Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Efficient
and
site-specific
delivery
of
therapeutics
drugs
remains
a
critical
challenge
in
cancer
treatment.
Traditional
drug
nanocarriers
such
as
antibody-drug
conjugates
are
not
generally
accessible
due
to
their
high
cost
can
lead
serious
side
effects
including
life-threatening
allergic
reactions.
Here,
these
problems
overcome
via
the
engineering
supramolecular
agents
that
manufactured
with
an
innovative
double
imprinting
approach.
The
developed
molecularly
imprinted
nanoparticles
(nanoMIPs)
targeted
toward
linear
epitope
estrogen
receptor
alfa
(ERα)
loaded
chemotherapeutic
doxorubicin.
These
nanoMIPs
cost-effective
rival
affinity
commercial
antibodies
for
ERα.
Upon
specific
binding
materials
ERα,
which
is
overexpressed
most
breast
cancers
(BCs),
nuclear
achieved
receptor-mediated
endocytosis.
Consequentially,
significantly
enhanced
cytotoxicity
elicited
BC
cell
lines
overexpressing
paving
way
precision
treatment
BC.
Proof-of-concept
clinical
use
provided
by
evaluating
efficacy
sophisticated
three-dimensional
(3D)
models,
capture
complexity
tumor
microenvironment
vivo
without
requiring
animal
models.
Thus,
findings
highlight
potential
promising
class
novel
compounds
ACS Nano,
Год журнала:
2022,
Номер
16(4), С. 5184 - 5232
Опубликована: Март 29, 2022
In
addition
to
the
contribution
of
cancer
cells,
solid
tumor
microenvironment
(TME)
has
a
critical
role
in
determining
expansion,
antitumor
immunity,
and
response
immunotherapy.
Understanding
details
complex
interplay
between
cells
components
TME
provides
an
unprecedented
opportunity
explore
combination
therapy
for
intervening
immune
landscape
improve
immunotherapy
outcome.
One
approach
is
introduction
multifunctional
nanocarriers,
capable
delivering
drug
combinations
that
provide
immunogenic
stimuli
improvement
antigen
presentation,
contemporaneous
with
delivery
coformulated
or
synthetic
molecules
danger
signals
interfere
immune-escape,
immune-suppressive,
T-cell
exclusion
pathways.
This
forward-looking
review
will
discuss
use
lipid-bilayer-encapsulated
liposomes
mesoporous
silica
nanoparticles
heterogeneous
landscapes
pancreatic
ductal
adenocarcinoma
triple-negative
breast
cancer.
We
describe
how
remote
loading
lipid
bilayer
encapsulation
used
synthesis
synergistic
induce
cell
death,
PD-1/PD-L1
axis,
inhibit
indoleamine-pyrrole
2,3-dioxygenase
(IDO-1)
metabolic
pathway,
restore
spatial
access
activated
T-cells
site,
reduce
impact
immunosuppressive
stromal
components.
show
integration
current
knowledge
future
discovery
can
be
rational
nanoenabled
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5021 - 5044
Опубликована: Май 1, 2024
Nanoparticle
systems
integrating
alginate
and
chitosan
emerge
as
a
promising
avenue
to
tackle
challenges
in
leveraging
the
potency
of
pharmacological
active
agents.
Owing
their
intrinsic
properties
polysaccharides,
chitosan,
exhibit
remarkable
biocompatibility,
rendering
them
conducive
bodily
integration.
By
downsizing
drug
particles
nano-scale,
system
enhances
solubility
aqueous
environments
by
augmenting
surface
area.
Additionally,
orchestrates
extended
release
kinetics,
aligning
well
with
exigencies
chronic
requisite
for
antibacterial
therapeutics.
A
thorough
scrutiny
existing
literature
underscores
wealth
evidence
supporting
utilization
alginate-chitosan
nanoparticle
agent
delivery.
Literature
reviews
present
abundant
based
on
combination
Various
experiments
demonstrate
enhanced
efficacy,
including
an
increase
inhibitory
zone
diameter,
improvement
minimum
concentration,
enhancement
bacterial
reduction
rate.
This
efficacy
occurs
due
mechanisms
involving
increased
resulting
from
particle
size
reduction,
prolonged
effects,
selectivity
towards
cell
walls,
stemming
ionic
interactions
between
positively
charged
teichoic
acid
walls.
However,
clinical
studies
remain
limited,
there
are
currently
no
marketed
drugs
utilizing
this
system.
Hence,
expediting
validation
is
crucial
maximize
its
benefits
promptly.
Materials,
Год журнала:
2021,
Номер
14(22), С. 6812 - 6812
Опубликована: Ноя. 11, 2021
Polymer-based
nanoparticles
of
tailored
size,
morphology,
and
surface
properties
have
attracted
increasing
attention
as
carriers
for
drugs,
biomolecules,
genes.
By
protecting
the
payload
from
degradation
maintaining
sustained
controlled
release
drug,
polymeric
can
reduce
drug
clearance,
increase
their
cargo’s
stability
solubility,
prolong
its
half-life,
ensure
optimal
concentration
at
target
site.
The
inherent
immunomodulatory
specific
polymer
nanoparticles,
coupled
with
encapsulation
ability,
raised
particular
interest
in
vaccine
delivery.
This
paper
aims
to
review
current
emerging
delivery
applications
both
branched
linear,
natural,
synthetic
nanostructures,
focusing
on
role
development.
Journal of Nanomaterials,
Год журнала:
2022,
Номер
2022, С. 1 - 12
Опубликована: Янв. 1, 2022
Albumin
is
derived
from
plasma
and
it
the
most
abundant
protein
in
plasma,
which
an
ideal
material
for
preparation
of
nanoparticles
because
its
good
biocompatibility,
noncytotoxicity,
nonimmunogenicity,
biodegradability,
so
on.
Besides,
albumin
can
enhance
targeting
drugs,
reduce
toxicity
free
water
solubility
hydrophobic
etc.
Drug
delivery
systems
based
on
are
widely
used
medical
field.
At
present,
main
methods
preparing
desolvation,
self-assembly,
thermal
gelation,
spray-drying,
double
emulsification,
Nab-technology,
pH
coacervation,
Due
to
differences
principle
conditions,
these
show
different
advantages
disadvantages.
This
review
systematically
summarizes
latest
research
progress
about
past
five
years,
also
introduces
applications
cancer
therapy,
existing
difficulties.
Thus,
this
fill
two
gaps
that
few
articles
focus
comprehensively
application
tumor
therapy
no
article
clearly
points
out
difficulties
faced
current
nanoparticles.
