Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(18), С. 3925 - 3934
Опубликована: Янв. 1, 2021
We creatively designed a nanodrug delivery system of MnO2-PTX/Ce6@lips based on the catalytic activity MnO2 NPs. synthesized highly dispersible catalase-like nanozyme and successfully encapsulated it into liposomes.
Язык: Английский
Acta Biomaterialia, Год журнала: 2021, Номер 135, С. 617 - 627
Опубликована: Авг. 15, 2021
Язык: Английский
Процитировано
48
Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(41)
Опубликована: Июль 18, 2022
Abstract The delivery of glucose oxidase (GOx) requires extra carriers, which suffers from early leakage and exposure GOx. These issues will be less concern if GOx itself acts as a drug carrier. However, the catalytic activity in blood still needs to inhibited. Herein, we found that could self‐assemble with hydrophobic molecules into uniform stable nanoparticles (NPs), including sorafenib, 4′‐(amino‐methyl phenyl)‐2,2′ : 6′,2′′‐terpyridine modified cyanin paclitaxel. NPs was significantly inhibited due binding small its pockets. After dissociation tumor acidic microenvironment, enzyme largely recovered. This acidity‐triggered “OFF‐to‐ON” process ensured safe intravenous administration GOx‐based NPs. In vivo experiments showed combined starvation therapy ferroptosis/photothermal therapy/chemotherapy effectively 4T1 breast growth.
Язык: Английский
Процитировано
37
Acta Biomaterialia, Год журнала: 2022, Номер 151, С. 600 - 612
Опубликована: Авг. 9, 2022
Язык: Английский
Процитировано
36
Journal of Materials Chemistry B, Год журнала: 2022, Номер 10(6), С. 966 - 976
Опубликована: Янв. 1, 2022
Developing an integrated multimodal diagnosis and therapeutics nanoplatform is of great importance to enhance the outcome cancer therapy. Herein, we report a highly efficient biocompatible based on assembly graphene oxide (GO) metal-organic framework (MOF) Fe-porphyrin, which was coated with folate-functionalized erythrocyte membrane (FA-EM@GO-MOF). The could be targeted cells precisely, avoid immune elimination had prolonged blood circulation due presence FA-EM its surface. GO paramagnetic Fe ions endowed robust fluorescence imaging T2-weighted magnetic resonance capacities. porous structure large surface area GO-MOF make it desirable for drug delivery in chemotherapy. More importantly, one operation, under same laser (808 nm) irradiation, both photothermal therapy photodynamic triggered synergistic treatment by using MOF as photosensitizer. This anticancer promoted generation tumor-associated antigens evoked antitumor response. In vitro vivo studies highlighted that as-fabricated biomimetic dual imaging-guided effective yet straightforward, paving new avenue
Язык: Английский
Процитировано
35
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
8
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Март 13, 2024
Photodynamic therapy (PDT), a promising treatment modality, employs photosensitizers to generate cytotoxic reactive oxygen species (ROS) within localized tumor regions. This technique involves administering photosensitizer followed by light activation in the presence of (O 2 ), resulting ROS production. PDT’s spatiotemporal selectivity, minimally invasive nature, and compatibility with other modalities make it compelling therapeutic approach. However, hypoxic microenvironment (TME) poses significant challenge conventional PDT. To overcome this hurdle, various strategies have been devised, including in-situ O generation, targeted delivery, vasculature normalization, modulation mitochondrial respiration, photocatalytic generation. review aims provide comprehensive overview recent developments designing tumor-oxygenated nanomaterials enhance PDT efficacy. Furthermore, we delineate ongoing challenges propose improve clinical impact cancer treatment.
Язык: Английский
Процитировано
7
Acta Biomaterialia, Год журнала: 2020, Номер 117, С. 361 - 373
Опубликована: Сен. 29, 2020
Язык: Английский
Процитировано
45
Theranostics, Год журнала: 2021, Номер 11(14), С. 7045 - 7056
Опубликована: Янв. 1, 2021
Precise treatment of tumors is attracting increasing attention. Molecular probes simultaneously demonstrating the diagnostic signal and pharmacological effect in response to tumor microenvironment are highly desired. γ-glutamyl transpeptidase (GGT) a biomarker with significantly up-regulated expression area. We developed GGT responsive near-infrared (NIR) nanoassembly for tumor-specific fluorescence imaging-guided photothermal therapy.
Язык: Английский
Процитировано
37
Materials Advances, Год журнала: 2022, Номер 3(9), С. 3709 - 3725
Опубликована: Янв. 1, 2022
Nano-sensitizers play key roles in tumor radiotherapy several ways to overcome radioresistance and enhance radioresponse. This review summarizes the recent advances of nano-sensitizers improving cancer radiotherapy.
Язык: Английский
Процитировано
25
Nanomedicine, Год журнала: 2023, Номер 18(1), С. 35 - 52
Опубликована: Янв. 1, 2023
Aim: Achieving drug-targeting delivery and environment-responsive releasing to realize imaging-guided precise tumor therapy. Materials & methods: Graphene oxide (GO) was used as the drug-delivery system load indocyanine green (ICG) doxorubicin (DOX) form a GO/ICG&DOX nanoplatform, in which GO can quench fluorescence of ICG DOX. MnO2 folate acid-functionalized erythrocyte membrane were further coated into surface obtain an FA-EM@MnO2-GO/ICG&DOX nanoplatform. Results: The nanoplatform has longer blood circulation time, targeting tissues catalase-like activity. Both vitro vivo results demonstrated that better therapeutic efficacy. Conclusion: authors successfully fabricated glutathione-responsive achieve drug release.
Язык: Английский
Процитировано
13