Pore engineering of Porous Materials: Effects and Applications

ACS Nano, Год журнала: 2024, Номер 18(34), С. 22829 - 22854

Опубликована: Авг. 17, 2024

Porous materials, characterized by their controllable pore size, high specific surface area, and controlled space functionality, have become cross-scale structures with microenvironment effects multiple functions gained tremendous attention in the fields of catalysis, energy storage, biomedicine. They evolved from initial nanopores to multiscale pore-cavity designs yolk-shell, multishells, or asymmetric structures, such as bottle-shaped, multichambered, branching architectures. Various synthesis strategies been developed for interfacial engineering porous including bottom-up approaches using liquid-liquid liquid-solid interfaces "templating" top-down toward chemical tailoring polymers different cross-linking degrees, well interface transformation Oswald ripening, Kirkendall effect, atomic diffusion rearrangement methods. These techniques permit design functional materials diverse effects, size enrichment isolation synergistic local field enhancement enhanced applications. In this review, we delve into interfacial-oriented advanced effects. We also discuss recent progress applications these collaborative structure-activity relationships areas electrochemical conversion, Finally, outline persisting obstacles prospective avenues terms functionalization engineering. The perspectives proposed paper may contribute promote wider various interdisciplinary within confined dimensions structures.

Язык: Английский

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NIR‐Actuated Ferroptosis Nanomotor for Enhanced Tumor Penetration and Therapy

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Abstract Ferroptosis nano‐inducers have drawn considerable attention in the treatment of malignant tumors. However, low intratumoral hydrogen peroxide level and complex biological barriers hinder ability nanomedicines to generate sufficient reactive oxygen species (ROS) achieve tumor penetration. Here a near‐infrared (NIR)‐driven ROS self‐supplying nanomotor is successfully designed for synergistic chemodynamic therapy (CDT) photothermal (PTT). Janus created by asymmetrical modification polydopamine (PDA) with zinc (ZnO 2 ) subsequent ferrous ion (Fe 2+ chelation via polyphenol groups from PDA, here refer as ZnO @PDA‐Fe (Z@P‐F). capable slowly releasing (H O into an acidic microenvironment (TME) providing ingredients Fenton reaction necessary ferroptosis. Upon NIR laser irradiation, loaded Fe released thermal gradient simultaneously formed owing asymmetric PDA coating, thus endowing self‐thermophoresis based enhanced diffusion lysosomal escape Therefore, release ions ), self‐supplied H , nanomotors actuation further improve CDT/PTT efficacy, showing great potential active therapy.

Язык: Английский

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Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 665, С. 681 - 692

Опубликована: Март 27, 2024

Язык: Английский

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Understanding the chemistry of mesostructured porous nanoreactors

Nature Reviews Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Язык: Английский

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Cholesterol Depletion‐Enhanced Ferroptosis and Immunotherapy via Engineered Nanozyme

Advanced Science, Год журнала: 2024, Номер 11(38)

Опубликована: Авг. 9, 2024

Ferroptosis, an iron- and reactive oxygen species (ROS)-dependent cell death, holds significant promise for tumor therapy due to its ability induce lipid peroxidation (LPO) trigger antitumor immune responses. However, elevated cholesterol levels in cancer cells impede ferroptosis compromise function. Here, a novel nanozyme, Fe-MOF/CP, composed of iron metal-organic framework (Fe-MOF) nanoparticles loaded with oxidase PEGylation integrated immunotherapy is introduced. Fe-MOF/CP depletes generates hydrogen peroxide, enhancing ROS inducing LPO, thereby promoting ferroptosis. This process disrupts raft integrity downregulates glutathione peroxidase 4 suppressor protein 1, further facilitating Concurrently, augments immunogenic reduces programmed death-ligand 1 expression, revitalizes exhausted CD8

Язык: Английский

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Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.

Язык: Английский

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Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma

Nano Letters, Год журнала: 2024, Номер 24(29), С. 8996 - 9003

Опубликована: Июль 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Язык: Английский

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Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo

Bioactive Materials, Год журнала: 2024, Номер 44, С. 488 - 500

Опубликована: Ноя. 5, 2024

Язык: Английский

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Qualitative behaviors of the Fenton reaction system

Discrete and Continuous Dynamical Systems - B, Год журнала: 2025, Номер 0(0), С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

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Interfacial templating strategy for asymmetric mesoporous materials: Synthesis and typical applications

Next Materials, Год журнала: 2024, Номер 2, С. 100144 - 100144

Опубликована: Янв. 1, 2024

Asymmetric mesoporous materials have attracted enormous attention due to their unique anisotropic architectures, composition and functional asymmetry, on the basis of inheriting advantages traditional (large surface area, tunable pore size, etc.). The popularity asymmetric stems from special properties derived structures. individual portions can be selectively modified function independently, achieving coordination without mutual interference, which holds great potential for use in catalysis, energy conversion storage, biomedicine, etc. Generally, inspiration synthesis comes methods, modulation interface template make architectures grow symmetric asymmetric. Therefore, types interfaces (gas-solid, liquid-solid, liquid-liquid interface) play an important role construction architectures. Through precise manipulation assembly micelles at diverse interfaces, with distinct structures been synthesized, such as dumbbell-like, tadpole-like, calabash-shape, also multi-level Nowadays, growing demands complexity application scenarios, nanomaterials novel structures, morphologies, compositions functions are urgently needed. In this review, both characteristic applications systematically summarized. We highlight synthetic strategies examples via interfacial templating approach, including selective deposition gas-solid or alteration liquid-solid interfaces. addition, specific these structure-activity relationships domains electrochemical biomedicine discussed. Finally, challenges perspectives field future outlook proposed.

Язык: Английский

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