Advanced Materials Interfaces,
Год журнала:
2021,
Номер
8(20)
Опубликована: Сен. 17, 2021
Abstract
Field‐effect
transistors
(FETs)
with
nanoscale
channels
have
emerged
as
excellent
platforms
for
constructing
high‐sensitivity
biosensors.
However,
in
typical
FET‐based
biosensors,
the
electronic
perturbation
at
channel/electrolyte
interfaces
results
poor
stability
and
severe
signal
drifts,
making
long‐term
continuous
measurements
quite
challenging.
To
address
this
issue,
here
dielectric/semiconductor
interface
is
tailored
by
depositing
an
ultrathin
layer
of
Al
2
O
3
(≈7
nm
thickness)
on
In
FETs
via
solution‐based
processes.
The
show
that
dielectric
layers
effectively
passivate
channel
endow
device
low
operation
voltage
(0.05
V),
high
sensitivity
(61.9
mV
pH
−1
),
current
drift
(0.35
h
)
upon
monitoring.
This
work
paves
way
to
real‐time
biosensing
sensitivity,
stability,
power
consumption.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5211 - 5295
Опубликована: Март 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Chemical Reviews,
Год журнала:
2022,
Номер
122(11), С. 10319 - 10392
Опубликована: Апрель 12, 2022
The
evolutionary
success
in
information
technology
has
been
sustained
by
the
rapid
growth
of
sensor
technology.
Recently,
advances
have
promoted
ambitious
requirement
to
build
intelligent
systems
that
can
be
controlled
external
stimuli
along
with
independent
operation,
adaptivity,
and
low
energy
expenditure.
Among
various
sensing
techniques,
field-effect
transistors
(FETs)
channels
made
two-dimensional
(2D)
materials
attract
increasing
attention
for
advantages
such
as
label-free
detection,
fast
response,
easy
capability
integration.
With
atomic
thickness,
2D
restrict
carrier
flow
within
material
surface
expose
it
directly
environment,
leading
efficient
signal
acquisition
conversion.
This
review
summarizes
latest
2D-materials-based
FET
(2D
FET)
sensors
a
comprehensive
manner
contains
material,
operating
principles,
fabrication
technologies,
proof-of-concept
applications,
prototypes.
First,
brief
description
background
fundamentals
is
provided.
subsequent
contents
summarize
physical,
chemical,
biological
their
applications.
Then,
we
highlight
challenges
commercialization
discuss
corresponding
solution
techniques.
following
section
presents
systematic
survey
recent
progress
developing
commercial
Lastly,
long-standing
efforts
prospective
future
development
FET-based
toward
commercialization.
Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(41), С. 17004 - 17014
Опубликована: Окт. 8, 2021
Rapid
screening
of
infected
individuals
from
a
large
population
is
an
effective
means
in
epidemiology,
especially
to
contain
outbreaks
such
as
COVID-19.
The
gold
standard
assays
for
COVID-19
diagnostics
are
mainly
based
on
the
reverse
transcription
polymerase
chain
reaction,
which
mismatches
requirements
wide-population
due
time-consuming
nucleic
acid
extraction
and
amplification
procedures.
Here,
we
report
direct
assay
by
using
graphene
field-effect
transistor
(g-FET)
with
Y-shaped
DNA
dual
probes
(Y-dual
probes).
relies
Y-dual
modified
g-FET
simultaneously
targeting
ORF1ab
N
genes
SARS-CoV-2
acid,
enabling
high
recognition
ratio
limit
detection
(0.03
copy
μL–1)
1–2
orders
magnitude
lower
than
existing
assays.
realizes
fastest
testing
(∼1
min)
achieves
5-in-1
pooled
first
time.
Owing
its
rapid,
ultrasensitive,
easily
operated
features
well
capability
testing,
it
holds
great
promise
comprehensive
tool
population-wide
other
epidemics.
Interfacing
artificial
devices
with
the
human
brain
is
central
goal
of
neurotechnology.
Yet,
our
imaginations
are
often
limited
by
currently
available
paradigms
and
technologies.
Suggestions
for
brain-machine
interfaces
have
changed
over
time,
along
technology.
Mechanical
levers
cable
winches
were
used
to
move
parts
during
mechanical
age.
Sophisticated
electronic
wiring
remote
control
arisen
age,
ultimately
leading
plug-and-play
computer
interfaces.
Nonetheless,
brains
so
complex
that
these
visions,
until
recently,
largely
remained
unreachable
dreams.
The
general
problem,
thus
far,
most
technology
mechanically
and/or
electrically
engineered,
whereas
a
living,
dynamic
entity.
As
result,
worlds
difficult
interface
one
another.
Nanotechnology,
which
encompasses
engineered
solid-state
objects
integrated
circuits,
excels
at
small
length
scales
single
few
hundred
nanometers
and,
thus,
matches
sizes
biomolecules,
biomolecular
assemblies,
cells.
Consequently,
we
envision
nanomaterials
nanotools
as
opportunities
in
alternative
ways.
Here,
review
existing
literature
on
use
nanotechnology
look
forward
discussing
perspectives
limitations
based
authors'
expertise
across
range
complementary
disciplines─from
neuroscience,
engineering,
physics,
chemistry
biology
medicine,
science
mathematics,
social
jurisprudence.
