Analysis & Sensing,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Abstract
Given
high
levels
of
both
K
+
and
H
in
the
tumor
microenvironment,
G‐quadruplex
(G4)
i‐motif
can
principle
be
utilized
as
two
cooperative
modules
to
build
logic‐gated
DNA
nanodevices
for
microenvironment
recognition
targeting.
Combined
use
G4
nanoassemblies,
however,
usually
causes
uncontrolled
aggregation.
To
address
this
trouble,
we
well
design
a
novel
i‐motif/G‐quadruplex
(iG4)
hybrid
structure
that
integrates
four‐stranded
helices
folding
topology,
with
parallel
mini‐duplex
flanking
at
5’
end
provide
binding
site
fluorescent
ligands.
This
enables
folded
lighting‐up
is
favored
by
together,
consistent
two‐input
AND
gate
behavior.
We
then
employ
iG4
guide
nanotweezer
clamped
an
altered
split
ATP
aptamer,
which
brings
proximity
effect
contributing
proper
slightly
acidic
microenvironments
sensitive
detection
endogenous
cancer
cell
lysates.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Nanostructures
integrating
pH-sensitive
DNA
motifs
have
emerged
as
versatile
platforms
for
active
tumor
targeting,
owing
to
their
ability
undergo
conformation
changes
in
response
the
common
acidic
environment
of
extracellular
matrix
and
endocytosis
pathway.
This
review
summarizes
latest
advances
design
application
various
pH-responsive
nanostructures
tumor-targeted
strategies,
including
recognition,
cell
imaging,
dynamic
nanocarrier
construction,
controlled
drug
release.
A
comprehensive
framework
pH-controlled
multi-stage
targeting
is
introduced,
addressing
divergences
strategies
intracellular
environments.
The
unique
attributes,
practical
performance
challenges
are
also
critically
discussed
provide
guidance
future
development
this
field.
Abstract
Current
tumor
vaccines
suffer
from
inadequate
immune
responsive
due
to
the
insufficient
release
of
antigens,
low
infiltration,
and
immunosuppressive
microenvironment.
DNA
nanostructures
with
their
ability
precisely
engineer,
controlled
release,
biocompatibility,
capability
augment
immunogenicity
microenvironment,
have
gained
significant
attention
for
potential
revolutionize
vaccine
designing.
This
review
summarizes
various
applications
in
construction
situ
cancer
vaccines,
which
can
generate
tumor‐associated
antigens
directly
damaged
tumors
immune‐stimulation.
The
mechanisms
components
are
listed,
specific
strategies
constructing
using
explored
underlying
action
elucidated.
immunogenic
cell
death
(ICD)
induced
by
chemotherapeutic
agents,
photothermal
therapy
(PTT),
photodynamic
(PDT),
radiation
(RT)
related
building
systematically
summarized.
different
immunotherapy
elaborated,
exerts
precise,
long‐lasting,
robust
responses.
current
challenges
future
prospectives
proposed.
provides
a
holistic
understanding
evolving
role
development.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 12, 2024
Abstract
Nucleic
acid
nanostructures,
derived
from
the
assembly
of
nucleic
building
blocks
(e.g.,
plasmids
and
oligonucleotides),
are
important
intracellular
carriers
therapeutic
cargoes
widely
utilized
in
preclinical
nanomedicine
applications,
yet
their
clinical
translation
remains
scarce.
In
era
“translational
nanotechnology”,
a
deeper
mechanistic
understanding
interactions
nanostructures
with
cells
vivo
will
guide
development
more
efficacious
nanomedicines.
This
review
showcases
recent
progress
dissecting
four
key
types
(i.e.,
tile‐based,
origami,
spherical
acid,
nanogel)
rodents
over
past
five
years.
Emphasis
lies
on
cellular‐level
distribution
various
organs
tissues
cellular
responses
induced
by
entry.
Next,
spirit
translation,
this
features
latest
large
animals
humans.
Finally,
offers
directions
for
studying
both
materials
biology
perspectives
concludes
some
regulatory
updates.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Ноя. 28, 2024
Cancer
vaccines
have
garnered
attention
as
a
potential
treatment
for
cancer
metastases.
Nevertheless,
the
clinical
response
rate
to
remains
<
30%.
Nanoparticles
stabilize
and
improve
antigen
recognition
presentation,
resulting
in
high
tumor
penetration
or
accumulation,
effective
co-distribution
of
drugs
secondary
lymphatic
system,
adaptable
adjuvant
administration.
Such
vaccine-like
nanomedicines
ability
eradicate
primary
tumors
well
prevent
eliminate
This
review
examines
state-of-the-art
nanocarriers
developed
deliver
metastases,
including
synthetic,
semi-biogenic,
biogenic
nanosystems.
Moreover,
it
highlights
physical
pharmacological
properties
that
enhance
their
anti-metastasis
efficiency.
also
addresses
combination
nanovaccines
with
immunotherapy
target
various
steps
metastatic
cascade,
drawing
insights
from
preclinical
studies.
The
concludes
critical
analysis
challenges
frameworks
linked
translation
nanovaccines.
Advanced Therapeutics,
Год журнала:
2024,
Номер
7(12)
Опубликована: Ноя. 1, 2024
Abstract
MicroRNAs
(miRs)
play
a
critical
role
in
modulating
gene
expression
across
biological
processes,
including
cardiac
aging
and
disease.
As
such,
miRs
have
demonstrated
therapeutic
potential
several
conditions.
Efficient
delivery
of
miR
therapies
to
tissue
is
crucial
for
effective
therapy
DNA‐based
nanocarriers
(DNCs),
based
on
Watson‐Crick‐Franklin
highly
specific
base‐pair
recognition,
emerged
as
promising,
biocompatible
alternative
viral‐based
methods.
Here,
DNCs
designed
modulate
levels
treatment
dysfunction
are
presented.
Specifically,
the
target
miR‐24‐2,
which
inhibits
SERCA2
gene.
In
humans,
reduction
activity
hallmark
heart
failure
altered
aging.
The
assembled
bearing
anti‐miR‐24‐2‐5p
sequences
effectively
restore
intracellular
HEK293
cell
model.
proper
assembly
thoroughly
verified,
while
their
stability
miR‐capture
ability
vitro.
exhibit
successful
internalization
into
modest
uptake
human
cardiomyocytes.
restoration
by
significantly
influenced
sequence
layout,
underscoring
importance
precise
design
optimal
outcomes.
This
study
highlights
therapies,
previously
unexplored
avenue
addressing
dysfunction.
Analysis & Sensing,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Abstract
Given
high
levels
of
both
K
+
and
H
in
the
tumor
microenvironment,
G‐quadruplex
(G4)
i‐motif
can
principle
be
utilized
as
two
cooperative
modules
to
build
logic‐gated
DNA
nanodevices
for
microenvironment
recognition
targeting.
Combined
use
G4
nanoassemblies,
however,
usually
causes
uncontrolled
aggregation.
To
address
this
trouble,
we
well
design
a
novel
i‐motif/G‐quadruplex
(iG4)
hybrid
structure
that
integrates
four‐stranded
helices
folding
topology,
with
parallel
mini‐duplex
flanking
at
5’
end
provide
binding
site
fluorescent
ligands.
This
enables
folded
lighting‐up
is
favored
by
together,
consistent
two‐input
AND
gate
behavior.
We
then
employ
iG4
guide
nanotweezer
clamped
an
altered
split
ATP
aptamer,
which
brings
proximity
effect
contributing
proper
slightly
acidic
microenvironments
sensitive
detection
endogenous
cancer
cell
lysates.
