Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 22, 2023
Hydrogels
are
widely
used
biomaterials
in
the
delivery
of
therapeutic
agents,
including
drugs,
genes,
proteins,
etc.,
as
well
tissue
engineering,
due
to
obvious
properties
such
biocompatibility
and
their
similarity
natural
body
tissues.
Some
these
substances
have
feature
injectability,
which
means
that
substance
is
injected
into
desired
place
solution
state
then
turns
gel,
makes
it
possible
administer
them
from
a
way
with
minimal
amount
invasion
eliminate
need
for
surgery
implant
pre-formed
materials.
Gelation
can
be
caused
by
stimulus
and/or
spontaneously.
Suppose
this
induces
effect
one
or
many
stimuli.
In
case,
material
question
called
stimuli-responsive
because
responds
surrounding
conditions.
context,
we
introduce
different
stimuli
cause
gelation
investigate
mechanisms
transformation
gel
them.
Also,
study
special
structures,
nano
gels
nanocomposite
gels.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Май 24, 2023
Abstract
Breathing
is
an
inherent
human
activity;
however,
the
composition
of
air
we
inhale
and
gas
exhale
remains
unknown
to
us.
To
address
this,
wearable
vapor
sensors
can
help
people
monitor
in
real
time
avoid
underlying
risks,
for
early
detection
treatment
diseases
home
healthcare.
Hydrogels
with
three-dimensional
polymer
networks
large
amounts
water
molecules
are
naturally
flexible
stretchable.
Functionalized
hydrogels
intrinsically
conductive,
self-healing,
self-adhesive,
biocompatible,
room-temperature
sensitive.
Compared
traditional
rigid
sensors,
hydrogel-based
humidity
directly
fit
skin
or
clothing,
more
suitable
real-time
monitoring
personal
health
safety.
In
this
review,
current
studies
on
investigated.
The
required
properties
optimization
methods
introduced.
Subsequently,
existing
reports
response
mechanisms
summarized.
Related
works
their
application
safety
presented.
Moreover,
potential
field
sensing
elucidated.
Finally,
research
status,
challenges,
future
trends
hydrogel
gas/humidity
discussed.
Molecules,
Год журнала:
2021,
Номер
26(6), С. 1593 - 1593
Опубликована: Март 13, 2021
Nowadays,
sustainable
materials
are
receiving
significant
attention
due
to
the
fact
that
they
will
be
crucial
for
development
of
next
generation
products
and
devices.
In
present
work,
hydrogels
have
been
successfully
synthesized
using
lignin
which
is
non-valorized
biopolymer
from
paper
industry.
Hydrogels
were
prepared
via
crosslinking
with
Poly(ethylene)
glycol
diglycidyl
ether
(PEGDGE).
Different
crosslinker
ratios
used
determine
their
influence
on
structural
chemical
properties
resulting
hydrogels.
It
has
found
pore
size
was
reduced
by
increasing
amount.
The
greater
density
increased
swelling
capacity
presence
more
hydrophilic
groups
in
hydrogel
network.
Paracetamol
release
test
showed
higher
drug
diffusion
produced
a
ratio
lignin:PEGDGE
1:1.
obtained
results
demonstrate
proposed
approach
promising
route
utilize
lignocellulose
waste
producing
porous
advanced
biomedical
applications
pharmacy
International Journal of Oral Science,
Год журнала:
2021,
Номер
13(1)
Опубликована: Март 16, 2021
Issues
caused
by
maxillofacial
tumours
involve
not
only
dealing
with
but
also
repairing
jaw
bone
defects.
In
traditional
tumour
therapy,
the
systemic
toxicity
of
chemotherapeutic
drugs,
invasive
surgical
resection,
intractable
recurrence,
and
metastasis
are
major
threats
to
patients'
lives
in
clinic.
Fortunately,
biomaterial-based
intervention
can
improve
efficiency
treatment
decrease
possibility
recurrence
metastasis,
suggesting
new
promising
antitumour
therapies.
addition,
tissue
defects
their
negatively
affect
physiological
psychological
health
patients,
investment
result
a
multitude
burdens
society.
Biomaterials
options
because
they
have
good
biocompatibility
bioactive
properties
for
stimulation
regeneration.
More
interestingly,
an
integrated
material
regimen
that
combines
therapy
repair
is
option.
Herein,
we
summarized
biomaterial-mediated
treatments
analysed
biomaterials
defect
repair.
