Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery DOI Creative Commons
Min Young Jeong,

Doe Myung Shin,

Min Kyeong Kwon

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(22), С. 1781 - 1781

Опубликована: Ноя. 5, 2024

The aim of the study is to formulate an injectable nanocrystalline suspension (NS) dutasteride (DTS), a hydrophobic 5α-reductase inhibitor used treat benign prostatic hyperplasia and scalp hair loss, for parenteral long-acting delivery. A DTS-loaded NS (DTS-NS, 40 mg/mL DTS) was prepared using lab-scale bead-milling technique. optimized DTS-NS Tween 80 (0.5%

Язык: Английский

The dynamic process of mRNA delivery by lipid nanoparticles in vivo DOI

Runpu Ma,

Yuting Li, Yi Wei

и другие.

Nano Today, Год журнала: 2024, Номер 57, С. 102325 - 102325

Опубликована: Май 30, 2024

Язык: Английский

Процитировано

12
Targeting Strategies for Site-Specific mRNA Delivery DOI
Jiaxing Di, Pei Huang, Xiaoyuan Chen

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер 35(4), С. 453 - 456

Опубликована: Март 16, 2024

mRNA therapeutics hold great promise for disease treatment, yet a key challenge lies in achieving site-specific delivery to maximize therapeutic efficacy while minimizing off-target side effects. This viewpoint delves into multiple complementary targeting strategies achieve precise delivery, covering topics of administration routes, passive targeting, and active targeting. It highlights the critical importance rationally designed nanocarriers obtaining desired effects accelerating clinical translation therapeutics.

Язык: Английский

Процитировано

9
Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches DOI Creative Commons
Wei Wang,

Shiwei Deng,

Jinzhong Lin

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(10), С. 4591 - 4607

Опубликована: Июль 18, 2024

The lipid nanoparticle (LNP) has been so far proven as a strongly effective delivery system for mRNA and siRNA. However, the mechanisms of LNP's distribution, metabolism, elimination are complicated, while transportation pharmacokinetics (PK) LNP just sparsely investigated simply described. This study aimed to build model RNA-LNP in Hela cells, rats, mice, humans by physiologically based pharmacokinetic (PBPK) quantum mechanics (QM) models with integrated multi-source data. LNPs different ionizable lipids, particle sizes, doses were modeled compared recognizing their critical parameters dominating PK. Some interesting results found models. For example, metabolism lipids was first limited disassembly rate instead hydrolyzation lipids; ability RNA release from endosomes three quantitively derived can predict probability release. Moreover, biodegradability estimated QM method is generally consistent result PBPK result. In summary, among various species time successfully constructed. Various

Язык: Английский

Процитировано

4
Characterization of mRNA-LNP structural features and mechanisms for enhanced mRNA vaccine immunogenicity DOI

Kangzeng Wu,

Fengwei Xu,

Yongchao Dai

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 1288 - 1299

Опубликована: Ноя. 13, 2024

Язык: Английский

Процитировано

3
Leveraging Model Master Files for Long-Acting Injectables DOI Creative Commons
Yuqing Gong,

Robert Hopefl,

Tonglei Li

и другие.

Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract The U.S. Food and Drug Administration (FDA) the Center for Research on Complex Generics (CRCG) hosted a public workshop May 2–3, 2024, titled “Considerations Potential Regulatory Applications Model Master File (Lachaine et al Can J Psychiatry. 60:S40-S47, 2015)”. aimed to discuss application of (MMF) concept in regulatory submissions that contain model integrated evidence (MIE), improving sharing, standardization, consistency, efficiency. On Day 1, there was session dedicated MMF applications long-acting injectables (LAIs). This perspective summarizes presentations, panel discussion, small group discussion potential MMFs LAI product development, including case studies situations which can support submissions. scientific presentations discussed mechanistic physiologically based pharmacokinetic (PBPK), multiphysics simulation, population pharmacokinetics (popPK) models, as well utility model-integrated bioequivalence (MI-BE) framework. Additionally, challenges considerations implementing LAIs were groups. anticipated benefits are recognized among developers, industries, regulators. Graphical

Язык: Английский

Процитировано

0
PBPK Modeling: Empowering Drug Development and Precision Dosing in China DOI Creative Commons
Dongsheng Yang, Jian Li, Wen Yao Mak

и другие.

CPT Pharmacometrics & Systems Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and precision dosing, simulates disposition in the human body by integrating physiological, biochemical, physicochemical parameters. While PBPK modeling has advanced globally since 1970s, China's adoption this technology followed distinctive path, characterized accelerated growth over past 2 decades. This review provides comprehensive analysis contributions to addressing knowledge gaps publication trends, application domains, platform preferences. A systematic literature search yielded 266 original research articles from PubMed up August 08, 2024. The revealed that drug–drug interaction studies constitute largest proportion analyses China. Chinese universities hospitals emerge as leading contributors among institutions Although established commercial such GastroPlus Simcyp remain popular within pharmaceutical industry, open‐source platforms like PK‐Sim are gaining significant traction applications across underscores transformative potential China, offering valuable insights into future directions challenges field.

Язык: Английский

Процитировано

0
Fabrication of a Spiral Microfluidic Chip for the Mass Production of Lipid Nanoparticles Using Laser Engraving DOI Creative Commons

Inseong Choi,

Mincheol Cho,

Min Song

и другие.

Micromachines, Год журнала: 2025, Номер 16(5), С. 501 - 501

Опубликована: Апрель 25, 2025

A spiral microfluidic chip (SMC) and multi-spiral (MSMC) for lipid nanoparticle (LNP) production were fabricated using a CO2 laser engraving method, perfluoropolyether (PFPE) poly(ethylene glycol) diacrylate as photopolymerizable base materials. The SMC includes microchannel that enables rapid fluid mixing, thereby facilitating the of small uniform LNPs with size 72.82 ± 24.14 nm PDI 0.111 0.011. MSMC integrates multiple parallel structures, which high-throughput LNP without compromising quality achieves maximum capacity 960 mL per hour. fabrication technology has potential applications in pharmaceutical field due to ease fabrication, simplicity cost-effectiveness process, ability produce high-quality LNPs.

Язык: Английский

Процитировано

0
Revealing the Dynamic Process of Mrna Delivery by Lipid Nanoparticles in Vivo DOI

Runpu Ma,

Yuting Li, Yi Wei

и другие.

Опубликована: Янв. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Язык: Английский

Процитировано

0
Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery DOI Creative Commons
Min Young Jeong,

Doe Myung Shin,

Min Kyeong Kwon

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(22), С. 1781 - 1781

Опубликована: Ноя. 5, 2024

The aim of the study is to formulate an injectable nanocrystalline suspension (NS) dutasteride (DTS), a hydrophobic 5α-reductase inhibitor used treat benign prostatic hyperplasia and scalp hair loss, for parenteral long-acting delivery. A DTS-loaded NS (DTS-NS, 40 mg/mL DTS) was prepared using lab-scale bead-milling technique. optimized DTS-NS Tween 80 (0.5%

Язык: Английский

Процитировано

0