Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(7), P. 770 - 784
Published: May 8, 2024
The
World
Health
Organization
(WHO)
reported
that
of
all
the
non-communicable
diseases,
cancer
is
considered
second
cause
death
worldwide.
This
has
driven
big
pharma
companies
to
prioritize
anticancer
products
in
their
pipeline.
In
addition,
research
focused
on
exploration
new
molecules
and
design
suitable
dosage
forms
achieve
effective
drug
delivery
tumor
site.
Nanotechnology
a
valuable
tool
build
nano
systems
with
controlled
targeted
release
properties.
Nanoparticles
can
be
fabricated
by
robust,
scalable
economic
techniques
using
various
polymers.
Moreover,
specific
functional
groups
introduced
surface
nanoparticles
enabling
targeting
tissue;
besides,
they
exhibit
versatile
patterns
according
rate
polymer
degradation.
review
outlines
processes
advances
functionalization
employed
for
treatment
breast
cancer.
therapeutic
molecules,
polymers
used
fabricate
nanoparticles,
prepare
have
been
reviewed
focus
functionalize
these
ligands
target
different
types
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 5184 - 5232
Published: March 29, 2022
In
addition
to
the
contribution
of
cancer
cells,
solid
tumor
microenvironment
(TME)
has
a
critical
role
in
determining
expansion,
antitumor
immunity,
and
response
immunotherapy.
Understanding
details
complex
interplay
between
cells
components
TME
provides
an
unprecedented
opportunity
explore
combination
therapy
for
intervening
immune
landscape
improve
immunotherapy
outcome.
One
approach
is
introduction
multifunctional
nanocarriers,
capable
delivering
drug
combinations
that
provide
immunogenic
stimuli
improvement
antigen
presentation,
contemporaneous
with
delivery
coformulated
or
synthetic
molecules
danger
signals
interfere
immune-escape,
immune-suppressive,
T-cell
exclusion
pathways.
This
forward-looking
review
will
discuss
use
lipid-bilayer-encapsulated
liposomes
mesoporous
silica
nanoparticles
heterogeneous
landscapes
pancreatic
ductal
adenocarcinoma
triple-negative
breast
cancer.
We
describe
how
remote
loading
lipid
bilayer
encapsulation
used
synthesis
synergistic
induce
cell
death,
PD-1/PD-L1
axis,
inhibit
indoleamine-pyrrole
2,3-dioxygenase
(IDO-1)
metabolic
pathway,
restore
spatial
access
activated
T-cells
site,
reduce
impact
immunosuppressive
stromal
components.
show
integration
current
knowledge
future
discovery
can
be
rational
nanoenabled
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 5021 - 5044
Published: May 1, 2024
Nanoparticle
systems
integrating
alginate
and
chitosan
emerge
as
a
promising
avenue
to
tackle
challenges
in
leveraging
the
potency
of
pharmacological
active
agents.
Owing
their
intrinsic
properties
polysaccharides,
chitosan,
exhibit
remarkable
biocompatibility,
rendering
them
conducive
bodily
integration.
By
downsizing
drug
particles
nano-scale,
system
enhances
solubility
aqueous
environments
by
augmenting
surface
area.
Additionally,
orchestrates
extended
release
kinetics,
aligning
well
with
exigencies
chronic
requisite
for
antibacterial
therapeutics.
A
thorough
scrutiny
existing
literature
underscores
wealth
evidence
supporting
utilization
alginate-chitosan
nanoparticle
agent
delivery.
Literature
reviews
present
abundant
based
on
combination
Various
experiments
demonstrate
enhanced
efficacy,
including
an
increase
inhibitory
zone
diameter,
improvement
minimum
concentration,
enhancement
bacterial
reduction
rate.
This
efficacy
occurs
due
mechanisms
involving
increased
resulting
from
particle
size
reduction,
prolonged
effects,
selectivity
towards
cell
walls,
stemming
ionic
interactions
between
positively
charged
teichoic
acid
walls.
However,
clinical
studies
remain
limited,
there
are
currently
no
marketed
drugs
utilizing
this
system.
Hence,
expediting
validation
is
crucial
maximize
its
benefits
promptly.
Journal of Nanomaterials,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 12
Published: Jan. 1, 2022
Albumin
is
derived
from
plasma
and
it
the
most
abundant
protein
in
plasma,
which
an
ideal
material
for
preparation
of
nanoparticles
because
its
good
biocompatibility,
noncytotoxicity,
nonimmunogenicity,
biodegradability,
so
on.
Besides,
albumin
can
enhance
targeting
drugs,
reduce
toxicity
free
water
solubility
hydrophobic
etc.
Drug
delivery
systems
based
on
are
widely
used
medical
field.
At
present,
main
methods
preparing
desolvation,
self-assembly,
thermal
gelation,
spray-drying,
double
emulsification,
Nab-technology,
pH
coacervation,
Due
to
differences
principle
conditions,
these
show
different
advantages
disadvantages.
This
review
systematically
summarizes
latest
research
progress
about
past
five
years,
also
introduces
applications
cancer
therapy,
existing
difficulties.
Thus,
this
fill
two
gaps
that
few
articles
focus
comprehensively
application
tumor
therapy
no
article
clearly
points
out
difficulties
faced
current
nanoparticles.