Furthermore,
proposed
superior
design
dual-functional
simultaneous
regeneration
provide
strategy
managing
quality
life
patients
future.
Advanced Materials,
Год журнала:
2021,
Номер
34(1)
Опубликована: Окт. 23, 2021
Methods
capable
of
distributing
antitumor
therapeutics
uniformly
and
durably
throughout
an
entire
tumor
would
be
great
significance
in
maximizing
their
treatment
efficacy,
but
they
have
proven
to
extremely
challenging.
Here,
bacteria-mediated
spatiotemporally
controllable
distribution
combination
solid
tumors
is
reported
reprogram
the
immune
microenvironment
for
optimizing
efficacy.
By
combining
synthetic
biology
interfacial
chemistry,
bacteria
are
inside
outside
concurrently
modified
express
photothermal
melanin
attach
checkpoint
inhibitors
on
surface.
Due
nature
colonize
hypoxia
intratumoral
environment,
both
therapeutic
agents
can
distributed
homogenously
lastingly
during
ex
vivo
human
mouse
studies.
Spatiotemporally
localization
repeatedly
generate
a
moderate
yet
uniform
heating
upon
light
exposure
broad
window.
Combination
with
similarly
localized
elicits
dual
photothermally
stimulated
checkpoint-blockade-mediated
activation
effect,
synergistically
reprogramming
immunosuppressive
microenvironment.
Therapeutic
values
demonstrated
by
significantly
inhibited
growth
prolonged
survival
mice
subcutaneous
orthotopic
murine
models.
Colonization
dually
paves
avenue
drugs
tumors.
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
194, С. 114724 - 114724
Опубликована: Фев. 4, 2023
The
use
of
systemic
anticancer
chemotherapy
is
intrinsically
limited
by
its
toxicity.
Whether
dealing
with
small
molecules
or
biopharmaceuticals,
after
administration,
doses
fail
to
reach
effective
intratumoral
concentrations,
while
high
significant
tumor
inhibition
effects
may
also
drive
the
death
healthy
cells,
endangering
patients.
Therefore,
strategies
based
on
drug
delivery
systems
(DDSs)
for
avoiding
toxicity
have
been
designed.
Due
their
ability
protect
drugs
from
early
elimination
and
control
release,
DDSs
can
foster
exposure
therapeutics
extending
circulation
time
steadily
releasing
into
sites.
However,
approval
tailored
clinical
minimal
as
safety
in
vivo
activity
still
need
be
ameliorated
manipulating
physicochemical
characteristics.
During
last
few
years,
several
described
improve
safety,
stability,
fine-tune
pharmaceuticals
release
kinetics.
Herein,
we
reviewed
main
DDSs,
namely
polymeric
conjugates,
nano
microparticles,
hydrogels,
microneedles,
explored
long-acting
treatments,
highlighting
recently
proposed
modifications
potential
advantages
different
therapies.
Additionally,
important
limitations
therapies
future
technology
directions
were
covered.
Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
7(3)
Опубликована: Апрель 2, 2022
Nanomaterials'
unique
structures
at
the
nanometer
level
determine
their
incredible
functions,
and
based
on
this,
they
can
be
widely
used
in
field
of
nanomedicine.
However,
nanomaterials
do
possess
disadvantages
that
cannot
ignored,
such
as
burst
release,
rapid
elimination,
poor
bioadhesion.
Hydrogels
are
scaffolds
with
three-dimensional
structures,
exhibit
good
biocompatibility
drug
release
capacity.
also
associated
for
biomedical
applications
anti-tumor
capability,
weak
bioimaging
limited
responsiveness,
so
on.
Incorporating
into
3D
hydrogel
network
through
physical
or
chemical
covalent
action
may
an
effective
method
to
avoid
disadvantages.
In
nanocomposite
systems,
multifunctional
often
work
function
core,
giving
hydrogels
a
variety
properties
(such
photo-thermal
conversion,
magnetothermal
conductivity,
targeting
tumor,
etc.).
While,
effectively
improve
retention
effect
make
nanoparticles
have
plasticity
adapt
various
biosensors).
Nanocomposite
systems
broad
application
prospects
biomedicine.
this
review,
we
comprehensively
summarize
discuss
most
recent
advances
composite
biomedicine,
including
cell
delivery,
cancer
treatment,
tissue
regeneration,
biosensing,
bioimaging,
briefly
discussed
current
situation
commoditization
