Chemical Papers, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7360 - 7376
Опубликована: Фев. 15, 2025
Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands derived from COUPY coumarins, termed COUBPYs. Ru-COUBPY exhibit outstanding in vitro cytotoxicity against CT-26 cells when irradiated light within phototherapeutic window, achieving nanomolar potency both normoxic hypoxic conditions while remaining nontoxic dark, impressive phototoxic indices (>30,000). Their ability generate Type I II ROS underpins their exceptional PDT efficiency. The lead compound study, SCV49, shows favorable vivo pharmacokinetic profile, excellent toxicological tolerability, tumor growth inhibition mice bearing subcutaneous tumors at doses as low 3 mg/kg upon deep-red (660 nm). These results allow us propose SCV49 strong candidate for further preclinical development, particularly treating large tumors.
Язык: Английский
Процитировано
2
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
9
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5106 - 5131
Опубликована: Ноя. 2, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) have garnered significant attention in cancer research because of their potential for precise spatiotemporal release tailored to high ROS levels within tumors. Despite the challenges posed by distribution heterogeneity and endogenous supply constraints, this review highlights strategic alliance ROS-responsive DDSs with photodynamic therapy (PDT), enabling selective leveraging PDT-induced enhanced therapeutic efficacy. This delves into biological importance progression treatment. We elucidate detail operational mechanisms linkers, including thioether, thioketal, selenide, diselencide, telluride aryl boronic acids/esters, as well latest developments nanomedicines that integrate PDT strategies. These insights are intended inspire design innovative nanocarriers PDT.
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 19, 2024
Photodynamic Therapy (PDT), as a minimally invasive treatment method, has demonstrated its distinct advantages in the management of skin malignant tumors. This article examines current application status PDT, assesses successful cases and challenges clinical treatment, anticipates future development trends. PDT utilizes photosensitizers to interact with light specific wavelengths generate reactive oxygen species that selectively eradicate cancer cells. Despite PDT’s exceptional performance enhancing patients’ quality life prognosis, limitation depth side effects remain unresolved issues. With advancement novel innovative technology, prospects are increasingly expansive. delves into mechanism various malignancies, limitations, envisions development. We believe through continuous technological enhancements integration other technologies, potential assume more pivotal role malignancies.
Язык: Английский
Процитировано
7
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101542 - 101542
Опубликована: Фев. 4, 2025
Immunotherapy has emerged as a hotspot for cancer treatment. However, the response rate of monotherapy remains relatively low in clinical settings. Photothermal therapy (PTT), which employs light energy to ablate tumors, can also activate tumor-specific immune responses. This effect been attributed several studies release damage-associated molecular patterns (DAMPs) triggered by mitochondrial injury. We propose that mitochondria-targeted PTT may better synergize with immunotherapy. Herein, we constructed multifunctional nanoplatform enables photothermal-chemodynamic combination conjugating indocyanine green-thiol (ICG-SH) and mercaptoethyl-triphenylphosphonium (TPP-SH) onto polyvinyl pyrrolidone (PVP)-coated gold-copper nanoparticles (AIT). Upon near-infrared (NIR) irradiation, AIT ablates cells amplifies chemodynamic (CDT), thereby inducing apoptosis tumor. The CDT promotes immunogenic cell death, could checkpoint blockade In bilateral mouse colon model, observed complete eradication light-irradiated primary tumors significant inhibition distant untreated group treated plus anti-PD-1 (αPD-1). found increase serum levels pro-inflammatory factors, including interleukin-6 (IL-6), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), following PTT/CDT/immunotherapy treatment, suggesting effective activation response. enhanced immunogenicity caused αPD-1 treatment resulted efficient antigen presentation, indicated increased infiltration dendritic (DCs) into tumor-draining lymph nodes (LNs). CD8+ T compared alone. Hence, mitochondria-targeting represents an strategy potentiate photothermal, chemodynamic, therapies metastatic cancer.
Язык: Английский
Процитировано
1
Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.
Язык: Английский
Процитировано
5
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Overview of the ongoing trends in targeting strategies drugs via topical and transdermal delivery futuristic approaches world drug for management rheumatoid arthritis. Images are created with Biorender.com.
Язык: Английский
Процитировано
5
Analytica Chimica Acta, Год журнала: 2024, Номер 1320, С. 343035 - 343035
Опубликована: Июль 28, 2024
Язык: Английский
Процитировано
4
Polymer Journal, Год журнала: 2024, Номер 57(1), С. 119 - 128
Опубликована: Сен. 19, 2024
Язык: Английский
Процитировано
4
The Journal of Physical Chemistry Letters, Год журнала: 2024, Номер 15(43), С. 10866 - 10872
Опубликована: Окт. 23, 2024
Most of the traditional fluorescent molecules have advantages high fluorescence quantum yield, good stability, and excellent structural adjustability, but they exhibit characteristics quenching caused by aggregation, which restricts their application in aqueous solutions or solids. The luminescence properties photosensitive potential aggregation-induced emission (AIE) materials a condensed state made them widely concerned scientific research field, so it is very challenging to regulate transformation aggregation-caused (ACQ) fluorophores into AIE fluorophores. In this study, coumarin fluorophore was used as matrix. After conjugating triphenylamine group, triphenylphosphine cation linked through alkyl chain obtain molecular probe NCTPP with characteristic, water solubility, mitochondrial green light imaging, chemotherapy photodynamic therapy capabilities. As far we know, first time that photosensitivity imparted ACQ-AIE conversion method.
Язык: Английский
Процитировано
3