X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis DOI

Yuanyuan You,

Wenxiao Jiang, Renhao Xu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Radiotherapy‐induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4‐(2‐aminoethyl) benzenesulfonamide (ABS) constructed form DSiMn‐ABS nanosystem improve sensitivity hypoxic cells radiotherapy effect. The can be continuously degraded environment X‐rays, releasing Manganese dioxid （MnO 2 )and ABS; Thereby inhibiting activity CA IX, inducing acidification inside cells, regulating AMP‐activating protein kinase (AMPK)/Acetyl‐CoA carboxylase(ACC) axis increase ferroptosis, depleting glutathione (GSH) through MnO influencing peroxidase 4 (GPX4) activity, which further inhibits defense ultimately effectively improves therapeutic efficiency radiotherapy. Ultimately, inhibit growth. Therefore, this utilize double‐sensitized provide new ideas for

Language: Английский

Pore engineering of Porous Materials: Effects and Applications DOI
Aixia Wang, Yuzhu Ma, Dongyuan Zhao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22829 - 22854

Published: Aug. 17, 2024

Porous materials, characterized by their controllable pore size, high specific surface area, and controlled space functionality, have become cross-scale structures with microenvironment effects multiple functions gained tremendous attention in the fields of catalysis, energy storage, biomedicine. They evolved from initial nanopores to multiscale pore-cavity designs yolk-shell, multishells, or asymmetric structures, such as bottle-shaped, multichambered, branching architectures. Various synthesis strategies been developed for interfacial engineering porous including bottom-up approaches using liquid-liquid liquid-solid interfaces "templating" top-down toward chemical tailoring polymers different cross-linking degrees, well interface transformation Oswald ripening, Kirkendall effect, atomic diffusion rearrangement methods. These techniques permit design functional materials diverse effects, size enrichment isolation synergistic local field enhancement enhanced applications. In this review, we delve into interfacial-oriented advanced effects. We also discuss recent progress applications these collaborative structure-activity relationships areas electrochemical conversion, Finally, outline persisting obstacles prospective avenues terms functionalization engineering. The perspectives proposed paper may contribute promote wider various interdisciplinary within confined dimensions structures.

Language: Английский

Citations

34
NIR‐Actuated Ferroptosis Nanomotor for Enhanced Tumor Penetration and Therapy DOI

Ziwei Hu,

Haixin Tan,

Yicheng Ye

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 6, 2024

Abstract Ferroptosis nano‐inducers have drawn considerable attention in the treatment of malignant tumors. However, low intratumoral hydrogen peroxide level and complex biological barriers hinder ability nanomedicines to generate sufficient reactive oxygen species (ROS) achieve tumor penetration. Here a near‐infrared (NIR)‐driven ROS self‐supplying nanomotor is successfully designed for synergistic chemodynamic therapy (CDT) photothermal (PTT). Janus created by asymmetrical modification polydopamine (PDA) with zinc (ZnO 2 ) subsequent ferrous ion (Fe 2+ chelation via polyphenol groups from PDA, here refer as ZnO @PDA‐Fe (Z@P‐F). capable slowly releasing (H O into an acidic microenvironment (TME) providing ingredients Fenton reaction necessary ferroptosis. Upon NIR laser irradiation, loaded Fe released thermal gradient simultaneously formed owing asymmetric PDA coating, thus endowing self‐thermophoresis based enhanced diffusion lysosomal escape Therefore, release ions ), self‐supplied H , nanomotors actuation further improve CDT/PTT efficacy, showing great potential active therapy.

Language: Английский

Citations

17
Understanding the chemistry of mesostructured porous nanoreactors DOI
Yuzhu Ma, Haitao Li, Jian Liu

et al.

Nature Reviews Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

Citations

14
Tumour microenvironment-responded Fe-doped carbon dots-sensitized cubic Cu2O for Z-scheme heterojunction-enhanced sono-chemodynamic synergistic tumor therapy DOI

Chuanqi Feng,

Lumin Wang, Da‐Shuai Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 681 - 692

Published: March 27, 2024

Language: Английский

Citations

13
Cholesterol Depletion‐Enhanced Ferroptosis and Immunotherapy via Engineered Nanozyme DOI Creative Commons

Tingjie Bai,

P. Xue,

Sijie Shao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Ferroptosis, an iron- and reactive oxygen species (ROS)-dependent cell death, holds significant promise for tumor therapy due to its ability induce lipid peroxidation (LPO) trigger antitumor immune responses. However, elevated cholesterol levels in cancer cells impede ferroptosis compromise function. Here, a novel nanozyme, Fe-MOF/CP, composed of iron metal-organic framework (Fe-MOF) nanoparticles loaded with oxidase PEGylation integrated immunotherapy is introduced. Fe-MOF/CP depletes generates hydrogen peroxide, enhancing ROS inducing LPO, thereby promoting ferroptosis. This process disrupts raft integrity downregulates glutathione peroxidase 4 suppressor protein 1, further facilitating Concurrently, augments immunogenic reduces programmed death-ligand 1 expression, revitalizes exhausted CD8

