Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 833 - 847
Published: Dec. 16, 2023
Language: Английский
Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518
Published: May 14, 2022
Language: Английский
Citations
350
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 258, P. 115612 - 115612
Published: July 5, 2023
Language: Английский
Citations
52
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)
Published: Jan. 4, 2024
Abstract The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent that regulates the transport various materials substances between blood vasculature central nervous (CNS). However, in cases brain diseases, BBB's protective regulatory effects hamper therapeutics from reaching affected sites sufficient quantities. This has so far been leading challenge treating CNS diseases disorders. For this problem to be overcome, recent research sought develop novel modalities achieve efficient therapy alleviate associated symptoms. Therefore, numerous strategies have operated years address limitations traditional invasive methods, including poor penetration serious side effects. As desperately in‐demand technology, nanotheranostics particularly shown promising results. Herein, review reports advancements techniques nanotechnology‐based developed for neurodegenerative study provides comprehensive data on subject used future studies management disorders diseases.
Language: Английский
Citations
26
Aging and Disease, Journal Year: 2024, Volume and Issue: 15(1), P. 169 - 169
Published: Jan. 1, 2024
Brain metastases and related complications are one of the major fatal factors in cancer. Patients with breast cancer, lung melanoma at a high risk developing brain metastases. However, mechanisms underlying metastatic cascade remain poorly understood. Microglia, resident macrophages parenchyma, involved multiple processes associated metastasis, including inflammation, angiogenesis, immune modulation. They also closely interact cancer cells, astrocytes, other cells. Current therapeutic approaches against cancers, small-molecule drugs, antibody-coupled drugs (ADCs), immune-checkpoint inhibitors (ICIs), have compromised efficacy owing to impermeability blood-brain barrier (BBB) complex microenvironment. Targeting microglia is strategies for treating In this review, we summarize multifaceted roles highlight them as potential targets future interventions.
Language: Английский
Citations
18
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142486 - 142486
Published: March 1, 2025
Language: Английский
Citations
2
Advanced Science, Journal Year: 2022, Volume and Issue: 9(16)
Published: March 31, 2022
Abstract The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by contribution bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding and invasion BBB endothelial cells in meningitis, utilization ability EC‐K1 for brain‐targeted drug delivery construction a biomimetic self‐assembled nanoparticle with surface featuring lipopolysaccharide‐free are proposed. penetration nanoparticles is demonstrated occur through transcellular vesicle transport pathway, which at least partially dependent on internalization, endosomal escape, transcytosis mediated interactions between protein A gp96 cells. This nanoengineering strategy endows loaded drugs prolonged circulation, interstitial distribution, extremely high biocompatibility. Based critical roles cancer biology, this reveals enormous potential delivering therapeutics treat gp96‐overexpressing malignancies.
Language: Английский
Citations
53
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 125993 - 125993
Published: July 27, 2023
Language: Английский
Citations
31
Accounts of Chemical Research, Journal Year: 2023, Volume and Issue: 56(12), P. 1578 - 1590
Published: May 23, 2023
ConspectusTheranostic nanoparticles' potential in tumor treatment has been widely acknowledged thanks to their capability of integrating multifaceted functionalities into a single nanosystem. Theranostic nanoparticles are typically equipped with an inorganic core exploitable physical properties for imaging and therapeutic functions, bioinert coatings improved biocompatibility immunological stealth, controlled drug-loading–release modules, the ability recognize specific cell type uptake. Integrating multiple nanosized construct require sophisticated molecular design precise execution assembly procedures. Underlying multifunctionality theranostic nanoparticles, ligand chemistry plays decisive role translating theoretical designs fully functionalized nanoparticles. The hierarchy is usually threefold. As they serve passivate nanoparticle's surface, capping ligands form first layer directly interfacing crystalline lattice core. size shape largely determined by property so that have profound influences on surface properties. Capping mostly chemically inert, which necessitates presence additional drug loading targeting. second commonly utilized loading. Therapeutic drugs can either be covalently conjugated onto or noncovalently loaded via drug-loading ligands. Drug-loading need equally versatile accommodate diversity drugs. Biodegradable moieties often incorporated enable smart release. With aid targeting stand tallest nanoparticle seek bind corresponding receptors target, preferentially accumulate at site attain higher precision quantity delivery. In this Account, utilities representative ligands, reviewed. Since these types assembled close vicinity each other, it essential them compatible able function tandem other. Relevant conjugation strategies critical factors significant impact ligands' performance discussed. Representative presented showcase how different synergistically from Finally, technological outlook evolving provided.
Language: Английский
Citations
29
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(12), P. 2024 - 2024
Published: Nov. 27, 2021
The blood-brain barrier (BBB) precisely controls brain microenvironment and neural activity by regulating substance transport into out of the brain. However, it severely hinders drug entry brain, efficiency various systemic therapies against diseases. Modulation BBB via opening tight junctions, inhibiting active efflux and/or enhancing transcytosis, possesses potential to increase permeability improve intracranial concentrations therapeutic efficiency. Various strategies modulation have been reported investigated preclinically clinically. This review describes conventional emerging related mechanisms, safety issues according structures functions, try give more promising directions for designing reasonable preclinical clinical studies.
Language: Английский
Citations
42
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(10), P. 2092 - 2092
Published: Sept. 30, 2022
Cancer cells normally develop the ability to rewire or reprogram themselves become resistant treatments that were previously effective. Despite progress in understanding drug resistance, knowledge gaps remain regarding underlying biological causes of resistance and design cancer overcome it. So, acquisition remains a major problem treatment. Targeted therapeutics are considered next generation therapy because they many limitations traditional treatments. Numerous tumor overexpress several receptors have high binding affinity for hyaluronic acid (HA), while poorly expressed normal body cells. HA its derivatives advantage being biocompatible biodegradable may be conjugated with variety drugs carriers developing various formulations as anticancer therapies such micelles, nanogels, inorganic nanoparticles. Due their stability blood circulation predictable delivery patterns, enhanced tumor-selective accumulation, decreased toxicity tissues, tumor-targeting nanomaterial-based systems been shown represent an efficacious approach treatment cancer. In this review, we aim provide overview some vitro vivo studies related potential ligand targeted nanovehicles future biomedical applications
Language: Английский
Citations
32