Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(9), С. 7360 - 7376
Опубликована: Фев. 15, 2025
Hypoxia,
a
hallmark
of
many
solid
tumors,
is
linked
to
increased
cancer
aggressiveness,
metastasis,
and
resistance
conventional
therapies,
leading
poor
patient
outcomes.
This
challenges
the
efficiency
photodynamic
therapy
(PDT),
which
relies
on
generation
cytotoxic
reactive
oxygen
species
(ROS)
through
irradiation
photosensitizer
(PS),
process
partially
dependent
levels.
In
this
work,
we
introduce
novel
family
potent
PSs
based
ruthenium(II)
polypyridyl
complexes
with
2,2′-bipyridyl
ligands
derived
from
COUPY
coumarins,
termed
COUBPYs.
Ru-COUBPY
exhibit
outstanding
in
vitro
cytotoxicity
against
CT-26
cells
when
irradiated
light
within
phototherapeutic
window,
achieving
nanomolar
potency
both
normoxic
hypoxic
conditions
while
remaining
nontoxic
dark,
impressive
phototoxic
indices
(>30,000).
Their
ability
generate
Type
I
II
ROS
underpins
their
exceptional
PDT
efficiency.
The
lead
compound
study,
SCV49,
shows
favorable
vivo
pharmacokinetic
profile,
excellent
toxicological
tolerability,
tumor
growth
inhibition
mice
bearing
subcutaneous
tumors
at
doses
as
low
3
mg/kg
upon
deep-red
(660
nm).
These
results
allow
us
propose
SCV49
strong
candidate
for
further
preclinical
development,
particularly
treating
large
tumors.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101542 - 101542
Опубликована: Фев. 4, 2025
Immunotherapy
has
emerged
as
a
hotspot
for
cancer
treatment.
However,
the
response
rate
of
monotherapy
remains
relatively
low
in
clinical
settings.
Photothermal
therapy
(PTT),
which
employs
light
energy
to
ablate
tumors,
can
also
activate
tumor-specific
immune
responses.
This
effect
been
attributed
several
studies
release
damage-associated
molecular
patterns
(DAMPs)
triggered
by
mitochondrial
injury.
We
propose
that
mitochondria-targeted
PTT
may
better
synergize
with
immunotherapy.
Herein,
we
constructed
multifunctional
nanoplatform
enables
photothermal-chemodynamic
combination
conjugating
indocyanine
green-thiol
(ICG-SH)
and
mercaptoethyl-triphenylphosphonium
(TPP-SH)
onto
polyvinyl
pyrrolidone
(PVP)-coated
gold-copper
nanoparticles
(AIT).
Upon
near-infrared
(NIR)
irradiation,
AIT
ablates
cells
amplifies
chemodynamic
(CDT),
thereby
inducing
apoptosis
tumor.
The
CDT
promotes
immunogenic
cell
death,
could
checkpoint
blockade
In
bilateral
mouse
colon
model,
observed
complete
eradication
light-irradiated
primary
tumors
significant
inhibition
distant
untreated
group
treated
plus
anti-PD-1
(αPD-1).
found
increase
serum
levels
pro-inflammatory
factors,
including
interleukin-6
(IL-6),
interferon-γ
(IFN-γ),
tumor
necrosis
factor-α
(TNF-α),
following
PTT/CDT/immunotherapy
treatment,
suggesting
effective
activation
response.
enhanced
immunogenicity
caused
αPD-1
treatment
resulted
efficient
antigen
presentation,
indicated
increased
infiltration
dendritic
(DCs)
into
tumor-draining
lymph
nodes
(LNs).
CD8+
T
compared
alone.
Hence,
mitochondria-targeting
represents
an
strategy
potentiate
photothermal,
chemodynamic,
therapies
metastatic
cancer.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(12), С. 5106 - 5131
Опубликована: Ноя. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Among
various
cancer
treatment
methods,
photodynamic
therapy
has
received
significant
attention
due
to
its
non-invasiveness
and
high
efficiency
in
inhibiting
tumour
growth.
Recently,
specific
organelle
targeting
photosensitizers
have
increasing
interest
their
precise
accumulation
ability
trigger
organelle-mediated
cell
death
signalling
pathways,
which
greatly
reduces
the
drug
dosage,
minimizes
toxicity,
avoids
multidrug
resistance,
prevents
recurrence.
In
this
review,
recent
advances
representative
used
targeted
on
organelles,
specifically
including
endoplasmic
reticulum,
Golgi
apparatus,
mitochondria,
nucleus,
lysosomes,
been
comprehensively
reviewed
with
a
focus
structure
pathways.
Furthermore,
perspective
future
research
potential
challenges
precision
presented
at
end.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 19, 2024
Photodynamic
Therapy
(PDT),
as
a
minimally
invasive
treatment
method,
has
demonstrated
its
distinct
advantages
in
the
management
of
skin
malignant
tumors.
This
article
examines
current
application
status
PDT,
assesses
successful
cases
and
challenges
clinical
treatment,
anticipates
future
development
trends.
PDT
utilizes
photosensitizers
to
interact
with
light
specific
wavelengths
generate
reactive
oxygen
species
that
selectively
eradicate
cancer
cells.
Despite
PDT’s
exceptional
performance
enhancing
patients’
quality
life
prognosis,
limitation
depth
side
effects
remain
unresolved
issues.
With
advancement
novel
innovative
technology,
prospects
are
increasingly
expansive.
delves
into
mechanism
various
malignancies,
limitations,
envisions
development.
We
believe
through
continuous
technological
enhancements
integration
other
technologies,
potential
assume
more
pivotal
role
malignancies.
Overview
of
the
ongoing
trends
in
targeting
strategies
drugs
via
topical
and
transdermal
delivery
futuristic
approaches
world
drug
for
management
rheumatoid
arthritis.
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are
created
with
Biorender.com.
