Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Янв. 25, 2023

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient’s quality of life. A disrupted barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components AD pathogenesis. Patients exhibit decreased expression antimicrobial peptides (AMPs) which linked to by . The microbiome itself source several AMPs. These host- microbiome-derived AMPs define landscape based on their differential activity against range microbes or quorum sensing inhibitory properties. particularly important in preventing limiting dysbiotic In addition, for immune homeostasis. this article, we share our perspectives about implications derived patients potential effects overlapping factors involved AD. We argue discuss bacterial as therapeutics

Язык: Английский

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Recent developments in peptidomics for the quali-quantitative analysis of food-derived peptides in human body fluids and tissues

Trends in Food Science & Technology, Год журнала: 2022, Номер 126, С. 41 - 60

Опубликована: Июнь 28, 2022

Язык: Английский

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Mass spectrometry‐based proteomics approaches to interrogate skeletal muscle adaptations to exercise

Scandinavian Journal of Medicine and Science in Sports, Год журнала: 2023, Номер 34(1)

Опубликована: Март 27, 2023

Acute exercise and chronic training elicit beneficial whole‐body changes in physiology that ultimately depend on profound alterations to the dynamics of tissue‐specific proteins. Since work accomplished during owes predominantly skeletal muscle, it has received majority interest from scientists attempt unravel adaptive mechanisms accounting for salutary metabolic effects performance improvements arise training. Contemporary are also beginning use mass spectrometry‐based proteomics, which is emerging as a powerful approach interrogate muscle protein signature more comprehensive manner. Collectively, these technologies facilitate analysis several viewpoints, including intracellular proteins (expression proteomics), secreted (secretomics), post‐translational modifications well fiber‐, cell‐, organelle‐specific changes. This review aims highlight recent literature leveraged new workflows advances proteomics further our understanding training‐related muscle. We call attention untapped areas research relating metabolism, basic points contention when applying analyses, particularly study human biology. encourage researchers couple hypothesis‐generating descriptive nature omics data with functional analyses propel complex responses occur acute exercise.

Язык: Английский

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An omics review and perspective of researches on intrahepatic cholestasis of pregnancy

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Intrahepatic cholestasis of pregnancy (ICP) is one the common complications that may threaten health both pregnant women and their fetuses. Hence, it vital importance to identify key moleculars associated functional pathways ICP, which will help us better understand pathological mechanisms as well develop precise clinical biomarkers. The emerging developing multiple omics approaches enable comprehensive studies genome, transcriptome, proteome metabolome samples. present review collected summarized based aiming provide an overview current progress, limitations future directions. Briefly, these covered a broad range research contents by comparing different experimental groups including ICP patients, subtypes, fetuses, models other complications. Correspondingly, studied samples contain various types samples,

Язык: Английский

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Origins, Technological Advancement, and Applications of Peptidomics

Methods in molecular biology, Год журнала: 2024, Номер unknown, С. 3 - 47

Опубликована: Янв. 1, 2024

Язык: Английский

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Network analysis of the proteome and peptidome sheds light on human milk as a biological system

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 30, 2024

Abstract Proteins and peptides found in human milk have bioactive potential to benefit the newborn support healthy development. Research has been carried out on health benefits of proteins peptides, but many questions still need be answered about nature these components, how they are formed, end up milk. This study explored elucidated complexity proteome peptidome. were analyzed with non-targeted nanoLC-Orbitrap-MS/MS a selection 297 samples from CHILD Cohort Study. Protein peptide abundances determined, network was inferred using Gaussian graphical modeling (GGM), allowing an investigation direct associations. showed that signatures (1) specific mechanisms transport different groups proteins, (2) proteolytic degradation by proteases aminopeptidases, (3) coagulation complement activation present These results show value integrated approach evaluating large-scale omics data sets provide valuable information for studies aim associate protein or profiles biofluids such as physiological characteristics.

Язык: Английский

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Peptidomics as a tool to analyze endogenous peptides in milk and milk-related peptides

Food Bioscience, Год журнала: 2022, Номер 50, С. 102199 - 102199

Опубликована: Ноя. 13, 2022

Язык: Английский

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Plant Sample Preparation for Metabolomics, Lipidomics, Ionomics, Fluxomics, and Peptidomics

Separations, Год журнала: 2025, Номер 12(2), С. 21 - 21

Опубликована: Янв. 24, 2025

Plant metabolomics, lipidomics, ionomics, fluxomics, and peptidomics are essential approaches for exploring how plants respond to epigenetic, pathological, environmental stimuli through comprehensive chemical profiling. Over the past decades, significant progress has been made in protocols methodologies address challenges sample collection extraction. Despite these advancements, preparation remains intricate, with ongoing debates about most effective strategies. This review emphasizes importance of clear research questions well-designed experiments minimize complexity, save time, enhance reproducibility. It provides an overview key steps fields, including harvesting, drying, extraction, data pre-acquisition major analytical platforms. By discussing best practices common challenges, this aims streamline methods promote more consistent reliable outcomes.

Язык: Английский

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Peptidomic Differences Between Natural Musk and Secretions from Forest Musk Gland Cells Cultured In Vitro

Pharmacognosy Magazine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

Background The Chinese forest musk deer, a solitary ungulate renowned for its secretion, is under extinction threat despite extensive use in traditional medicine and perfumery. demand significantly outstrips natural supply. Purpose This study aimed to explore the differences peptide profiles between cultured gland cells develop sustainable alternatives production aid conservation of deer. Materials Methods Musk samples from deer were collected analyzed using EASY-nLC 1000 system. Peptide extraction, nano LC–MS/MS analysis, advanced peptidomics techniques employed identify compare compositions. Results found significant secreted Cultured could partially replicate complex environment musk, with some unique peptides identified not present secretions. Conclusion While show potential mimicking synthesis, notable suggest importance gland’s microenvironment deer’s physiological conditions. research establishes foundation optimizing culture enhance therapeutic qualities synthesized contributing species.

Язык: Английский

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Impact of intestinal components on muscle quality deterioration in red shrimp (Solenocera crassicornis) during cold storage

Food Chemistry, Год журнала: 2025, Номер 477, С. 143571 - 143571

Опубликована: Фев. 25, 2025

Язык: Английский

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