We
focus
but
also
include
information
from
related
fields
when
useful
complementary.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июль 26, 2023
Genetic
analysis
methods
are
foundational
to
advancing
personalized
and
preventative
medicine,
accelerating
disease
diagnostics,
monitoring
the
health
of
organisms
ecosystems.
Current
nucleic
acid
technologies
such
as
polymerase
chain
reaction
(PCR),
next-generation
sequencing
(NGS),
DNA
microarrays
rely
on
fluorescence
absorbance,
necessitating
sample
amplification
or
replication
leading
increased
processing
time
cost.
Here,
we
introduce
a
label-free
genetic
screening
platform
based
high
quality
(high-Q)
factor
silicon
nanoantennas
functionalized
with
monolayers
fragments.
Each
nanoantenna
exhibits
substantial
electromagnetic
field
enhancements
sufficiently
localized
fields
ensure
isolation
from
neighboring
resonators,
enabling
dense
biosensor
integration.
We
quantitatively
detect
complementary
target
sequences
using
hybridization
simultaneously
for
arrays
sensing
elements
patterned
at
densities
160,000
pixels
per
cm$^2$.
In
physiological
buffer,
our
exhibit
average
resonant
factors
2,200,
allowing
detection
two
gene
fragments,
SARS-CoV-2
envelope
(E)
open
reading
frame
1b
(ORF1b),
down
femtomolar
concentrations.
also
demonstrate
specificity
in
clinical
nasopharyngeal
eluates
within
5
minutes
introduction.
Combined
advances
biomarker
complex
samples
(e.g.,
mucus,
blood,
wastewater),
work
provides
foundation
rapid,
compact,
amplification-free
throughput
multiplexed
assays
spanning
medical
diagnostics
environmental
monitoring.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(31)
Опубликована: Май 10, 2023
Abstract
Biomarkers
are
primary
indicators
for
precise
diagnosis
and
treatment.
The
early
identification
of
health
biomarkers
has
been
sustained
by
the
evolutionary
success
in
sensor
technologies.
Among
them,
graphene
field‐effect
transistor
(GFET)
biosensors
have
exhibited
major
advantages
such
as
an
ultrashort
response
time,
high
sensitivity,
easy
operation,
capability
integration,
label‐free
detection.
Owing
to
atomic
thickness,
restricts
charge
carrier
flow
merely
at
material
surface
responds
foreign
stimuli
directly,
leading
effective
signal
acquisition
transmission.
Here,
this
review
summarizes
latest
advances
GFET
a
comprehensive
manner
that
contains
device
design,
working
principle,
functionalization,
proof‐of‐concept
applications.
It
provides
survey
with
regard
biomarker
analysis
single‐device
level
integrated
prototypes
include
wearable
sensors,
biomimetic
systems,
healthcare
electronics,
diagnostic
platforms.
Moreover,
there
is
discussion
on
long‐standing
research
efforts
outlook
future
development
systems
from
lab
fab.
ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 31713 - 31736
Опубликована: Ноя. 7, 2024
Sensitive
and
quantitative
detection
of
chemical
biological
molecules
for
screening,
diagnosis
monitoring
diseases
is
essential
to
treatment
planning
response
monitoring.
Electrochemical
biosensors
are
fast,
sensitive,
easy
miniaturize,
which
has
led
rapid
development
in
clinical
diagnosis.
Benefiting
from
their
excellent
molecular
recognition
ability
high
programmability,
DNA
nanomaterials
could
overcome
the
Debye
length
electrochemical
by
simple
design
well
suited
as
elements
biosensors.
Therefore,
enhance
sensitivity
specificity
biosensors,
significant
progress
been
made
recent
years
optimizing
design.
Here,
establishment
sensing
strategies
based
on
reviewed
detail.
First,
structural
nanomaterial
examined
improving
overcoming
length.
In
addition,
electrical
signal
transduction
amplification
reviewed,
applications
nanomaterial-based
integrated
devices
further
summarized.
Finally,
main
opportunities
challenges
detecting
disease
biomarkers
presented
an
aim
guide
with
specificity.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(43), С. 18304 - 18309
Опубликована: Окт. 13, 2020
Strong
enhancement
of
molecular
circular
dichroism
has
the
potential
to
enable
efficient
asymmetric
photolysis,
a
method
chiral
separation
that
conventionally
been
impeded
by
insufficient
yield
and
low
enantiomeric
excess.
Here,
we
study
experimentally
how
predicted
enhancements
in
optical
chirality
density
near
resonant
silicon
nanodisks
boost
dichroism.
We
use
fluorescence-detected
spectroscopy
measure
indirectly
differential
absorption
circularly
polarized
light
monolayer
optically
active
molecules
functionalized
nanodisk
arrays.
Importantly,
antennas
have
spectrally-coincident
resonances,
our
fluorescence
technique
allows
us
deconvolute
from
molecules.
find
enhanced
signals
depend
on
nanophotonic
resonances
good
agreement
with
simulated
density,
while
no
signal
is
detected
adsorbed
featureless
surfaces.
These
results
verify
platforms
be
used
for
photolysis
lower
energy
requirements
