Published: Jan. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Abstract Nucleic acid nanostructures, derived from the assembly of nucleic building blocks (e.g., plasmids and oligonucleotides), are important intracellular carriers therapeutic cargoes widely utilized in preclinical nanomedicine applications, yet their clinical translation remains scarce. In era “translational nanotechnology”, a deeper mechanistic understanding interactions nanostructures with cells vivo will guide development more efficacious nanomedicines. This review showcases recent progress dissecting four key types (i.e., tile‐based, origami, spherical acid, nanogel) rodents over past five years. Emphasis lies on cellular‐level distribution various organs tissues cellular responses induced by entry. Next, spirit translation, this features latest large animals humans. Finally, offers directions for studying both materials biology perspectives concludes some regulatory updates.
Language: Английский
Citations
3
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Nanostructures integrating pH-sensitive DNA motifs have emerged as versatile platforms for active tumor targeting, owing to their ability undergo conformation changes in response the common acidic environment of extracellular matrix and endocytosis pathway. This review summarizes latest advances design application various pH-responsive nanostructures tumor-targeted strategies, including recognition, cell imaging, dynamic nanocarrier construction, controlled drug release. A comprehensive framework pH-controlled multi-stage targeting is introduced, addressing divergences strategies intracellular environments. The unique attributes, practical performance challenges are also critically discussed provide guidance future development this field.
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673
Published: April 3, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154698 - 154698
Published: Aug. 13, 2024
Language: Английский
Citations
3
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 28, 2024
Cancer vaccines have garnered attention as a potential treatment for cancer metastases. Nevertheless, the clinical response rate to remains < 30%. Nanoparticles stabilize and improve antigen recognition presentation, resulting in high tumor penetration or accumulation, effective co-distribution of drugs secondary lymphatic system, adaptable adjuvant administration. Such vaccine-like nanomedicines ability eradicate primary tumors well prevent eliminate This review examines state-of-the-art nanocarriers developed deliver metastases, including synthetic, semi-biogenic, biogenic nanosystems. Moreover, it highlights physical pharmacological properties that enhance their anti-metastasis efficiency. also addresses combination nanovaccines with immunotherapy target various steps metastatic cascade, drawing insights from preclinical studies. The concludes critical analysis challenges frameworks linked translation nanovaccines.
Language: Английский
Citations
2
Published: Jan. 1, 2024
Language: Английский
Citations
0
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 420, P. 136385 - 136385
Published: Aug. 3, 2024
Language: Английский
Citations
0
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)
Published: Nov. 1, 2024
Abstract MicroRNAs (miRs) play a critical role in modulating gene expression across biological processes, including cardiac aging and disease. As such, miRs have demonstrated therapeutic potential several conditions. Efficient delivery of miR therapies to tissue is crucial for effective therapy DNA‐based nanocarriers (DNCs), based on Watson‐Crick‐Franklin highly specific base‐pair recognition, emerged as promising, biocompatible alternative viral‐based methods. Here, DNCs designed modulate levels treatment dysfunction are presented. Specifically, the target miR‐24‐2, which inhibits SERCA2 gene. In humans, reduction activity hallmark heart failure altered aging. The assembled bearing anti‐miR‐24‐2‐5p sequences effectively restore intracellular HEK293 cell model. proper assembly thoroughly verified, while their stability miR‐capture ability vitro. exhibit successful internalization into modest uptake human cardiomyocytes. restoration by significantly influenced sequence layout, underscoring importance precise design optimal outcomes. This study highlights therapies, previously unexplored avenue addressing dysfunction.
Language: Английский
Citations
0
Analysis & Sensing, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 8, 2024
Abstract Given high levels of both K + and H in the tumor microenvironment, G‐quadruplex (G4) i‐motif can principle be utilized as two cooperative modules to build logic‐gated DNA nanodevices for microenvironment recognition targeting. Combined use G4 nanoassemblies, however, usually causes uncontrolled aggregation. To address this trouble, we well design a novel i‐motif/G‐quadruplex (iG4) hybrid structure that integrates four‐stranded helices folding topology, with parallel mini‐duplex flanking at 5’ end provide binding site fluorescent ligands. This enables folded lighting‐up is favored by together, consistent two‐input AND gate behavior. We then employ iG4 guide nanotweezer clamped an altered split ATP aptamer, which brings proximity effect contributing proper slightly acidic microenvironments sensitive detection endogenous cancer cell lysates.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0