Language: Английский

Citations

12
Sono-blasting Triggered Cascading-Amplification of Oxidative Stress for Enhanced Interventional Therapy of Hepatocellular Carcinoma DOI
Dong Li, Kexin Zhang, Kaiyang Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(29), P. 8996 - 9003

Published: July 12, 2024

Interventional therapy is widely regarded as a highly promising treatment approach for nonsurgical liver cancer. However, the development of drug resistance and tolerance to hypoxic environments after embolization can lead increased angiogenesis, enhanced tumor cell stemness, greater invasiveness, resulting in metastasis recurrence. To address these challenges, novel involving use lecithin DSPE-PEG comodified Ca

Language: Английский

Citations

7
Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity DOI Open Access
Qinyanqiu Xiang, Xue Yang, Zhi‐Qi Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade reported maximize ICD-mediated anti-tumor immunity. This LPO nanoamplifier causes explosion by Fe (II)-mediated Fenton reaction Mo(V)-mediated Russell mechanism. Subsequently, elicits ICD magnification of tumor cells inducing multiple regulated patterns ferroptosis, apoptosis, necroptosis. Additionally, antagonist (SCH58261), an immunometabolic checkpoint blocker, relieve ADO-related immunosuppression, amplify immunological effects, elicit immune memory responses. robust immunity observed primary, distant, pulmonary metastatic, recurrent tumors. study provides novel for optimizing immunotherapy highlights benefits enhance immunotherapy.

Language: Английский

Citations

1
Engineered nanoplatform mediated gas therapy enhanced ferroptosis for tumor therapy in vivo DOI Creative Commons
Kun Xu, Ke Li, Ye He

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 488 - 500

Published: Nov. 5, 2024

Language: Английский

Citations

5
Metal ions-anchored bacterial outer membrane vesicles for enhanced ferroptosis induction and immune stimulation in targeted antitumor therapy DOI Creative Commons
Ying Sun, Yanyan Ma,

Shijie Shangguan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 9, 2024

The activation of ferroptosis presents a versatile strategy for enhancing the antitumor immune responses in cancer therapy. However, developing inducers that combine high biocompatibility and therapeutic efficiency remains challenging. In this study, we propose novel approach using biological nanoparticles derived from outer membrane vesicles (OMVs) Escherichia coli tumor treatment, aiming to activate stimulate responses. Specifically, functionalize OMVs by anchoring them with ferrous ions via electrostatic interactions loading STING agonist-4, followed tumor-targeting DSPE-PEG-FA decoration, henceforth referred as OMV/SaFeFA. endows peroxidase-like activity, capable inducing cellular lipid peroxidation catalyzing H

Language: Английский

Citations

4
Interfacial templating strategy for asymmetric mesoporous materials: Synthesis and typical applications DOI Creative Commons

Sitan Li,

Junchen Zhu,

Duoxin Shi

et al.

Next Materials, Journal Year: 2024, Volume and Issue: 2, P. 100144 - 100144

Published: Jan. 1, 2024

Asymmetric mesoporous materials have attracted enormous attention due to their unique anisotropic architectures, composition and functional asymmetry, on the basis of inheriting advantages traditional (large surface area, tunable pore size, etc.). The popularity asymmetric stems from special properties derived structures. individual portions can be selectively modified function independently, achieving coordination without mutual interference, which holds great potential for use in catalysis, energy conversion storage, biomedicine, etc. Generally, inspiration synthesis comes methods, modulation interface template make architectures grow symmetric asymmetric. Therefore, types interfaces (gas-solid, liquid-solid, liquid-liquid interface) play an important role construction architectures. Through precise manipulation assembly micelles at diverse interfaces, with distinct structures been synthesized, such as dumbbell-like, tadpole-like, calabash-shape, also multi-level Nowadays, growing demands complexity application scenarios, nanomaterials novel structures, morphologies, compositions functions are urgently needed. In this review, both characteristic applications systematically summarized. We highlight synthetic strategies examples via interfacial templating approach, including selective deposition gas-solid or alteration liquid-solid interfaces. addition, specific these structure-activity relationships domains electrochemical biomedicine discussed. Finally, challenges perspectives field future outlook proposed.

Language: Английский

Citations

3