Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2022, Номер 44, С. 102581 - 102581
Опубликована: Июль 8, 2022
Язык: Английский
Chinese Chemical Letters, Год журнала: 2022, Номер 34(2), С. 107518 - 107518
Опубликована: Май 14, 2022
Язык: Английский
Процитировано
358
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 258, С. 115612 - 115612
Опубликована: Июль 5, 2023
Язык: Английский
Процитировано
54
Advanced Functional Materials, Год журнала: 2024, Номер 34(19)
Опубликована: Янв. 4, 2024
Abstract The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent that regulates the transport various materials substances between blood vasculature central nervous (CNS). However, in cases brain diseases, BBB's protective regulatory effects hamper therapeutics from reaching affected sites sufficient quantities. This has so far been leading challenge treating CNS diseases disorders. For this problem to be overcome, recent research sought develop novel modalities achieve efficient therapy alleviate associated symptoms. Therefore, numerous strategies have operated years address limitations traditional invasive methods, including poor penetration serious side effects. As desperately in‐demand technology, nanotheranostics particularly shown promising results. Herein, review reports advancements techniques nanotechnology‐based developed for neurodegenerative study provides comprehensive data on subject used future studies management disorders diseases.
Язык: Английский
Процитировано
26
Advanced Science, Год журнала: 2022, Номер 9(16)
Опубликована: Март 31, 2022
Abstract The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by contribution bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding and invasion BBB endothelial cells in meningitis, utilization ability EC‐K1 for brain‐targeted drug delivery construction a biomimetic self‐assembled nanoparticle with surface featuring lipopolysaccharide‐free are proposed. penetration nanoparticles is demonstrated occur through transcellular vesicle transport pathway, which at least partially dependent on internalization, endosomal escape, transcytosis mediated interactions between protein A gp96 cells. This nanoengineering strategy endows loaded drugs prolonged circulation, interstitial distribution, extremely high biocompatibility. Based critical roles cancer biology, this reveals enormous potential delivering therapeutics treat gp96‐overexpressing malignancies.
Язык: Английский
Процитировано
53
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 125993 - 125993
Опубликована: Июль 27, 2023
Язык: Английский
Процитировано
32
Accounts of Chemical Research, Год журнала: 2023, Номер 56(12), С. 1578 - 1590
Опубликована: Май 23, 2023
ConspectusTheranostic nanoparticles' potential in tumor treatment has been widely acknowledged thanks to their capability of integrating multifaceted functionalities into a single nanosystem. Theranostic nanoparticles are typically equipped with an inorganic core exploitable physical properties for imaging and therapeutic functions, bioinert coatings improved biocompatibility immunological stealth, controlled drug-loading–release modules, the ability recognize specific cell type uptake. Integrating multiple nanosized construct require sophisticated molecular design precise execution assembly procedures. Underlying multifunctionality theranostic nanoparticles, ligand chemistry plays decisive role translating theoretical designs fully functionalized nanoparticles. The hierarchy is usually threefold. As they serve passivate nanoparticle's surface, capping ligands form first layer directly interfacing crystalline lattice core. size shape largely determined by property so that have profound influences on surface properties. Capping mostly chemically inert, which necessitates presence additional drug loading targeting. second commonly utilized loading. Therapeutic drugs can either be covalently conjugated onto or noncovalently loaded via drug-loading ligands. Drug-loading need equally versatile accommodate diversity drugs. Biodegradable moieties often incorporated enable smart release. With aid targeting stand tallest nanoparticle seek bind corresponding receptors target, preferentially accumulate at site attain higher precision quantity delivery. In this Account, utilities representative ligands, reviewed. Since these types assembled close vicinity each other, it essential them compatible able function tandem other. Relevant conjugation strategies critical factors significant impact ligands' performance discussed. Representative presented showcase how different synergistically from Finally, technological outlook evolving provided.
Язык: Английский
Процитировано
30
Aging and Disease, Год журнала: 2024, Номер 15(1), С. 169 - 169
Опубликована: Янв. 1, 2024
Brain metastases and related complications are one of the major fatal factors in cancer. Patients with breast cancer, lung melanoma at a high risk developing brain metastases. However, mechanisms underlying metastatic cascade remain poorly understood. Microglia, resident macrophages parenchyma, involved multiple processes associated metastasis, including inflammation, angiogenesis, immune modulation. They also closely interact cancer cells, astrocytes, other cells. Current therapeutic approaches against cancers, small-molecule drugs, antibody-coupled drugs (ADCs), immune-checkpoint inhibitors (ICIs), have compromised efficacy owing to impermeability blood-brain barrier (BBB) complex microenvironment. Targeting microglia is strategies for treating In this review, we summarize multifaceted roles highlight them as potential targets future interventions.
Язык: Английский
Процитировано
18
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142486 - 142486
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2021, Номер 13(12), С. 2024 - 2024
Опубликована: Ноя. 27, 2021
The blood-brain barrier (BBB) precisely controls brain microenvironment and neural activity by regulating substance transport into out of the brain. However, it severely hinders drug entry brain, efficiency various systemic therapies against diseases. Modulation BBB via opening tight junctions, inhibiting active efflux and/or enhancing transcytosis, possesses potential to increase permeability improve intracranial concentrations therapeutic efficiency. Various strategies modulation have been reported investigated preclinically clinically. This review describes conventional emerging related mechanisms, safety issues according structures functions, try give more promising directions for designing reasonable preclinical clinical studies.
Язык: Английский
Процитировано
43
Pharmaceutics, Год журнала: 2022, Номер 14(10), С. 2092 - 2092
Опубликована: Сен. 30, 2022
Cancer cells normally develop the ability to rewire or reprogram themselves become resistant treatments that were previously effective. Despite progress in understanding drug resistance, knowledge gaps remain regarding underlying biological causes of resistance and design cancer overcome it. So, acquisition remains a major problem treatment. Targeted therapeutics are considered next generation therapy because they many limitations traditional treatments. Numerous tumor overexpress several receptors have high binding affinity for hyaluronic acid (HA), while poorly expressed normal body cells. HA its derivatives advantage being biocompatible biodegradable may be conjugated with variety drugs carriers developing various formulations as anticancer therapies such micelles, nanogels, inorganic nanoparticles. Due their stability blood circulation predictable delivery patterns, enhanced tumor-selective accumulation, decreased toxicity tissues, tumor-targeting nanomaterial-based systems been shown represent an efficacious approach treatment cancer. In this review, we aim provide overview some vitro vivo studies related potential ligand targeted nanovehicles future biomedical applications
Язык: Английский
Процитировано
33