ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4804 - 4814
Опубликована: Июнь 27, 2024
Protein
cages
are
promising
tools
for
the
controlled
delivery
of
therapeutics
and
imaging
agents
when
endowed
with
programmable
disassembly
strategies.
Here,
we
produced
hybrid
nanocomposites
made
tobacco
mosaic
virus
(TMV)
magnetic
iron
oxide
nanoparticles
(IONPs),
designed
to
disrupt
viral
protein
using
magnetically
induced
release
heat.
We
studied
effects
this
hyperthermia
on
capsid
(1)
elongated
TMV
coated
heterogeneously
(TMV@IONPs)
(2)
spherical
polystyrene
(PS)
which
deposited
presynthesized
IONPs
via
layer-by-layer
self-assembly
(PS@IONPs/TMV).
Notably,
found
that
extent
is
contingent
upon
specific
absorption
rate
(SAR)
nanoparticles,
is,
heating
efficiency,
relative
position
cage
within
nanocomposite
concerning
sources.
This
implies
spatial
arrangement
components
nanostructure
has
a
significant
impact
process.
Understanding
optimizing
relationship
will
contribute
critical
spatiotemporal
control
targeted
drug
gene
cages.
Peptides
can
serve
as
building
blocks
for
supramolecular
materials
because
of
their
unique
ability
to
self-assemble,
offering
potential
applications
in
drug
delivery,
tissue
engineering,
and
nanotechnology.
In
this
review,
we
describe
peptide
self-assembly
a
sequence-
context-dependent
process
its
resulting
complexity
due
the
heterogeneity
sequences
experimental
conditions,
which
makes
cross-laboratory
reproducibility
serious
challenge
standardized
reporting
necessity.
Given
large
number
possible
permutations,
machine
learning
(ML)
is
suitable
navigating
search
space
with
aim
reducing
trial-and-error
experimentation
speeding
up
discovery
self-assembling
peptides.
However,
point
out
that
ML
not
point-and-shoot
tool
be
applied
directly
any
problem
requires
careful
consideration,
domain
knowledge,
proper
data
preparation
achieve
meaningful
results.
addition,
discuss
lack
negative
reported
main
limiting
factor
effective
application
ML.
Considering
transformative
artificial
intelligence,
conclude
grasping
power
language
models
generative
approaches,
coupled
explainability
techniques,
will
expedite
nanomaterials
discovery.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(5), С. 2841 - 2862
Опубликована: Апрель 22, 2024
Cancer
is
a
severe
threat
to
humans,
as
it
the
second
leading
cause
of
death
after
cardiovascular
diseases
and
still
poses
biggest
challenge
in
world
medicine.
Due
its
higher
mortality
rates
resistance,
requires
more
focused
productive
approach
provide
solution
for
it.
Many
therapies
promising
deliver
favorable
results,
such
chemotherapy
radiotherapy,
have
come
up
with
negatives
than
positives.
Therefore,
new
class
medicinal
solutions
targeted
essence.
This
review
highlights
alluring
properties,
configurations,
self-assembly
peptide
molecules
which
benefit
traditional
toward
cancer
therapy
while
sparing
healthy
cells
process.
As
drug
delivery
systems,
self-assembled
peptides
offer
wide
spectrum
conjugation,
biocompatibility,
degradability-controlled
responsiveness,
biomedical
applications,
including
treatment
imaging.
Bioinorganic Chemistry and Applications,
Год журнала:
2023,
Номер
2023, С. 1 - 15
Опубликована: Ноя. 13, 2023
Numerous
supramolecular
platforms
inspired
by
natural
self-assembly
are
exploited
as
drug
delivery
systems.
The
spontaneous
arrangement
of
single
building
blocks
into
inorganic
and
organic
structures
is
determined
controlled
noncovalent
forces
such
electrostatic
interactions,
π-π
hydrogen
bonds,
van
der
Waals
interactions.
This
review
describes
the
main
characteristics
several
used
to
obtain
stable,
self-assembling
nanostructures
tailored
for
numerous
biological
applications.
Owing
their
versatility,
biocompatibility,
controllability,
these
find
application
in
diverse
fields
ranging
from
drug/gene
delivery,
theranostics,
tissue
engineering,
nanoelectronics.
Herein,
we
described
different
approaches
design
functionalize
nanomaterials
selective
a
specific
disease.
In
particular,
highlights
efficiency
applications
related
infectious
diseases
cancer.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4804 - 4814
Опубликована: Июнь 27, 2024
Protein
cages
are
promising
tools
for
the
controlled
delivery
of
therapeutics
and
imaging
agents
when
endowed
with
programmable
disassembly
strategies.
Here,
we
produced
hybrid
nanocomposites
made
tobacco
mosaic
virus
(TMV)
magnetic
iron
oxide
nanoparticles
(IONPs),
designed
to
disrupt
viral
protein
using
magnetically
induced
release
heat.
We
studied
effects
this
hyperthermia
on
capsid
(1)
elongated
TMV
coated
heterogeneously
(TMV@IONPs)
(2)
spherical
polystyrene
(PS)
which
deposited
presynthesized
IONPs
via
layer-by-layer
self-assembly
(PS@IONPs/TMV).
Notably,
found
that
extent
is
contingent
upon
specific
absorption
rate
(SAR)
nanoparticles,
is,
heating
efficiency,
relative
position
cage
within
nanocomposite
concerning
sources.
This
implies
spatial
arrangement
components
nanostructure
has
a
significant
impact
process.
Understanding
optimizing
relationship
will
contribute
critical
spatiotemporal
control
targeted
drug
gene
cages.
