer
crucial.
Recent
advancements
in
material
science
have
led
to
development
metal–organic
frameworks,
also
known
as
MOFs.
MOFs
recently
been
established
promising
adaptable
delivery
platforms
target
vehicles
for
therapy.
These
constructed
fashion
offers
them
capability
drug
release
stimuli-responsive.
This
feature
has
potential
be
exploited
therapy
externally
led.
review
presents
an
in-depth
summary
research
conducted
date
field
MOF-based
nanoplatforms
therapeutics.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
The
pioneering
work
on
liposomes
in
the
1960s
and
subsequent
research
controlled
drug
release
systems
significantly
advances
development
of
nanocarriers
(NCs)
for
delivery.
This
field
is
evolved
to
include
a
diverse
array
such
as
liposomes,
polymeric
nanoparticles,
dendrimers,
more,
each
tailored
specific
therapeutic
applications.
Despite
significant
achievements,
clinical
translation
limited,
primarily
due
low
efficiency
delivery
an
incomplete
understanding
nanocarrier
interactions
with
biological
systems.
Addressing
these
challenges
requires
interdisciplinary
collaboration
deep
nano‐bio
interface.
To
enhance
design,
scientists
employ
both
physics‐based
data‐driven
models.
Physics‐based
models
provide
detailed
insights
into
chemical
reactions
at
atomic
molecular
scales,
while
leverage
machine
learning
analyze
large
datasets
uncover
hidden
mechanisms.
integration
presents
harmonizing
different
modeling
approaches
ensuring
model
validation
generalization
across
However,
this
crucial
developing
effective
targeted
By
integrating
enhanced
data
infrastructure,
explainable
AI,
computational
advances,
potentials,
researchers
can
develop
innovative
nanomedicine
solutions,
ultimately
improving
outcomes.
Gels,
Год журнала:
2023,
Номер
9(10), С. 833 - 833
Опубликована: Окт. 20, 2023
In
this
review,
we
focused
on
recent
efforts
in
the
design
and
development
of
materials
with
biomimetic
properties.
Innovative
methods
promise
to
emulate
cell
microenvironments
tissue
functions,
but
many
aspects
regarding
cellular
communication,
motility,
responsiveness
remain
be
explained.
We
photographed
state-of-the-art
advancements
biomimetics,
discussed
complexity
a
“bottom-up”
artificial
construction
living
systems,
particular
highlights
hydrogels,
collagen-based
composites,
surface
modifications,
three-dimensional
(3D)
bioprinting
applications.
Fast-paced
3D
printing
intelligence,
nevertheless,
collide
reality:
How
difficult
can
it
build
reproducible
at
real
scale
line
systems?
Nowadays,
science
is
urgent
need
bioengineering
technologies
for
practical
use
bioinspired
biomimetics
medicine
clinics.
Abstract
Corneal
neovascularization
(CoNV)
is
a
major
cause
of
visual
impairment
worldwide.
Currently,
available
treatment
options
have
limited
efficacy
and
are
associated
with
adverse
effects
due
to
biological
barriers
clearance
mechanisms.
To
address
this
challenge,
novel
topical
delivery
system
developed—Gel
2_1&Eylea
—an
aflibercept‐loaded
eye‐drop
hydrogel
mediated
cell‐penetrating
peptide
1
.
Gel
demonstrates
superior
membrane
permeability,
increased
stability,
prolonged
drug
retention
time
on
the
ocular
surface,
thus
may
improve
efficacy.
In
rabbit
CoNV
model,
significantly
reduces
density
no
normal
corneoscleral
limbal
vessels,
demonstrating
high
biocompatibility.
This
work
identifies
promising
for
which
has
potential
benefit
other
neovascular
diseases.
Materials,
Год журнала:
2023,
Номер
16(24), С. 7550 - 7550
Опубликована: Дек. 7, 2023
"Green"
strategies
to
build
up
novel
organic
nanocarriers
with
bioperformance
are
modern
trends
in
nanotechnology.
In
this
way,
the
valorization
of
bio-wastes
and
use
living
systems
develop
multifunctional
biogenic
(OBNs)
have
revolutionized
nanotechnological
biomedical
fields.
This
paper
is
a
comprehensive
review
related
OBNs
for
bioactives'
delivery,
providing
an
overview
reports
on
past
two
decades.
first
part,
several
classes
bioactive
compounds
their
therapeutic
role
briefly
presented.
A
broad
section
dedicated
main
categories
nanocarriers.
The
major
challenges
regarding
eco-design
fate
suggested
overcome
some
toxicity-related
drawbacks.
Future
directions
opportunities,
finding
"green"
solutions
solving
problems
nanocarriers,
outlined
final
paper.
We
believe
that
through
review,
we
will
capture
attention
readers
open
new
perspectives
solutions/ideas
discovery
more
efficient
ways
developing
bioperformant
transporting
agents.
