Comment on “Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights” DOI
David Kessel

Molecular Pharmaceutics, Год журнала: 2024, Номер 22(1), С. 583 - 584

Опубликована: Дек. 5, 2024

InfoMetrics Molecular PharmaceuticsASAPArticle CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse CommunicationDecember 5, 2024Comment on "Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends Insights"Click to copy article linkArticle link copied!David Kessel*David KesselDepartment of Pharmacology, Wayne State University School Medicine, Detroit, Michigan 48201, United States*Email: [email protected]More by David Kesselhttps://orcid.org/0000-0002-3221-9299Other Access OptionsMolecular PharmaceuticsCite this: Mol. Pharmaceutics 2024, XXXX, XXX, XXX-XXXClick citationCitation copied!https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c00385https://doi.org/10.1021/acs.molpharmaceut.4c00385Published December 2024 Publication History Received 9 April 2024Accepted 3 2024Revised 21 October 2024Published online 5 2024rapid-communication© American Chemical SocietyRequest reuse permissionsACS Publications© Society Subjectswhat are subjectsArticle subjects automatically applied from the ACS Subject Taxonomy describe scientific concepts themes article.AssaysFree radicalsMitochondriaPeptides proteinsPhotosensitization Note: In lieu an abstract, this is article's first page. Read To access article, please review available below. Get instant Purchase 48 hours. Check out below using your ID or as a guest. Restore my guest Recommended through Your Institution You may have institution. institution does not content. Add change let them know you'd like include access. Through Recommend Name Loading Institutional Login Options... Change Explore subscriptions institutions Log in with if you previously purchased it member benefits. hours $48.00 cart Checkout Cited By Click section linkSection copied!This has yet been cited other publications.Download PDF e-AlertsGet e-AlertsMolecular copied!https://doi.org/10.1021/acs.molpharmaceut.4c00385Published 2024© permissionsArticle Views-Altmetric-Citations-Learn about these metrics closeArticle Views COUNTER-compliant sum full text downloads since November 2008 (both HTML) across all individuals. These regularly updated reflect usage leading up last few days.Citations number articles citing calculated Crossref daily. Find more information counts.The Altmetric Attention Score quantitative measure attention that research received online. Clicking donut icon will load page at altmetric.com additional details score social media presence given article. how calculated.Recommended Articles

Язык: Английский

Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors DOI

Diego Abad-Montero,

Albert Gandioso, Eduardo Izquierdo‐García

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7360 - 7376

Опубликована: Фев. 15, 2025

Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands derived from COUPY coumarins, termed COUBPYs. Ru-COUBPY exhibit outstanding in vitro cytotoxicity against CT-26 cells when irradiated light within phototherapeutic window, achieving nanomolar potency both normoxic hypoxic conditions while remaining nontoxic dark, impressive phototoxic indices (>30,000). Their ability generate Type I II ROS underpins their exceptional PDT efficiency. The lead compound study, SCV49, shows favorable vivo pharmacokinetic profile, excellent toxicological tolerability, tumor growth inhibition mice bearing subcutaneous tumors at doses as low 3 mg/kg upon deep-red (660 nm). These results allow us propose SCV49 strong candidate for further preclinical development, particularly treating large tumors.

Язык: Английский

Процитировано

2

Mitochondria-Targeted Photothermal-Chemodynamic Therapy Enhances Checkpoint Blockade Immunotherapy on Colon Cancer DOI Creative Commons

Benchao Zheng,

Hongbo Wang,

Shiyi Zhai

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101542 - 101542

Опубликована: Фев. 4, 2025

Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. This effect been attributed several studies release damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed multifunctional nanoplatform enables photothermal-chemodynamic combination conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). Upon near-infrared (NIR) irradiation, AIT ablates cells amplifies chemodynamic (CDT), thereby inducing apoptosis tumor. The CDT promotes immunogenic cell death, could checkpoint blockade In bilateral mouse colon model, observed complete eradication light-irradiated primary tumors significant inhibition distant untreated group treated plus anti-PD-1 (αPD-1). found increase serum levels pro-inflammatory factors, including interleukin-6 (IL-6), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), following PTT/CDT/immunotherapy treatment, suggesting effective activation response. enhanced immunogenicity caused αPD-1 treatment resulted efficient antigen presentation, indicated increased infiltration dendritic (DCs) into tumor-draining lymph nodes (LNs). CD8+ T compared alone. Hence, mitochondria-targeting represents an strategy potentiate photothermal, chemodynamic, therapies metastatic cancer.

Язык: Английский

Процитировано

1

Mitochondrial signaling pathways and their role in cancer drug resistance DOI
Ashwani Sharma, Tarun Virmani, Girish Kumar

и другие.

Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329

Опубликована: Авг. 5, 2024

Язык: Английский

Процитировано

9

Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer DOI Creative Commons
Danrong Hu, Yicong Li, Ran Li

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5106 - 5131

Опубликована: Ноя. 2, 2024

Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.

Язык: Английский

Процитировано

7

Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy DOI
G. Attar,

M. Kumar,

Vandana Bhalla

и другие.

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Язык: Английский

Процитировано

5

Applications and challenges of photodynamic therapy in the treatment of skin malignancies DOI Creative Commons

Yunqi Hua,

Xiaoling Tian,

Xinyi Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 19, 2024

Photodynamic Therapy (PDT), as a minimally invasive treatment method, has demonstrated its distinct advantages in the management of skin malignant tumors. This article examines current application status PDT, assesses successful cases and challenges clinical treatment, anticipates future development trends. PDT utilizes photosensitizers to interact with light specific wavelengths generate reactive oxygen species that selectively eradicate cancer cells. Despite PDT’s exceptional performance enhancing patients’ quality life prognosis, limitation depth side effects remain unresolved issues. With advancement novel innovative technology, prospects are increasingly expansive. delves into mechanism various malignancies, limitations, envisions development. We believe through continuous technological enhancements integration other technologies, potential assume more pivotal role malignancies.

Язык: Английский

Процитировано

5

Revolutionizing rheumatoid arthritis treatment with emerging cutaneous drug delivery systems: overcoming the challenges and paving the way forward DOI Creative Commons
Sakshi Priya,

Kaushal Kamal Jain,

Jeevika Daryani

и другие.

Nanoscale, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Overview of the ongoing trends in targeting strategies drugs via topical and transdermal delivery futuristic approaches world drug for management rheumatoid arthritis. Images are created with Biorender.com.

Язык: Английский

Процитировано

5

Win-win integration: A mitochondria targeted AIE photosensitizer for hypochlorite detection and type I & type II photodynamic therapy DOI

Jiahao Ni,

L.H. Yu, Yixuan Wang

и другие.

Analytica Chimica Acta, Год журнала: 2024, Номер 1320, С. 343035 - 343035

Опубликована: Июль 28, 2024

Язык: Английский

Процитировано

4

Acid-activatable photosensitizers for photodynamic therapy using self-aggregates of chlorophyll‒peptide conjugates DOI Creative Commons

Miyu Nagatani,

Masaru Yoshikawa, Shinya Tsukiji

и другие.

Polymer Journal, Год журнала: 2024, Номер 57(1), С. 119 - 128

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

4

Regulated cell death mechanisms in mitochondria-targeted phototherapy DOI
Qihang Ding, Hyeonji Rha,

Changyu Yoon

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113720 - 113720

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0