ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4804 - 4814
Published: June 27, 2024
Protein
cages
are
promising
tools
for
the
controlled
delivery
of
therapeutics
and
imaging
agents
when
endowed
with
programmable
disassembly
strategies.
Here,
we
produced
hybrid
nanocomposites
made
tobacco
mosaic
virus
(TMV)
magnetic
iron
oxide
nanoparticles
(IONPs),
designed
to
disrupt
viral
protein
using
magnetically
induced
release
heat.
We
studied
effects
this
hyperthermia
on
capsid
(1)
elongated
TMV
coated
heterogeneously
(TMV@IONPs)
(2)
spherical
polystyrene
(PS)
which
deposited
presynthesized
IONPs
via
layer-by-layer
self-assembly
(PS@IONPs/TMV).
Notably,
found
that
extent
is
contingent
upon
specific
absorption
rate
(SAR)
nanoparticles,
is,
heating
efficiency,
relative
position
cage
within
nanocomposite
concerning
sources.
This
implies
spatial
arrangement
components
nanostructure
has
a
significant
impact
process.
Understanding
optimizing
relationship
will
contribute
critical
spatiotemporal
control
targeted
drug
gene
cages.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
To
combat
the
emerging
threat
of
antimicrobial
resistance
(AMR),
in
this
study,
two
amphiphilic
nucleopeptides
(NPs)
were
synthesized
by
conjugating
nucleobase
thymine
with
peptide
amphiphiles.
These
compounds
fully
characterized
using
various
analytical
techniques.
Notably,
both
formed
hydrogels
milli-Q
water
at
neutral
pH
(pH
6.9).
X-ray
diffraction
further
confirmed
antiparallel
β-sheet-like
structures,
along
aromatic
π–π
stacking
and
hydrogen-bonding
(H-bonding)
interactions
between
moieties
gel
phase.
Field
emission
gun
transmission
electron
microscopy
revealed
a
nanofibrillar
network
structure
these
self-assembled
peptides.
A
significant
feature
supramolecular
self-assemblies
is
their
potent
activity
against
types
bacteria,
such
as
Gram-positive
Gram-negative
standard
American
Type
Culture
Collection
(ATCC)
including
Bacillus
subtilis,
Escherichia
coli,
multidrug-resistant
clinically
isolated
ATCC
strains
methicillin-resistant
Staphylococcus
aureus
(MRSA),
Klebsiella
pneumoniae,
Pseudomonas
aeruginosa.
Among
these,
peptides
demonstrated
remarkable
inhibition
MRSA
(MIC:
15.92–16.86
μM)
K.
pneumoniae
8.8–50
μM),
highlighting
potential
agents
deadly
(MDR)
bacteria.
Additionally,
assemblies
found
to
be
highly
biocompatible,
MTT
assays
on
HEK-293
cells,
showing
IC50
values
range
0.5–1.1
mM.
In
an
vitro
wound
healing
assay
HeLa
fluorescence
that
treatment
did
not
disrupt
cell
or
mitochondrial
membranes
cells.
This
work
presents
broad-spectrum
efficacy
MDR
demonstrates
high
biocompatibility,
supporting
use
agents.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 29, 2025
Peptides
can
serve
as
building
blocks
for
supramolecular
materials
because
of
their
unique
ability
to
self-assemble,
offering
potential
applications
in
drug
delivery,
tissue
engineering,
and
nanotechnology.
In
this
review,
we
describe
peptide
self-assembly
a
sequence-
context-dependent
process
its
resulting
complexity
due
the
heterogeneity
sequences
experimental
conditions,
which
makes
cross-laboratory
reproducibility
serious
challenge
standardized
reporting
necessity.
Given
large
number
possible
permutations,
machine
learning
(ML)
is
suitable
navigating
search
space
with
aim
reducing
trial-and-error
experimentation
speeding
up
discovery
self-assembling
peptides.
However,
point
out
that
ML
not
point-and-shoot
tool
be
applied
directly
any
problem
requires
careful
consideration,
domain
knowledge,
proper
data
preparation
achieve
meaningful
results.
addition,
discuss
lack
negative
reported
main
limiting
factor
effective
application
ML.
Considering
transformative
artificial
intelligence,
conclude
grasping
power
language
models
generative
approaches,
coupled
explainability
techniques,
will
expedite
nanomaterials
discovery.
Bioinorganic Chemistry and Applications,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 15
Published: Nov. 13, 2023
Numerous
supramolecular
platforms
inspired
by
natural
self-assembly
are
exploited
as
drug
delivery
systems.
The
spontaneous
arrangement
of
single
building
blocks
into
inorganic
and
organic
structures
is
determined
controlled
noncovalent
forces
such
electrostatic
interactions,
π-π
hydrogen
bonds,
van
der
Waals
interactions.
This
review
describes
the
main
characteristics
several
used
to
obtain
stable,
self-assembling
nanostructures
tailored
for
numerous
biological
applications.
Owing
their
versatility,
biocompatibility,
controllability,
these
find
application
in
diverse
fields
ranging
from
drug/gene
delivery,
theranostics,
tissue
engineering,
nanoelectronics.
Herein,
we
described
different
approaches
design
functionalize
nanomaterials
selective
a
specific
disease.
In
particular,
highlights
efficiency
applications
related
infectious
diseases
cancer.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4804 - 4814
Published: June 27, 2024
Protein
cages
are
promising
tools
for
the
controlled
delivery
of
therapeutics
and
imaging
agents
when
endowed
with
programmable
disassembly
strategies.
Here,
we
produced
hybrid
nanocomposites
made
tobacco
mosaic
virus
(TMV)
magnetic
iron
oxide
nanoparticles
(IONPs),
designed
to
disrupt
viral
protein
using
magnetically
induced
release
heat.
We
studied
effects
this
hyperthermia
on
capsid
(1)
elongated
TMV
coated
heterogeneously
(TMV@IONPs)
(2)
spherical
polystyrene
(PS)
which
deposited
presynthesized
IONPs
via
layer-by-layer
self-assembly
(PS@IONPs/TMV).
Notably,
found
that
extent
is
contingent
upon
specific
absorption
rate
(SAR)
nanoparticles,
is,
heating
efficiency,
relative
position
cage
within
nanocomposite
concerning
sources.
This
implies
spatial
arrangement
components
nanostructure
has
a
significant
impact
process.
Understanding
optimizing
relationship
will
contribute
critical
spatiotemporal
control
targeted
drug
gene
cages.
